E5F8
Skip to content
Fulcrum Genomics

Hi there 👋

Fulcrum Genomics Speaks Biology.

We are bioinformaticians, computational biologists, and software engineers with experience in basic research, technology development, diagnostics, therapeutics and beyond. Talk to us about your problem –- we’ll understand.

Below are Toolkits, Libraries, and Template Repositories that we've developed and use on a regular basis. We hope that you will find them useful too!

  • We prefer to publish under the MIT License; Forked repositories normally retain their original license and thus may be published under a different license.
  • We have a Code of Conduct

Toolkits 🛠️

Here are some toolkits we've developed:

  • fgbio: Tools for working with genomic and high throughput sequencing data in Scala.
  • fgsv: Tools to gather evidence for structural variation via breakpoint detection.
  • fqtk: Fast FASTQ sample demultiplexing in Rust.
  • fqgrep: Grep for FASTQ files.
  • stitch: Stitch is a toolkit for analysis of chimeric reads in sequencing data.
  • guide-counter: A better, faster way to count guides in CRISPR screens.
  • bwa: A fork of bwa to run interactively and work with bwa on the command line.

Libraries 📚

Here are some libraries that we use regularly in our work:

  • Python
    • fgpyo: Quality of life improvements for Bioinformatics in Python.
    • pybedlite: Lightweight interfaces for reading, writing, and querying Genomic Regions (BED) in Python.
    • prymer: APIs and wrappers for performing PCR primer design and related tasks in Python.
  • Rust
    • fgoxide: Quality of life improvements for Bioinformatics in Rust.
    • read-structure: Read structures in Rust.
    • pooled-writer: A pooled writer and compressor library in Rust.
    • bgzf: High level readers and writers for the BGZF format in Rust.
  • Scala
    • fgprimer: APIs and wrappers for performing PCR primer design and related tasks in Scala.
    • sopt: An argument parsing library for Scala.
    • commons: A collection of useful libraries for Scala.
  • GitHub Actions
    • setup-latch: A GitHub action for building and register Latch Bio workflows.
10BC0

Pinned Loading

  1. fgbio fgbio Public

    Tools for working with genomic and high throughput sequencing data.

    Scala 363 76

  2. fqgrep fqgrep Public

    Grep for FASTQ files

    Rust 104 4

  3. guide-counter guide-counter Public

    A better, faster way to count guides in CRISPR screens.

    Rust 34 3

  4. fqtk fqtk Public

    Fast FASTQ sample demultiplexing in Rust.

    Rust 67 2

  5. pybedlite pybedlite Public

    Lightweight Python interfaces for reading, writing, and querying genomic regions (BED)

    Python 