Showing 1–50 of 52 results for author: Tu, Z

Operation and performance of ProtoDUNE Dual Phase liquid argon time projection chamber

Authors: DUNE Collaboration, S. Abbaslu, F. Abd Alrahman, A. Abed Abud, R. Acciarri, L. P. Accorsi, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, K. Adhikari, C. Adriano, K. Agudelo-Jaramillo, F. Akbar, F. Alemanno, N. S. Alex, L. Aliaga Soplin, A. Alqaisi, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, R. Amarinei , et al. (1341 additional authors not shown)

Abstract: ProtoDUNE-DP was the largest ever built Liquid Argon Time Projection Chamber (LArTPC) operating in Dual-Phase (DP) mode, with a liquid target and charge read-out placed in the gas. It had an active volume of $6\times6\times6$\,m$^3$ corresponding to an active mass of 300\,t (total LAr mass of 720\,t), constructed at the CERN Neutrino Platform and took data from 2019 to 2020 with cosmic muons. In P… ▽ More ProtoDUNE-DP was the largest ever built Liquid Argon Time Projection Chamber (LArTPC) operating in Dual-Phase (DP) mode, with a liquid target and charge read-out placed in the gas. It had an active volume of $6\times6\times6$\,m$^3$ corresponding to an active mass of 300\,t (total LAr mass of 720\,t), constructed at the CERN Neutrino Platform and took data from 2019 to 2020 with cosmic muons. In ProtoDUNE-DP the electric drift field is oriented in the vertical direction, causing the electrons to drift vertically towards the anode at the top. The ionization charge is then extracted into the gaseous argon above the liquid surface, amplified by Townsend avalanches, and collected by the charge readout planes. The detector experienced significant technical problems affecting the long-term operation of the Charge Readout Planes, formed by the Large Electron Multipliers, but other critical segments demonstrated required performance including the delivery of -300 kV to the TPC cathode, verification of replaceable charge read-out electronics, and operation of the photon detection system. ProtoDUNE-DP experience resulted in improved designs of the Vertical Drift LArTPC. △ Less

Submitted 21 July, 2026; v1 submitted 17 July, 2026; originally announced July 2026.

Comments: 103 pages, 66 figures

Report number: FERMILAB-PUB-26-0466-LBNF

Geometric Bounds on the Finite-Time Performance of Active Machines

Authors: Geng Li, Z. C. Tu

Abstract: Optimizing energy conversion in active matter remains a central challenge in nonequilibrium physics. Here, we develop a unified thermodynamic framework that characterizes the finite-time performance of interacting active machines. We show that cyclic work admits a geometric decomposition into an antisymmetric thermodynamic curvature, governing work extraction, and a symmetric metric, controlling d… ▽ More Optimizing energy conversion in active matter remains a central challenge in nonequilibrium physics. Here, we develop a unified thermodynamic framework that characterizes the finite-time performance of interacting active machines. We show that cyclic work admits a geometric decomposition into an antisymmetric thermodynamic curvature, governing work extraction, and a symmetric metric, controlling dissipation. Minimal-dissipation protocols follow geodesics in parameter space, while optimal work extraction deviates from them due to a curvature-induced, Lorentz-like effect. This geometric structure directly determines the finite-time scaling of work and dissipation, enabling a mapping onto Onsager-type quasi-linear current--force relations. We show that both the maximal efficiency and the efficiency at maximum power are governed by an asymmetry parameter and a figure of merit, establishing a formal correspondence between active machines and thermoelectric devices with broken time-reversal symmetry. Our results reveal a fundamental geometric origin of energy-conversion performance and provide a general framework for optimizing active machines. △ Less

Submitted 9 June, 2026; v1 submitted 2 June, 2026; originally announced June 2026.

Charge readout electronics for the DUNE horizontal drift far detector: design and performance in ProtoDUNE-HD

Authors: DUNE Collaboration, S. Abbaslu, F. Abd Alrahman, A. Abed Abud, R. Acciarri, L. P. Accorsi, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, K. Adhikari, C. Adriano, K. Agudelo-Jaramillo, F. Akbar, F. Alemanno, N. S. Alex, L. Aliaga Soplin, A. Alqaisi, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, R. Amarinei , et al. (1346 additional authors not shown)

Abstract: DUNE (Deep Underground Neutrino Experiment) is a long-baseline neutrino oscillation experiment currently under construction, whose far detectors will be the largest liquid argon time projection chambers ever built. This detector design calls for custom-built cryogenic front-end electronics to meet its performance requirements. This paper describes the charge readout electronics that will be used i… ▽ More DUNE (Deep Underground Neutrino Experiment) is a long-baseline neutrino oscillation experiment currently under construction, whose far detectors will be the largest liquid argon time projection chambers ever built. This detector design calls for custom-built cryogenic front-end electronics to meet its performance requirements. This paper describes the charge readout electronics that will be used in the DUNE horizontal drift (HD) far detector and presents performance results using data from the ProtoDUNE-HD detector, a 770 ton liquid argon time projection chamber operated at the CERN Neutrino Platform in 2024 that served as the final prototype of the DUNE HD design. △ Less

Submitted 12 August, 2026; v1 submitted 26 April, 2026; originally announced April 2026.

Comments: Accepted version

Report number: FERMILAB-PUB-26-0270-LBNF, CERN-EP-2026-128

Journal ref: JINST 21 (2026) P08018

Macroscopic Thermodynamic Framework for the Mpemba Effect

Authors: Yun-Qian Lin, Z. C. Tu, Yu-Han Ma

Abstract: The counterintuitive Mpemba effect, wherein a hotter system cools faster, critically lacks a general macroscopic theory. Here, starting from linear irreversible thermodynamics, we formulate a generalized Newton's cooling law, $\mathrm{d}T/\mathrm{d}t = -[γ_0 + \mathcal{M}Q(t)](T-T_r)$, for a system at temperature $T$ relaxing in a thermal reservoir at $T_r$, where the bare relaxation rate $γ_0$ is… ▽ More The counterintuitive Mpemba effect, wherein a hotter system cools faster, critically lacks a general macroscopic theory. Here, starting from linear irreversible thermodynamics, we formulate a generalized Newton's cooling law, $\mathrm{d}T/\mathrm{d}t = -[γ_0 + \mathcal{M}Q(t)](T-T_r)$, for a system at temperature $T$ relaxing in a thermal reservoir at $T_r$, where the bare relaxation rate $γ_0$ is modified by an initial-state memory term, $Q(t) \propto T(0)-T_r$. Arising from the interplay between heat flux and structural evolution, the coefficient $\mathcal{M}$ governs anomalous relaxation behaviors, where $\mathcal{M} > 0$ ($\mathcal{M} < 0$) induces the (inverse) Mpemba effect. This universal thermodynamic framework maps out phase diagram to provide general criteria for the Mpemba effect in complex systems, offering a macroscopic picture that bridges disparate microscopic approaches. △ Less

Submitted 20 May, 2026; v1 submitted 20 March, 2026; originally announced March 2026.

Comments: Bringing Mpemba research back to the macroscopic world. Never forget the original inquiry, and the ultimate truth shall be reached

Synthetic Data in MR Spectroscopy: Current Practices, Applications, and Considerations

Authors: John T. LaMaster, Aaron T. Gudmundson, Alireza Abaei, Seyma Alcicek, Arturo Alvarado, Ovidiu Andronesi, Tiffany K. Bell, Wolfgang Bogner, Hanna Bugler, Alexander R Craven, Cristina Cudalbu, Alma Davidson, Christopher W. Davies-Jenkins, Dinesh Deelchand, Richard A. E. Edden, Morteza Esmaeili, Candace C Fleischer, Abdelrahman Gad, Guglielmo Genovese, Saumya Gurbani, Ashley D. Harris, Pierre-Gilles Henry, Kay Chioma Igwe, Ajin Joy, Margarida Julià-Sapé , et al. (53 additional authors not shown)

Abstract: The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data availability, particularly for clinical populations, and offers co… ▽ More The use of synthetic data has emerged as an essential tool in Magnetic Resonance Spectroscopy (MRS) research and applications, providing advantages for optimization of acquisition, software validation, deep learning applications, and enhanced reproducibility. Importantly, synthetic data addresses challenges of limited training data availability, particularly for clinical populations, and offers controlled solutions for investigating uncertainties and unexplained variance with in vivo data. This work provides a review and evaluation of current practices in the use and generation of synthetic data within the MRS field. Conducted by the MRS Synthetic Data Working Group under the Code & Data Sharing Committee of the MRS Study Group of the International Society for Magnetic Resonance in Medicine (ISMRM), this manuscript encompasses existing literature, supplemented by collective experience and in-house methodologies. △ Less

Submitted 9 March, 2026; v1 submitted 26 February, 2026; originally announced February 2026.

Comments: Word Count: 20,493; Figure Count: 6; Table Count: 0 (All tables are in the supplement)

Deterministic Control of Extreme Events in a semiconductor VCSEL via Polarization-Engineered Optical Feedback

Authors: T. Wang, Z. Li, Y. Ma, J. Huang, Y. Li, Z. Tu, S. Xiang, G. Ruocco, Y. Hao

Abstract: Extreme events, or rogue waves, are high-amplitude, rare occurrences that emerge across diverse physical systems and often defy conventional statistical predictions. While optical systems provide a controlled setting for studying these phenomena, achieving deterministic control over their generation remains challenging. Here, we demonstrate a novel approach to induce and precisely modulate extreme… ▽ More Extreme events, or rogue waves, are high-amplitude, rare occurrences that emerge across diverse physical systems and often defy conventional statistical predictions. While optical systems provide a controlled setting for studying these phenomena, achieving deterministic control over their generation remains challenging. Here, we demonstrate a novel approach to induce and precisely modulate extreme events in a semiconductor VCSEL using polarization-controlled optical feedback. By integrating a $λ$/2-waveplate into a polarization-selective external cavity, we regulate the nonlinear interaction between TE and TM modes. This setup triggers high-intensity, heavy-tailed fluctuations in the TM mode, exhibiting clear signatures of extreme events. We show that these events arise from deterministic energy exchange between modes, as evidenced by strong bipolar correlations and long-range temporal memory. The waveplate angle serves as an effective external parameter, enabling non-monotonic tuning of the event rate, intensity, and temporal clustering. Our study establish a platform for exploring extreme events in dissipative systems, with implications for nonlinear photonics and optical technologies. △ Less

Submitted 2 February, 2026; originally announced February 2026.

Photonic spiking reinforcement learning for intelligent routing

Authors: Shuiying Xiang, Yonghang Chen, Ling Zheng, Zhicong Tu, Xintao Zeng, Mengting Yu, Shuai Wang, Yahui Zhang, Xingxing Guo, Weitao Pan, Yue Hao

Abstract: Intelligent routing plays a key role in modern communication infrastructure, including data centers, computing networks, and future 6G networks. Although reinforcement learning (RL) has shown great potential for intelligent routing, its practical deployment remains constrained by high energy consumption and decision latency. Here, we propose a photonic spiking RL architecture that implements a pro… ▽ More Intelligent routing plays a key role in modern communication infrastructure, including data centers, computing networks, and future 6G networks. Although reinforcement learning (RL) has shown great potential for intelligent routing, its practical deployment remains constrained by high energy consumption and decision latency. Here, we propose a photonic spiking RL architecture that implements a proximal policy optimization (PPO)-based intelligent routing algorithm. The performance of the proposed approach is systematically evaluated on a software-defined network (SDN) with a fat-tree topology. The results demonstrate that, under various baseline traffic rate conditions, the PPO-based routing strategy significantly outperforms the conventional Dijkstra algorithm in several key performance metrics. Furthermore, a hardware-software collaborative framework of the spiking Actor network is realized for three typical baseline traffic rates, utilizing a photonic synapse chip based on a Mach-Zehnder interferometer (MZI) array and a photonic spiking neuron chip based on distributed feedback lasers with a saturable absorber (DFB-SAs). Experimental validation on 640 state-action pairs shows that the inference accuracy of the hardware-software collaborative framework is consistent with that of the pure algorithmic implementation. The impacts of different hidden-layer scales in the spiking Actor network and varying network size of fat-tree topology are further analyzed. The integration of photonic spiking RL with SDN-based routing establishes a novel paradigm for intelligent routing optimization, featuring ultra-low latency and high energy efficiency. This approach exhibits broad application prospects in real-time network optimization scenarios, including large-scale data centers, computing networks, satellite Internet systems, and future 6G networks. △ Less

Submitted 1 February, 2026; originally announced February 2026.

Comments: 22 pages, 7 figures, submitted to Opto-Electronic Science (under review)

Recursive Inverse Design Enables Hyper-spectral Photonic Integrated Circuits

Authors: Hao He, Zengji Tu, Yuanlei Wang, Hongyan Zhao, Chuangxin Feng, Yongzhuo Zhou, Yujun Chen, Ruoao Yang, Lei Zhang, Jianjun Wu, Qi-Fan Yang, Lin Chang

Abstract: Spectrum manipulation is central to photonic systems, where advanced computing and sensing applications often demand highly complex spectral responses to achieve high throughput. Conventional methods for enhancing spectral complexity typically rely on cascading discrete photonic components, resulting in a complexity that scales only linearly with the number of components. Here, we introduce hyper-… ▽ More Spectrum manipulation is central to photonic systems, where advanced computing and sensing applications often demand highly complex spectral responses to achieve high throughput. Conventional methods for enhancing spectral complexity typically rely on cascading discrete photonic components, resulting in a complexity that scales only linearly with the number of components. Here, we introduce hyper-spectral photonic integrated circuits (HS-PICs), in which spectral complexity scales exponentially with the number of components. This is achieved through recursive inverse design - a system-level inverse design strategy that exploits intricate inter-component interactions as design freedoms, thereby substantially expanding the design space for spectral engineering. Using this approach, we demonstrate that even a single waveguide structure can resolve spectra with sub-picometer resolution, surpassing the performance of current state-of-the-art spectrometers. This performance bridges optical and microwave frequencies in spectral analysis, enabling simultaneous monitoring of optical and radio signals within a single device. Our work establishes a transformative framework for next-generation computing and sensing technologies. △ Less

Submitted 13 October, 2025; originally announced October 2025.

Comments: 12 pages, 4 figures

Nonreciprocal optical circuit switching

Authors: Zhifeng Tu, Yucong Yang, Yiran Wei, Shuyuan Liu, Fangchen Hu, Peng Zou, Chengkun Yang, Tianchi Zhang, Di Wu, Ruoyu Shen, Bingzhou Hong, Haiwen Cai, Lei Bi, Wei Chu

Abstract: Directly switching optical signals outperforms conventional optoelectronic hardware in terms of cost, latency, and energy efficiency, and is expected to address the growing demand for data node capacity driven by the development of machine learning and artificial intelligence (AI) technologies. Therefore, optical circuit switching (OCS) technology has piqued widespread research interest in various… ▽ More Directly switching optical signals outperforms conventional optoelectronic hardware in terms of cost, latency, and energy efficiency, and is expected to address the growing demand for data node capacity driven by the development of machine learning and artificial intelligence (AI) technologies. Therefore, optical circuit switching (OCS) technology has piqued widespread research interest in various technical solutions, including silicon photonics. However, silicon-based integrated OCS remains constrained by challenges such as network performance and port scalability. Here we propose a magneto-optical heterogeneous integrated nonreciprocal OCS (NOCS) network based on a silicon photonics platform, achieving bidirectional full-duplex nonreciprocal transmission by programming reciprocal and nonreciprocal phase shifters. We demonstrate that compared with the existing OCS architecture, NOCS has the advantages of ultra-high reconfiguration speed, large-scale integration compatibility, and bidirectional channel isolation reducing the number of required ports. NOCS could meet the programming speed requirements of the AI backend network, or supports nonreciprocal optical switching applications without multiplexing technology. △ Less

Submitted 24 September, 2025; originally announced September 2025.

Comments: 24 pages, 5 figures

Operation of a Modular 3D-Pixelated Liquid Argon Time-Projection Chamber in a Neutrino Beam

Authors: DUNE Collaboration, S. Abbaslu, A. Abed Abud, R. Acciarri, L. P. Accorsi, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, C. Adriano, F. Akbar, F. Alemanno, N. S. Alex, K. Allison, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, P. Amedo, J. Anderson, D. A. Andrade, C. Andreopoulos, M. Andreotti , et al. (1299 additional authors not shown)

Abstract: The 2x2 Demonstrator, a prototype for the Deep Underground Neutrino Experiment (DUNE) liquid argon (LAr) Near Detector, was exposed to the Neutrinos from the Main Injector (NuMI) neutrino beam at Fermi National Accelerator Laboratory (Fermilab). This detector prototypes a new modular design for a liquid argon time-projection chamber (LArTPC), comprised of a two-by-two array of four modules, each f… ▽ More The 2x2 Demonstrator, a prototype for the Deep Underground Neutrino Experiment (DUNE) liquid argon (LAr) Near Detector, was exposed to the Neutrinos from the Main Injector (NuMI) neutrino beam at Fermi National Accelerator Laboratory (Fermilab). This detector prototypes a new modular design for a liquid argon time-projection chamber (LArTPC), comprised of a two-by-two array of four modules, each further segmented into two optically-isolated LArTPCs. The 2x2 Demonstrator features a number of pioneering technologies, including a low-profile resistive field shell to establish drift fields, native 3D ionization pixelated imaging, and a high-coverage dielectric light readout system. The 2.4 tonne active mass detector is flanked upstream and downstream by supplemental solid-scintillator tracking planes, repurposed from the MINERvA experiment, which track ionizing particles exiting the argon volume. The antineutrino beam data collected by the detector over a 4.5 day period in 2024 include over 30,000 neutrino interactions in the LAr active volume-the first neutrino interactions reported by a DUNE detector prototype. During its physics-quality run, the 2x2 Demonstrator operated at a nominal drift field of 500 V/cm and maintained good LAr purity, with a stable electron lifetime of approximately 1.25 ms. This paper describes the detector and supporting systems, summarizes the installation and commissioning, and presents the initial validation of collected NuMI beam and off-beam self-triggers. In addition, it highlights observed interactions in the detector volume, including candidate muon anti-neutrino events. △ Less

Submitted 17 June, 2026; v1 submitted 6 September, 2025; originally announced September 2025.

Report number: FERMILAB-PUB-25-0537-LBNF

Journal ref: Instruments 2026, 10(1), 18

A minimal model with stochastically broken reciprocity

Authors: Z. C. Tu

Abstract: We introduce a minimal model consisting of a two-body system with stochastically broken reciprocity (i.e., random violation of Newton's third law) and then investigate its statistical behaviors, including fluctuations of velocity and position, time evolution of probability distribution functions, energy gain, and entropy production. The effective temperature of this two-body system immersed in a t… ▽ More We introduce a minimal model consisting of a two-body system with stochastically broken reciprocity (i.e., random violation of Newton's third law) and then investigate its statistical behaviors, including fluctuations of velocity and position, time evolution of probability distribution functions, energy gain, and entropy production. The effective temperature of this two-body system immersed in a thermal bath is also derived. Furthermore, we heuristically present an extremely minimal model where the relative motion adheres to the same rules as in classical mechanics, while the effect of stochastically broken reciprocity only manifests in the fluctuating motion of the center of mass. △ Less

Submitted 19 August, 2025; v1 submitted 20 July, 2025; originally announced July 2025.

Comments: 9 pages, 2 figure, submitted to communications in theoretical physics

Journal ref: Commun. Theor. Phys. 78 025601 (2026)

Spatial and Temporal Evaluations of the Liquid Argon Purity in ProtoDUNE-SP

Authors: DUNE Collaboration, S. Abbaslu, A. Abed Abud, R. Acciarri, L. P. Accorsi, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, C. Adriano, F. Akbar, F. Alemanno, N. S. Alex, K. Allison, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, P. Amedo, J. Anderson, D. A. Andrade, C. Andreopoulos, M. Andreotti , et al. (1301 additional authors not shown)

Abstract: Liquid argon time projection chambers (LArTPCs) rely on highly pure argon to ensure that ionization electrons produced by charged particles reach readout arrays. ProtoDUNE Single-Phase (ProtoDUNE-SP) was an approximately 700-ton liquid argon detector intended to prototype the Deep Underground Neutrino Experiment (DUNE) Far Detector Horizontal Drift module. It contains two drift volumes bisected by… ▽ More Liquid argon time projection chambers (LArTPCs) rely on highly pure argon to ensure that ionization electrons produced by charged particles reach readout arrays. ProtoDUNE Single-Phase (ProtoDUNE-SP) was an approximately 700-ton liquid argon detector intended to prototype the Deep Underground Neutrino Experiment (DUNE) Far Detector Horizontal Drift module. It contains two drift volumes bisected by the cathode plane assembly, which is biased to create an almost uniform electric field in both volumes. The DUNE Far Detector modules must have robust cryogenic systems capable of filtering argon and supplying the TPC with clean liquid. This paper will explore comparisons of the argon purity measured by the purity monitors with those measured using muons in the TPC from October 2018 to November 2018. A new method is introduced to measure the liquid argon purity in the TPC using muons crossing both drift volumes of ProtoDUNE-SP. For extended periods on the timescale of weeks, the drift electron lifetime was measured to be above 30 ms using both systems. A particular focus will be placed on the measured purity of argon as a function of position in the detector. △ Less

Submitted 27 August, 2025; v1 submitted 11 July, 2025; originally announced July 2025.

Report number: CERN-EP-2025-157, FERMILAB-PUB-25-0445-V

Journal ref: JINST (2025) 20 P09008

Mode locking via delayed orthogonal-polarization reinjection in semiconductor VCSELs

Authors: T. Wang, Y. Ma, Z. Li, Y. Li, Z. Tu, Y. Zhang, G. Xu, S. Baland, S. Xiang, Y. Hao

Abstract: We demonstrate harmonic mode-locking in a semiconductor VCSEL using polarization-controlled delayed feedback. By integrating a rotatable $λ$/2-plate within an external cavity, we achieve precise control over pulse multiplicity and repetition rates in TE and TM modes. For the TE mode, increasing the $λ$/2-plate angle ($θ$) transitions the system from disordered quasi-periodic states to stable funda… ▽ More We demonstrate harmonic mode-locking in a semiconductor VCSEL using polarization-controlled delayed feedback. By integrating a rotatable $λ$/2-plate within an external cavity, we achieve precise control over pulse multiplicity and repetition rates in TE and TM modes. For the TE mode, increasing the $λ$/2-plate angle ($θ$) transitions the system from disordered quasi-periodic states to stable fundamental (single-pulse) and harmonic dual-pulse mode-locking. Polarization-resolved measurements and cross-correlation analyses reveal coherent pulse alignment at half the cavity roundtrip time, enabled by polarization-mediated nonlinear dynamics. This work establishes cross-polarization feedback as a fundamental mechanism for ultrafast pulse engineering, advancing the understanding of polarization-mediated nonlinear dynamics in laser physics. △ Less

Submitted 17 June, 2025; v1 submitted 16 April, 2025; originally announced April 2025.

European Contributions to Fermilab Accelerator Upgrades and Facilities for the DUNE Experiment

Authors: DUNE Collaboration, A. Abed Abud, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, F. Alemanno, N. S. Alex, K. Allison, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, P. Amedo, J. Anderson, D. A. Andrade , et al. (1322 additional authors not shown)

Abstract: The Proton Improvement Plan (PIP-II) to the FNAL accelerator chain and the Long-Baseline Neutrino Facility (LBNF) will provide the world's most intense neutrino beam to the Deep Underground Neutrino Experiment (DUNE) enabling a wide-ranging physics program. This document outlines the significant contributions made by European national laboratories and institutes towards realizing the first phase o… ▽ More The Proton Improvement Plan (PIP-II) to the FNAL accelerator chain and the Long-Baseline Neutrino Facility (LBNF) will provide the world's most intense neutrino beam to the Deep Underground Neutrino Experiment (DUNE) enabling a wide-ranging physics program. This document outlines the significant contributions made by European national laboratories and institutes towards realizing the first phase of the project with a 1.2 MW neutrino beam. Construction of this first phase is well underway. For DUNE Phase II, this will be closely followed by an upgrade of the beam power to > 2 MW, for which the European groups again have a key role and which will require the continued support of the European community for machine aspects of neutrino physics. Beyond the neutrino beam aspects, LBNF is also responsible for providing unique infrastructure to install and operate the DUNE neutrino detectors at FNAL and at the Sanford Underground Research Facility (SURF). The cryostats for the first two Liquid Argon Time Projection Chamber detector modules at SURF, a contribution of CERN to LBNF, are central to the success of the ongoing execution of DUNE Phase I. Likewise, successful and timely procurement of cryostats for two additional detector modules at SURF will be critical to the success of DUNE Phase II and the overall physics program. The DUNE Collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This paper is being submitted to the 'Accelerator technologies' and 'Projects and Large Experiments' streams. Additional inputs related to the DUNE science program, DUNE detector technologies and R&D, and DUNE software and computing, are also being submitted to other streams. △ Less

Submitted 31 March, 2025; originally announced March 2025.

Comments: Submitted to the 2026 Update of the European Strategy for Particle Physics

DUNE Software and Computing Research and Development

Authors: DUNE Collaboration, A. Abed Abud, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, F. Alemanno, N. S. Alex, K. Allison, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, P. Amedo, J. Anderson, D. A. Andrade , et al. (1322 additional authors not shown)

Abstract: The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The ambitious physics program of Phase I and Phase II of DUNE is dependent upon deployment and utilization of significant computing res… ▽ More The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The ambitious physics program of Phase I and Phase II of DUNE is dependent upon deployment and utilization of significant computing resources, and successful research and development of software (both infrastructure and algorithmic) in order to achieve these scientific goals. This submission discusses the computing resources projections, infrastructure support, and software development needed for DUNE during the coming decades as an input to the European Strategy for Particle Physics Update for 2026. The DUNE collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This submission to the 'Computing' stream focuses on DUNE software and computing. Additional inputs related to the DUNE science program, DUNE detector technologies and R&D, and European contributions to Fermilab accelerator upgrades and facilities for the DUNE experiment, are also being submitted to other streams. △ Less

Submitted 31 March, 2025; originally announced March 2025.

Comments: Submitted to the 2026 Update of the European Strategy for Particle Physics

The DUNE Phase II Detectors

Authors: DUNE Collaboration, A. Abed Abud, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, F. Alemanno, N. S. Alex, K. Allison, M. Alrashed, A. Alton, R. Alvarez, T. Alves, A. Aman, H. Amar, P. Amedo, J. Anderson, D. A. Andrade , et al. (1322 additional authors not shown)

Abstract: The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy for the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and… ▽ More The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy for the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the previous European Strategy for Particle Physics. The construction of DUNE Phase I is well underway. DUNE Phase II consists of a third and fourth far detector module, an upgraded near detector complex, and an enhanced > 2 MW beam. The fourth FD module is conceived as a 'Module of Opportunity', aimed at supporting the core DUNE science program while also expanding the physics opportunities with more advanced technologies. The DUNE collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This submission to the 'Detector instrumentation' stream focuses on technologies and R&D for the DUNE Phase II detectors. Additional inputs related to the DUNE science program, DUNE software and computing, and European contributions to Fermilab accelerator upgrades and facilities for the DUNE experiment, are also being submitted to other streams. △ Less

Submitted 29 March, 2025; originally announced March 2025.

Comments: Submitted to the 2026 Update of the European Strategy for Particle Physics

An artificially intelligent magnetic resonance spectroscopy quantification method: Comparison between QNet and LCModel on the cloud computing platform CloudBrain-MRS

Authors: Meijin Lin, Lin Guo, Dicheng Chen, Jianshu Chen, Zhangren Tu, Xu Huang, Jianhua Wang, Ji Qi, Yuan Long, Zhiguo Huang, Di Guo, Xiaobo Qu, Haiwei Han

Abstract: Objctives: This work aimed to statistically compare the metabolite quantification of human brain magnetic resonance spectroscopy (MRS) between the deep learning method QNet and the classical method LCModel through an easy-to-use intelligent cloud computing platform CloudBrain-MRS. Materials and Methods: In this retrospective study, two 3 T MRI scanners Philips Ingenia and Achieva collected 61 and… ▽ More Objctives: This work aimed to statistically compare the metabolite quantification of human brain magnetic resonance spectroscopy (MRS) between the deep learning method QNet and the classical method LCModel through an easy-to-use intelligent cloud computing platform CloudBrain-MRS. Materials and Methods: In this retrospective study, two 3 T MRI scanners Philips Ingenia and Achieva collected 61 and 46 in vivo 1H magnetic resonance (MR) spectra of healthy participants, respectively, from the brain region of pregenual anterior cingulate cortex from September to October 2021. The analyses of Bland-Altman, Pearson correlation and reasonability were performed to assess the degree of agreement, linear correlation and reasonability between the two quantification methods. Results: Fifteen healthy volunteers (12 females and 3 males, age range: 21-35 years, mean age/standard deviation = 27.4/3.9 years) were recruited. The analyses of Bland-Altman, Pearson correlation and reasonability showed high to good consistency and very strong to moderate correlation between the two methods for quantification of total N-acetylaspartate (tNAA), total choline (tCho), and inositol (Ins) (relative half interval of limits of agreement = 3.04%, 9.3%, and 18.5%, respectively; Pearson correlation coefficient r = 0.775, 0.927, and 0.469, respectively). In addition, quantification results of QNet are more likely to be closer to the previous reported average values than those of LCModel. Conclusion: There were high or good degrees of consistency between the quantification results of QNet and LCModel for tNAA, tCho, and Ins, and QNet generally has more reasonable quantification than LCModel. △ Less

Submitted 6 March, 2025; originally announced March 2025.

Tagging Efficiency Study of Incoherent Diffractive Vector Meson Production at the Second Interaction Region at the Electron-Ion Collider

Authors: Elke-Caroline Aschenauer, Alexander Bazilevsky, Alexander Jentsch, Jihee Kim, Alexander Kiselev, Brian Page, Zhoudunming Tu, Thomas Ullrich, Cheuk-Ping Wong

Abstract: The Electron-Ion Collider (EIC) is an upcoming accelerator facility aimed at exploring the properties of quarks and gluons in nucleons and nuclei, shedding light on their structure and dynamics. The inaugural experimental apparatus, ePIC (electron-Proton and Ion Collider), is designed as a general purpose detector to address the NAS/NSAC physics program at the EIC. The wider EIC community is stron… ▽ More The Electron-Ion Collider (EIC) is an upcoming accelerator facility aimed at exploring the properties of quarks and gluons in nucleons and nuclei, shedding light on their structure and dynamics. The inaugural experimental apparatus, ePIC (electron-Proton and Ion Collider), is designed as a general purpose detector to address the NAS/NSAC physics program at the EIC. The wider EIC community is strongly supporting a second interaction region and associated second detector to enhance the full science program. In this study, we evaluate how the second interaction region and detector can be complementary to ePIC. The pre-conceptual layout of an interaction region for the second detector offers a secondary focus that provides better forward detector acceptance at scattering angles near $θ\sim 0$~mrad, which can specifically enhance the exclusive, tagging, and diffractive physics program. This article presents an analysis of a tagging program using the second interaction region layout with incoherent diffractive vector meson production. The potential for the second interaction region to provide improved vetoing capabilities for incoherent events to elucidate the coherent diffractive cross-section is evaluated. The capability to access the coherent diffractive cross-section is of prime importance for studying the spatial imaging of nucleons and nuclei. △ Less

Submitted 17 January, 2025; originally announced January 2025.

Comments: 9 pages, 6 figures, 4 tables

Journal ref: Phys. Rev. D 111, 072013 (2025)

Fast square-oscillations in semiconductor VCSELs with delayed orthogonal polarization feedback

Authors: Tao Wang, Zhicong Tu, Yixing Ma, Yiheng Li, Zhibo Li, Fan Qin, Stephané Barland, Shuiying Xiang

Abstract: We present an experimental investigation into the generation of self-sustained and fast square oscillations from the TE mode of semiconductor VCSELs with delayed orthogonal polarization feedback. We find that the low frequency switching originates from the rotation of the TE and TM modes facilitated by a long time delay, but the fast oscillations are anchored to the frequency beating between the T… ▽ More We present an experimental investigation into the generation of self-sustained and fast square oscillations from the TE mode of semiconductor VCSELs with delayed orthogonal polarization feedback. We find that the low frequency switching originates from the rotation of the TE and TM modes facilitated by a long time delay, but the fast oscillations are anchored to the frequency beating between the TE and TM modes and are modified by a half-wavelength ($λ/2$) plate. A comprehensive analysis of the evolution of the nonlinear dynamics is conducted and the related mechanism is discussed. Our study not only deepens our comprehension of laser nonlinear dynamics but also offers an all-optical approach for producing specialized signals, which could be instrumental in applications such as optical communications and photonic computing leveraging the complexity of long-delay systems. △ Less

Submitted 18 March, 2025; v1 submitted 12 December, 2024; originally announced December 2024.

The track-length extension fitting algorithm for energy measurement of interacting particles in liquid argon TPCs and its performance with ProtoDUNE-SP data

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, N. S. Alex, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, C. Andreopoulos , et al. (1348 additional authors not shown)

Abstract: This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy los… ▽ More This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy loss as a function of the energy, including models of electron recombination and detector response. The algorithm can be used to measure the energies of particles that interact before they stop, such as charged pions that are absorbed by argon nuclei. The algorithm's energy measurement resolutions and fractional biases are presented as functions of particle kinetic energy and number of track hits using samples of stopping secondary charged pions in data collected by the ProtoDUNE-SP detector, and also in a detailed simulation. Additional studies describe the impact of the dE/dx model on energy measurement performance. The method described in this paper to characterize the energy measurement performance can be repeated in any LArTPC experiment using stopping secondary charged pions. △ Less

Submitted 26 December, 2024; v1 submitted 26 September, 2024; originally announced September 2024.

Report number: FERMILAB-PUB-24-0561-LBNF-PPD, CERN-EP-2024-256

DUNE Phase II: Scientific Opportunities, Detector Concepts, Technological Solutions

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, C. Andreopoulos, M. Andreotti , et al. (1347 additional authors not shown)

Abstract: The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I… ▽ More The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the European Strategy for Particle Physics. While the construction of the DUNE Phase I is well underway, this White Paper focuses on DUNE Phase II planning. DUNE Phase-II consists of a third and fourth far detector (FD) module, an upgraded near detector complex, and an enhanced 2.1 MW beam. The fourth FD module is conceived as a "Module of Opportunity", aimed at expanding the physics opportunities, in addition to supporting the core DUNE science program, with more advanced technologies. This document highlights the increased science opportunities offered by the DUNE Phase II near and far detectors, including long-baseline neutrino oscillation physics, neutrino astrophysics, and physics beyond the standard model. It describes the DUNE Phase II near and far detector technologies and detector design concepts that are currently under consideration. A summary of key R&D goals and prototyping phases needed to realize the Phase II detector technical designs is also provided. DUNE's Phase II detectors, along with the increased beam power, will complete the full scope of DUNE, enabling a multi-decadal program of groundbreaking science with neutrinos. △ Less

Submitted 22 August, 2024; originally announced August 2024.

Report number: FERMILAB-TM-2833-LBNF

First Measurement of the Total Inelastic Cross-Section of Positively-Charged Kaons on Argon at Energies Between 5.0 and 7.5 GeV

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, C. Andreopoulos, M. Andreotti , et al. (1341 additional authors not shown)

Abstract: ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each… ▽ More ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each beam momentum setting was measured to be 380$\pm$26 mbarns for the 6 GeV/$c$ setting and 379$\pm$35 mbarns for the 7 GeV/$c$ setting. △ Less

Submitted 1 August, 2024; originally announced August 2024.

Report number: CERN-EP-2024-211, FERMILAB-PUB-24-0216-V

Journal ref: Phys. Rev. D 110, (2024) 092011

Supernova Pointing Capabilities of DUNE

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, D. A. Andrade , et al. (1340 additional authors not shown)

Abstract: The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electr… ▽ More The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electron-neutrino charged-current absorption on 40Ar and elastic scattering of neutrinos on electrons. Procedures to reconstruct individual interactions, including a newly developed technique called ``brems flipping'', as well as the burst direction from an ensemble of interactions are described. Performance of the burst direction reconstruction is evaluated for supernovae happening at a distance of 10 kpc for a specific supernova burst flux model. The pointing resolution is found to be 3.4 degrees at 68% coverage for a perfect interaction-channel classification and a fiducial mass of 40 kton, and 6.6 degrees for a 10 kton fiducial mass respectively. Assuming a 4% rate of charged-current interactions being misidentified as elastic scattering, DUNE's burst pointing resolution is found to be 4.3 degrees (8.7 degrees) at 68% coverage. △ Less

Submitted 24 December, 2025; v1 submitted 14 July, 2024; originally announced July 2024.

Comments: 26 pages, 17 figures

Report number: FERMILAB-PUB-24-0319-LBNF

Journal ref: Phys. Rev. D 111, 092006 (Published 12 May, 2025)

Performance of a modular ton-scale pixel-readout liquid argon time projection chamber

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, D. A. Andrade , et al. (1340 additional authors not shown)

Abstract: The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmi… ▽ More The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements, and provide comparisons to detector simulations. △ Less

Submitted 5 March, 2024; originally announced March 2024.

Comments: 47 pages, 41 figures

Report number: FERMILAB-PUB-24-0073-LBNF

Doping Liquid Argon with Xenon in ProtoDUNE Single-Phase: Effects on Scintillation Light

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, H. Amar Es-sghir, P. Amedo, J. Anderson, D. A. Andrade, C. Andreopoulos , et al. (1297 additional authors not shown)

Abstract: Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUN… ▽ More Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 720 t of total liquid argon mass with 410 t of fiducial mass. A 5.4 ppm nitrogen contamination was present during the xenon doping campaign. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of non-uniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen. △ Less

Submitted 2 August, 2024; v1 submitted 2 February, 2024; originally announced February 2024.

Comments: 36 pages, 20 figures. Corrected author list; corrected typos across paper and polished text

Report number: CERN-EP-2024-024; FERMILAB-PUB-23-0819-LBNF

Journal ref: JINST 19 P08005 (2024)

The DUNE Far Detector Vertical Drift Technology, Technical Design Report

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, H. Amar, P. Amedo, J. Anderson, D. A. Andrade, C. Andreopoulos , et al. (1304 additional authors not shown)

Abstract: DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precisi… ▽ More DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals. △ Less

Submitted 5 December, 2023; originally announced December 2023.

Comments: 425 pages; 281 figures Central editing team: A. Heavey, S. Kettell, A. Marchionni, S. Palestini, S. Rajogopalan, R. J. Wilson

Report number: Fermilab Report no: TM-2813-LBNF

Engineering Ratchet-Based Particle Separation via Shortcuts to Isothermality

Authors: Xiu-Hua Zhao, Z. C. Tu, Yu-Han Ma

Abstract: Microscopic particle separation plays vital role in various scientific and industrial domains. In this Letter, we propose a universal non-equilibrium thermodynamic approach, employing the concept of Shortcuts to Isothermality, to realize controllable separation of overdamped Brownian particles. By utilizing a designed ratchet potential with temporal period $τ$, we find in the slow-driving regime t… ▽ More Microscopic particle separation plays vital role in various scientific and industrial domains. In this Letter, we propose a universal non-equilibrium thermodynamic approach, employing the concept of Shortcuts to Isothermality, to realize controllable separation of overdamped Brownian particles. By utilizing a designed ratchet potential with temporal period $τ$, we find in the slow-driving regime that the average particle velocity $\Bar{v}_s\propto\left(1-D/D^*\right)τ^{-1}$, indicating that particles with different diffusion coefficients $D$ can be guided to move in distinct directions with a preset $D^*$. Furthermore, we reveal that there exists an extra energetic cost with a lower bound $W_{\rm{ex}}^{(\rm{min})}\propto\mathcal{L}^{2}\Bar{v}_s$, alongside a quasi-static work consumption. Here, $\mathcal{L}$ is the thermodynamic length of the driving loop in the parametric space. We numerically validate our theoretical findings and illustrate the optimal separation protocol (associated with $W_{\rm{ex}}^{(\rm{min})}$) with a sawtooth potential. This study establishes a bridge between thermodynamic process engineering and particle separation, paving the way for further explorations of thermodynamic constrains and optimal control in ratchet-based particle separation. △ Less

Submitted 28 November, 2023; originally announced November 2023.

Comments: 5 pages, 3 figures + Supplemental Materials (10 pages, 4 figures). Comments are welcome!

Journal ref: Physical Review E 110, 034105 (2024)

Brownian motion of a particle with higher-derivative dynamics

Authors: Z. C. Tu

Abstract: The Brownian motion of a particle with higher-derivative dynamics (HDD) coupling with a bath consisting of harmonic oscillators is investigated. The Langevin equation and corresponding Fokker-Planck equation for the Brownian motion of the HDD particle are derived. As a case study, we particularly consider a stochastic Pais-Uhlenbeck oscillator. It is found that the Boltzmann distribution is pathol… ▽ More The Brownian motion of a particle with higher-derivative dynamics (HDD) coupling with a bath consisting of harmonic oscillators is investigated. The Langevin equation and corresponding Fokker-Planck equation for the Brownian motion of the HDD particle are derived. As a case study, we particularly consider a stochastic Pais-Uhlenbeck oscillator. It is found that the Boltzmann distribution is pathological while this distribution is the steady solution to the Fokker-Planck equation. △ Less

Submitted 10 November, 2023; v1 submitted 27 March, 2023; originally announced March 2023.

Comments: This manuscript is a translation of a Chinese paper contributing for 100 anniversary of Department of Physics, Beijing Normal University

Molecular chaos in dense active systems

Authors: Lu Chen, Kyle J. Welch, Premkumar Leishangthem, Dipanjan Ghosh, Bokai Zhang, Ting-Pi Sun, Josh Klukas, Zhanchun Tu, Xiang Cheng, Xinliang Xu

Abstract: The hypothesis of molecular chaos plays the central role in kinetic theory, which provides a closure leading to the Boltzmann equation for quantitative description of classic fluids. Yet how to properly extend it to active systems is still an open question in nonequilibrium physics. Combining experiment, simulation, and theory, we investigate the emergent collective behaviors of self-propelled par… ▽ More The hypothesis of molecular chaos plays the central role in kinetic theory, which provides a closure leading to the Boltzmann equation for quantitative description of classic fluids. Yet how to properly extend it to active systems is still an open question in nonequilibrium physics. Combining experiment, simulation, and theory, we investigate the emergent collective behaviors of self-propelled particles that exhibit collision avoidance, a moving strategy commonly adopted in natural and engineering active systems. This dense active system shows unusual phase dynamics strongly regulated by many-body interactions, which cannot be explained by theories assuming molecular chaos. To rationalize the interplay between different emergent phases, a simple kinetic model is proposed with a revised molecular chaos hypothesis, which treats the many-body effect implicitly via categorizing different types of particle pair collisions. Our model predicts an optimal growth rate of flocking and illustrates a generic approach for understanding dense active systems. △ Less

Submitted 21 February, 2023; originally announced February 2023.

Comments: 8 pages, 6 figures

Highly-parallelized simulation of a pixelated LArTPC on a GPU

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, C. Alt, A. Alton, R. Alvarez, P. Amedo, J. Anderson , et al. (1282 additional authors not shown)

Abstract: The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we pr… ▽ More The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on $10^3$ pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype. △ Less

Submitted 28 February, 2023; v1 submitted 19 December, 2022; originally announced December 2022.

Comments: 26 pages, 15 figures

Report number: FERMILAB-PUB-22-926-LBNF

Journal ref: JINST 2023 18 P04034

ATHENA Detector Proposal -- A Totally Hermetic Electron Nucleus Apparatus proposed for IP6 at the Electron-Ion Collider

Authors: ATHENA Collaboration, J. Adam, L. Adamczyk, N. Agrawal, C. Aidala, W. Akers, M. Alekseev, M. M. Allen, F. Ameli, A. Angerami, P. Antonioli, N. J. Apadula, A. Aprahamian, W. Armstrong, M. Arratia, J. R. Arrington, A. Asaturyan, E. C. Aschenauer, K. Augsten, S. Aune, K. Bailey, C. Baldanza, M. Bansal, F. Barbosa, L. Barion , et al. (415 additional authors not shown)

Abstract: ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its e… ▽ More ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges. △ Less

Submitted 13 October, 2022; originally announced October 2022.

Journal ref: JINST 17 (2022) 10, P10019

FusionRetro: Molecule Representation Fusion via In-Context Learning for Retrosynthetic Planning

Authors: Songtao Liu, Zhengkai Tu, Minkai Xu, Zuobai Zhang, Lu Lin, Rex Ying, Jian Tang, Peilin Zhao, Dinghao Wu

Abstract: Retrosynthetic planning aims to devise a complete multi-step synthetic route from starting materials to a target molecule. Current strategies use a decoupled approach of single-step retrosynthesis models and search algorithms, taking only the product as the input to predict the reactants for each planning step and ignoring valuable context information along the synthetic route. In this work, we pr… ▽ More Retrosynthetic planning aims to devise a complete multi-step synthetic route from starting materials to a target molecule. Current strategies use a decoupled approach of single-step retrosynthesis models and search algorithms, taking only the product as the input to predict the reactants for each planning step and ignoring valuable context information along the synthetic route. In this work, we propose a novel framework that utilizes context information for improved retrosynthetic planning. We view synthetic routes as reaction graphs and propose to incorporate context through three principled steps: encode molecules into embeddings, aggregate information over routes, and readout to predict reactants. Our approach is the first attempt to utilize in-context learning for retrosynthesis prediction in retrosynthetic planning. The entire framework can be efficiently optimized in an end-to-end fashion and produce more practical and accurate predictions. Comprehensive experiments demonstrate that by fusing in the context information over routes, our model significantly improves the performance of retrosynthetic planning over baselines that are not context-aware, especially for long synthetic routes. Code is available at https://github.com/SongtaoLiu0823/FusionRetro. △ Less

Submitted 31 May, 2023; v1 submitted 30 September, 2022; originally announced September 2022.

Comments: Accepted by ICML 2023

Reconstruction of interactions in the ProtoDUNE-SP detector with Pandora

Authors: DUNE Collaboration, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Aimard, F. Akbar, B. Ali-Mohammadzadeh, K. Allison, S. Alonso Monsalve, M. AlRashed, C. Alt, A. Alton, R. Alvarez, P. Amedo , et al. (1203 additional authors not shown)

Abstract: The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle interactions in liquid argon time projection chamber detectors. Pandora is the primary event reconstruction software used at ProtoDUNE-SP, a prototype for the Deep Underground Neutrino Experiment far detector. ProtoDUNE-SP, located at CERN, is exposed to a char… ▽ More The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle interactions in liquid argon time projection chamber detectors. Pandora is the primary event reconstruction software used at ProtoDUNE-SP, a prototype for the Deep Underground Neutrino Experiment far detector. ProtoDUNE-SP, located at CERN, is exposed to a charged-particle test beam. This paper gives an overview of the Pandora reconstruction algorithms and how they have been tailored for use at ProtoDUNE-SP. In complex events with numerous cosmic-ray and beam background particles, the simulated reconstruction and identification efficiency for triggered test-beam particles is above 80% for the majority of particle type and beam momentum combinations. Specifically, simulated 1 GeV/$c$ charged pions and protons are correctly reconstructed and identified with efficiencies of 86.1$\pm0.6$% and 84.1$\pm0.6$%, respectively. The efficiencies measured for test-beam data are shown to be within 5% of those predicted by the simulation. △ Less

Submitted 17 July, 2023; v1 submitted 29 June, 2022; originally announced June 2022.

Comments: 39 pages, 20 figures. Accepted version. Published version available in Eur. Phys. J. C 83, 618 (2023) https://doi.org/10.1140/epjc/s10052-023-11733-2

Report number: FERMILAB-PUB-22-488-AD-ESH-LBNF-ND-SCD, CERN-EP-DRAFT-MISC-2022-007

Journal ref: Eur. Phys. J. C 83, 618 (2023)

BeAGLE: Benchmark $e$A Generator for LEptoproduction in high energy lepton-nucleus collisions

Authors: Wan Chang, Elke-Caroline Aschenauer, Mark D. Baker, Alexander Jentsch, Jeong-Hun Lee, Zhoudunming Tu, Zhongbao Yin, Liang Zheng

Abstract: The upcoming Electron-Ion Collider (EIC) will address several outstanding puzzles in modern nuclear physics. Topics such as the partonic structure of nucleons and nuclei, the origin of their mass and spin, among others, can be understood via the study of high energy electron-proton ($ep$) and electron-nucleus ($e$A) collisions. Achieving the scientific goals of the EIC will require a novel electro… ▽ More The upcoming Electron-Ion Collider (EIC) will address several outstanding puzzles in modern nuclear physics. Topics such as the partonic structure of nucleons and nuclei, the origin of their mass and spin, among others, can be understood via the study of high energy electron-proton ($ep$) and electron-nucleus ($e$A) collisions. Achieving the scientific goals of the EIC will require a novel electron-hadron collider and detectors capable to perform high-precision measurements, but also dedicated tools to model and interpret the data. To aid in the latter, we present a general-purpose $e$A Monte Carlo (MC) generator - BeAGLE. In this paper, we provide a general description of the models integrated into BeAGLE, applications of BeAGLE in $e$A physics, implications for detector requirements at the EIC, and the tuning of the parameters in BeAGLE based on available experimental data. Specifically, we focus on a selection of model and data comparisons in particle production in both $ep$ and $e$A collisions, where baseline particle distributions provide essential information to characterize the event. In addition, we investigate the collision geometry determination in $e$A collisions, which could be used as an experimental tool for varying the nuclear density. △ Less

Submitted 13 April, 2022; originally announced April 2022.

Comments: Manuscript with 20 pages, 16 figures, and 3 tables

Low-Energy Physics in Neutrino LArTPCs

Authors: D. Caratelli, W. Foreman, A. Friedland, S. Gardiner, I. Gil-Botella, G. Karagiorgi, M. Kirby, G. Lehmann Miotto, B. R. Littlejohn, M. Mooney, J. Reichenbacher, A. Sousa, K. Scholberg, J. Yu, T. Yang, S. Andringa, J. Asaadi, T. J. C. Bezerra, F. Capozzi, F. Cavanna, E. Church, A. Himmel, T. Junk, J. Klein, I. Lepetic , et al. (264 additional authors not shown)

Abstract: In this white paper, we outline some of the scientific opportunities and challenges related to detection and reconstruction of low-energy (less than 100 MeV) signatures in liquid argon time-projection chamber (LArTPC) detectors. Key takeaways are summarized as follows. 1) LArTPCs have unique sensitivity to a range of physics and astrophysics signatures via detection of event features at and below… ▽ More In this white paper, we outline some of the scientific opportunities and challenges related to detection and reconstruction of low-energy (less than 100 MeV) signatures in liquid argon time-projection chamber (LArTPC) detectors. Key takeaways are summarized as follows. 1) LArTPCs have unique sensitivity to a range of physics and astrophysics signatures via detection of event features at and below the few tens of MeV range. 2) Low-energy signatures are an integral part of GeV-scale accelerator neutrino interaction final states, and their reconstruction can enhance the oscillation physics sensitivities of LArTPC experiments. 3) BSM signals from accelerator and natural sources also generate diverse signatures in the low-energy range, and reconstruction of these signatures can increase the breadth of BSM scenarios accessible in LArTPC-based searches. 4) Neutrino interaction cross sections and other nuclear physics processes in argon relevant to sub-hundred-MeV LArTPC signatures are poorly understood. Improved theory and experimental measurements are needed. Pion decay-at-rest sources and charged particle and neutron test beams are ideal facilities for experimentally improving this understanding. 5) There are specific calibration needs in the low-energy range, as well as specific needs for control and understanding of radiological and cosmogenic backgrounds. 6) Novel ideas for future LArTPC technology that enhance low-energy capabilities should be explored. These include novel charge enhancement and readout systems, enhanced photon detection, low radioactivity argon, and xenon doping. 7) Low-energy signatures, whether steady-state or part of a supernova burst or larger GeV-scale event topology, have specific triggering, DAQ and reconstruction requirements that must be addressed outside the scope of conventional GeV-scale data collection and analysis pathways. △ Less

Submitted 1 March, 2022; originally announced March 2022.

Comments: Contribution to Snowmass 2021

Autofocusing Self-Imaging: The Symmetric Pearcey Talbot-like Effect

Authors: Jiajia Zhao, You Wu, Zejia Lin, Danlin Xu, Haiqi Huang, Chuangjie Xu, Zhifeng Tu, Hongzhan Liu, Lingling Shui, Dongmei Deng

Abstract: The Talbot like effect of symmetric Pearcey beams (SPBs) is presented numerically and experimentally in the free space. Owing to the Talbot like effect, the SPBs have the property of periodic and multiple autofocusing. Meanwhile, the focal positions and focal times of SPBs are controlled by the beam shift factor and the distribution factors. What is more, the beam shift factor can also affect the… ▽ More The Talbot like effect of symmetric Pearcey beams (SPBs) is presented numerically and experimentally in the free space. Owing to the Talbot like effect, the SPBs have the property of periodic and multiple autofocusing. Meanwhile, the focal positions and focal times of SPBs are controlled by the beam shift factor and the distribution factors. What is more, the beam shift factor can also affect the Talbot-like effect and the Talbot period. Therefore, several tiny optical bottles can be generated under the appropriate parameter setting. It is believed that the results can diversify the application of the Talbot effect. △ Less

Submitted 19 December, 2021; originally announced December 2021.

Comments: 11 pages, 6 figures

Exploring fundamental laws of classical mechanics via predicting the orbits of planets based on neural networks

Authors: Jian Zhang, Yiming Liu, Z. C. Tu

Abstract: Neural networks have provided powerful approaches to solve various scientific problems. Many of them are even difficult for human experts who are good at accessing the physical laws from experimental data. We investigate whether neural networks can assist us in exploring the fundamental laws of classical mechanics from data of planetary motion. Firstly, we predict the orbits of planets in the geoc… ▽ More Neural networks have provided powerful approaches to solve various scientific problems. Many of them are even difficult for human experts who are good at accessing the physical laws from experimental data. We investigate whether neural networks can assist us in exploring the fundamental laws of classical mechanics from data of planetary motion. Firstly, we predict the orbits of planets in the geocentric system using the gate recurrent unit, one of the common neural networks. We find that the precision of the prediction is obviously improved when the information of the Sun is included in the training set. This result implies that the Sun is particularly important in the geocentric system without any prior knowledge, which inspires us to gain Copernicus' heliocentric theory. Secondly, we turn to the heliocentric system and make successfully mutual predictions between the position and velocity of planets. We hold that the successful prediction is due to the existence of enough conserved quantities (such as conservations of mechanical energy and angular momentum) in the system. Our research provides a new way to explore the existence of conserved quantities in mechanics system based on neural networks. △ Less

Submitted 7 September, 2022; v1 submitted 2 December, 2021; originally announced December 2021.

Journal ref: Chin. Phys. B, 2022, Vol. 31(9): 094502

XCloud-VIP: Virtual Peak Enables Highly Accelerated NMR Spectroscopy and Faithful Quantitative Measures

Authors: Di Guo, Zhangren Tu, Yi Guo, Yirong Zhou, Jian Wang, Zi Wang, Tianyu Qiu, Min Xiao, Yinran Chen, Liubin Feng, Yuqing Huang, Donghai Lin, Qing Hong, Amir Goldbourt, Meijin Lin, Xiaobo Qu

Abstract: Nuclear Magnetic Resonance (NMR) spectroscopy is an important bio-engineering tool to determine the metabolic concentrations, molecule structures and so on. The data acquisition time, however, is very long in multi-dimensional NMR. To accelerate data acquisition, non-uniformly sampling is an effective way but may encounter severe spectral distortions and unfaithful quantitative measures when the a… ▽ More Nuclear Magnetic Resonance (NMR) spectroscopy is an important bio-engineering tool to determine the metabolic concentrations, molecule structures and so on. The data acquisition time, however, is very long in multi-dimensional NMR. To accelerate data acquisition, non-uniformly sampling is an effective way but may encounter severe spectral distortions and unfaithful quantitative measures when the acceleration factor is high. By modelling the acquired signal as the superimposed exponentials, we proposed a virtual peak (VIP) approach to selfadapt the prior spectral information, such as the resonance frequency and peak lineshape, and then feed these information into the reconstruction. The proposed method is further implemented with cloud computing to facilitate online, open, and easy access. Results on simulated and experimental data demonstrate that, compared with the low-rank Hankel matrix method, the new approach reconstructs high-fidelity NMR spectra from highly undersampled data and achieves more accurate quantification. The maximum quantitative errors of distances between nuclear pairs and concentrations of metabolites in mixtures have been reduced by 61.1% and 57.7%, respectively. △ Less

Submitted 19 October, 2023; v1 submitted 22 March, 2021; originally announced March 2021.

Science Requirements and Detector Concepts for the Electron-Ion Collider: EIC Yellow Report

Authors: R. Abdul Khalek, A. Accardi, J. Adam, D. Adamiak, W. Akers, M. Albaladejo, A. Al-bataineh, M. G. Alexeev, F. Ameli, P. Antonioli, N. Armesto, W. R. Armstrong, M. Arratia, J. Arrington, A. Asaturyan, M. Asai, E. C. Aschenauer, S. Aune, H. Avagyan, C. Ayerbe Gayoso, B. Azmoun, A. Bacchetta, M. D. Baker, F. Barbosa, L. Barion , et al. (390 additional authors not shown)

Abstract: This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Collider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon… ▽ More This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Collider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nuclei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were commissioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimental equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter △ Less

Submitted 26 October, 2021; v1 submitted 8 March, 2021; originally announced March 2021.

Comments: 902 pages, 415 authors, 151 institutions

Report number: BNL-220990-2021-FORE, JLAB-PHY-21-3198, LA-UR-21-20953

Journal ref: Nucl. Phys. A 1026 (2022) 122447

A Sparse Model-inspired Deep Thresholding Network for Exponential Signal Reconstruction -- Application in Fast Biological Spectroscopy

Authors: Zi Wang, Di Guo, Zhangren Tu, Yihui Huang, Yirong Zhou, Jian Wang, Liubin Feng, Donghai Lin, Yongfu You, Tatiana Agback, Vladislav Orekhov, Xiaobo Qu

Abstract: The non-uniform sampling is a powerful approach to enable fast acquisition but requires sophisticated reconstruction algorithms. Faithful reconstruction from partial sampled exponentials is highly expected in general signal processing and many applications. Deep learning has shown astonishing potential in this field but many existing problems, such as lack of robustness and explainability, greatly… ▽ More The non-uniform sampling is a powerful approach to enable fast acquisition but requires sophisticated reconstruction algorithms. Faithful reconstruction from partial sampled exponentials is highly expected in general signal processing and many applications. Deep learning has shown astonishing potential in this field but many existing problems, such as lack of robustness and explainability, greatly limit its applications. In this work, by combining merits of the sparse model-based optimization method and data-driven deep learning, we propose a deep learning architecture for spectra reconstruction from undersampled data, called MoDern. It follows the iterative reconstruction in solving a sparse model to build the neural network and we elaborately design a learnable soft-thresholding to adaptively eliminate the spectrum artifacts introduced by undersampling. Extensive results on both synthetic and biological data show that MoDern enables more robust, high-fidelity, and ultra-fast reconstruction than the state-of-the-art methods. Remarkably, MoDern has a small number of network parameters and is trained on solely synthetic data while generalizing well to biological data in various scenarios. Furthermore, we extend it to an open-access and easy-to-use cloud computing platform (XCloud-MoDern), contributing a promising strategy for further development of biological applications. △ Less

Submitted 17 January, 2022; v1 submitted 29 December, 2020; originally announced December 2020.

Comments: 30 pages

Dynamics of active nematic defects on the surface of a sphere

Authors: Yi-Heng Zhang, Markus Deserno, Zhan-Chun Tu

Abstract: A nematic liquid crystal confined to the surface of a sphere exhibits topological defects of total charge $+2$ due to the topological constraint. In equilibrium, the nematic field forms four $+1/2$ defects, located at the corners of a regular tetrahedron inscribed within the sphere, since this minimizes the Frank elastic energy. If additionally the individual nematogens exhibit self-driven directi… ▽ More A nematic liquid crystal confined to the surface of a sphere exhibits topological defects of total charge $+2$ due to the topological constraint. In equilibrium, the nematic field forms four $+1/2$ defects, located at the corners of a regular tetrahedron inscribed within the sphere, since this minimizes the Frank elastic energy. If additionally the individual nematogens exhibit self-driven directional motion, the resulting active system creates large-scale flow that drives it out of equilibrium. In particular, the defects now follow complex dynamic trajectories which, depending on the strength of the active forcing, can be periodic (for weak forcing) or chaotic (for strong forcing). In this paper we derive an effective particle theory for this system, in which the topological defects are the degrees of freedom, whose exact equations of motion we subsequently determine. Numerical solutions of these equations confirm previously observed characteristics of their dynamics and clarify the role played by the time dependence of their global rotation. We also show that Onsager's variational principle offers an exceptionally transparent way to derive these dynamical equations, and we explain the defect mobility at the hydrodynamics level. △ Less

Submitted 20 July, 2020; v1 submitted 4 June, 2020; originally announced June 2020.

Comments: 16 pages, 7 figures

Journal ref: Phys. Rev. E 102, 012607 (2020)

Sparse-GAN: Sparsity-constrained Generative Adversarial Network for Anomaly Detection in Retinal OCT Image

Authors: Kang Zhou, Shenghua Gao, Jun Cheng, Zaiwang Gu, Huazhu Fu, Zhi Tu, Jianlong Yang, Yitian Zhao, Jiang Liu

Abstract: With the development of convolutional neural network, deep learning has shown its success for retinal disease detection from optical coherence tomography (OCT) images. However, deep learning often relies on large scale labelled data for training, which is oftentimes challenging especially for disease with low occurrence. Moreover, a deep learning system trained from data-set with one or a few dise… ▽ More With the development of convolutional neural network, deep learning has shown its success for retinal disease detection from optical coherence tomography (OCT) images. However, deep learning often relies on large scale labelled data for training, which is oftentimes challenging especially for disease with low occurrence. Moreover, a deep learning system trained from data-set with one or a few diseases is unable to detect other unseen diseases, which limits the practical usage of the system in disease screening. To address the limitation, we propose a novel anomaly detection framework termed Sparsity-constrained Generative Adversarial Network (Sparse-GAN) for disease screening where only healthy data are available in the training set. The contributions of Sparse-GAN are two-folds: 1) The proposed Sparse-GAN predicts the anomalies in latent space rather than image-level; 2) Sparse-GAN is constrained by a novel Sparsity Regularization Net. Furthermore, in light of the role of lesions for disease screening, we present to leverage on an anomaly activation map to show the heatmap of lesions. We evaluate our proposed Sparse-GAN on a publicly available dataset, and the results show that the proposed method outperforms the state-of-the-art methods. △ Less

Submitted 3 February, 2020; v1 submitted 27 November, 2019; originally announced November 2019.

Comments: Accepted to ISBI 2020

General neck condition for the limit shape of budding vesicles

Authors: Pan Yang, Qiang Du, Z. C. Tu

Abstract: The shape equation and linking conditions for a vesicle with two-phase domains are derived. We refine the conjecture on the general neck condition for the limit shape of a budding vesicle proposed by Jülicher and Lipowsky [Phys. Rev. Lett. \textbf{70}, 2964 (1993); Phys. Rev. E \textbf{53}, 2670 (1996)], and then we use the shape equation and linking conditions to prove that this conjecture holds… ▽ More The shape equation and linking conditions for a vesicle with two-phase domains are derived. We refine the conjecture on the general neck condition for the limit shape of a budding vesicle proposed by Jülicher and Lipowsky [Phys. Rev. Lett. \textbf{70}, 2964 (1993); Phys. Rev. E \textbf{53}, 2670 (1996)], and then we use the shape equation and linking conditions to prove that this conjecture holds not only for axisymmetric budding vesicles, but also for asymmetric ones. Our study reveals that the mean curvature at any point on the membrane segments adjacent to the neck satisfies the general neck condition for the limit shape of a budding vesicle when the length scale of the membrane segments is much larger than the characteristic size of the neck but still much smaller than the characteristic size of the vesicle. △ Less

Submitted 4 April, 2017; v1 submitted 10 August, 2015; originally announced August 2015.

Comments: 11 pages, 4 figures

Journal ref: Phys. Rev. E 95, 042403 (2017)

Recent theoretical advances in elasticity of membranes following Helfrich's spontaneous curvature model

Authors: Z. C. Tu, Z. C. Ou-Yang

Abstract: Recent theoretical advances in elasticity of membranes following Helfrich's famous spontaneous curvature model are summarized in this review. The governing equations describing equilibrium configurations of lipid vesicles, lipid membranes with free edges, and chiral lipid membranes are presented. Several analytic solutions to these equations and their corresponding configurations are demonstrated. Recent theoretical advances in elasticity of membranes following Helfrich's famous spontaneous curvature model are summarized in this review. The governing equations describing equilibrium configurations of lipid vesicles, lipid membranes with free edges, and chiral lipid membranes are presented. Several analytic solutions to these equations and their corresponding configurations are demonstrated. △ Less

Submitted 4 May, 2014; originally announced May 2014.

Comments: 10 pages, 8 figures

Journal ref: Adv. Colloid. Interface Sci. 208 (2014) 66-75

Challenges in theoretical investigations on configurations of lipid membranes

Authors: Z. C. Tu

Abstract: This review reports some key results in theoretical investigations on configurations of lipid membranes and presents several challenges in this field which involve (i) exact solutions to the shape equation of lipid vesicles; (ii) exact solutions to the governing equations of open lipid membranes; (iii) neck condition of two-phase vesicles in the budding state; (iv) nonlocal theory of membrane elas… ▽ More This review reports some key results in theoretical investigations on configurations of lipid membranes and presents several challenges in this field which involve (i) exact solutions to the shape equation of lipid vesicles; (ii) exact solutions to the governing equations of open lipid membranes; (iii) neck condition of two-phase vesicles in the budding state; (iv) nonlocal theory of membrane elasticity; (v) relationship between symmetry and the magnitude of free energy. △ Less

Submitted 24 January, 2013; v1 submitted 22 December, 2012; originally announced December 2012.

Comments: Chin. Phys. B 22, 028701 (2013)

Journal ref: Chin. Phys. B 22, 028701 (2013)

Bounds and phase diagram of efficiency at maximum power for tight-coupling molecular motors

Authors: Z. C. Tu

Abstract: The efficiency at maximum power (EMP) for tight-coupling molecular motors is investigated within the framework of irreversible thermodynamics. It is found that the EMP depends merely on the constitutive relation between the thermodynamic current and force. The motors are classified into four generic types (linear, superlinear, sublinear, and mixed types) according to the characteristics of the con… ▽ More The efficiency at maximum power (EMP) for tight-coupling molecular motors is investigated within the framework of irreversible thermodynamics. It is found that the EMP depends merely on the constitutive relation between the thermodynamic current and force. The motors are classified into four generic types (linear, superlinear, sublinear, and mixed types) according to the characteristics of the constitutive relation, and then the corresponding ranges of the EMP for these four types of molecular motors are obtained. The exact bounds of the EMP are derived and expressed as the explicit functions of the free energy released by the fuel in each motor step. A phase diagram is constructed which clearly shows how the region where the parameters (the load distribution factor and the free energy released by the fuel in each motor step) are located can determine whether the value of the EMP is larger or smaller than 1/2. This phase diagram reveals that motors using ATP as fuel under physiological conditions can work at maximum power with higher efficiency ($>1/2$) for a small load distribution factor ($<0.1$). △ Less

Submitted 7 February, 2013; v1 submitted 13 August, 2012; originally announced August 2012.

Comments: 5 pages, 4 figures

Journal ref: Eur. Phys. J. E 36, 11 (2013)

Geometry of membranes

Authors: Z. C. TU

Abstract: This review reports some theoretical results on the Geometry of membranes. The governing equations to describe equilibrium configurations of lipid vesicles, lipid membranes with free edges, and chiral lipid membranes are derived from the variation of free energies of these structures. Some analytic solutions to these equations and their corresponding configurations are also shown. This review reports some theoretical results on the Geometry of membranes. The governing equations to describe equilibrium configurations of lipid vesicles, lipid membranes with free edges, and chiral lipid membranes are derived from the variation of free energies of these structures. Some analytic solutions to these equations and their corresponding configurations are also shown. △ Less

Submitted 26 December, 2011; v1 submitted 12 June, 2011; originally announced June 2011.

Comments: Review for JGSP. 31 pages, 13 figures

Journal ref: Journal of Geometry and Symmetry in Physics 24 (2011) 45-75

Compatibility between shape equation and boundary conditions of lipid membranes with free edges

Authors: Z. C. Tu

Abstract: Only some special open surfaces satisfying the shape equation of lipid membranes can be compatible with the boundary conditions. As a result of this compatibility, the first integral of the shape equation should vanish for axisymmetric lipid membranes, from which two theorems of non-existence are verified: (i) There is no axisymmetric open membrane being a part of torus satisfying the shape equa… ▽ More Only some special open surfaces satisfying the shape equation of lipid membranes can be compatible with the boundary conditions. As a result of this compatibility, the first integral of the shape equation should vanish for axisymmetric lipid membranes, from which two theorems of non-existence are verified: (i) There is no axisymmetric open membrane being a part of torus satisfying the shape equation; (ii) There is no axisymmetric open membrane being a part of a biconcave discodal surface satisfying the shape equation. Additionally, the shape equation is reduced to a second-order differential equation while the boundary conditions are reduced to two equations due to this compatibility. Numerical solutions to the reduced shape equation and boundary conditions agree well with the experimental data [A. Saitoh \emph{et al.}, Proc. Natl. Acad. Sci. USA \textbf{95}, 1026 (1998)]. △ Less

Submitted 25 February, 2010; v1 submitted 1 September, 2009; originally announced September 2009.

Comments: 6 journal pages, 4 figures

Journal ref: J. Chem. Phys. 132, 084111 (2010)

Theoretical and numerical investigations on shapes of planar lipid monolayer domains

Authors: Hao Wu, Z. C. Tu

Abstract: Shapes of planar lipid monolayer domains at the air-water interface are theoretically and numerically investigated by minimizing the formation energy of the domains which consist of the surface energy, line tension energy, and dipole electrostatic energy. The shape equation which describes boundary curves of the domains at equilibrium state is derived from the first order variation of the format… ▽ More Shapes of planar lipid monolayer domains at the air-water interface are theoretically and numerically investigated by minimizing the formation energy of the domains which consist of the surface energy, line tension energy, and dipole electrostatic energy. The shape equation which describes boundary curves of the domains at equilibrium state is derived from the first order variation of the formation energy. A relaxation method is proposed to find the numerical solutions of the shape equation. The theoretical and numerical results are in good agreement with previous experimental observation. Some new shapes not observed in previous experiments are also obtained, which awaits experimental confirmation in the future. △ Less

Submitted 8 December, 2008; v1 submitted 11 October, 2008; originally announced October 2008.

Comments: 16 pages with 14 figures, revised version accepted by J. Chem. Phys

Journal ref: J. Chem. Phys. 130, 045103 (2009)

Elastic theory of low-dimensional continua and its applications in bio- and nano-structures

Authors: Z. C. Tu, Z. C. Ou-Yang

Abstract: This review presents the elastic theory of low-dimensional (one- and two-dimensional) continua and its applications in bio- and nano-structures. First, the curve and surface theory, as the geometric representation of the low-dimensional continua, is briefly described through Cartan moving frame method. The elastic theory of Kirchhoff rod, Helfrich rod, bending-soften rod, fluid membrane, and sol… ▽ More This review presents the elastic theory of low-dimensional (one- and two-dimensional) continua and its applications in bio- and nano-structures. First, the curve and surface theory, as the geometric representation of the low-dimensional continua, is briefly described through Cartan moving frame method. The elastic theory of Kirchhoff rod, Helfrich rod, bending-soften rod, fluid membrane, and solid shell is revisited. Secondly, the application and availability of the elastic theory of low-dimensional continua in bio-structures, including short DNA rings, lipid membranes, and cell membranes, are discussed. The kink stability of short DNA rings is addressed by using the theory of Kirchhoff rod, Helfrich rod, and bending-soften rod. The lipid membranes obey the theory of fluid membrane. A cell membrane is simplified as a composite shell of lipid bilayer and membrane skeleton, which is a little similar to the solid shell. It is found that the membrane skeleton enhances highly the mechanical stability of cell membranes. Thirdly, the application and availability of the elastic theory of low-dimensional continua in nano-structures, including graphene and carbon nanotubes, are discussed. A revised Lenosky lattice model is proposed based on the local density approximation. Its continuum form up to the second order terms of curvatures and strains is the same as the free energy of 2D solid shells. Several typical mechanical properties of carbon nanotubes are revisited and investigated based on this continuum form. It is possible to avoid introducing the controversial concepts, the Young's modulus and thickness of graphene and single-walled carbon nanotubes, with this continuum form. △ Less

Submitted 1 June, 2008; v1 submitted 1 June, 2007; originally announced June 2007.

Comments: Review article for J. Comput. Theor. Nanosci., 27 pages, 15 figures

Journal ref: J. Comput. Theor. Nanosci. 5, 422-448 (2008)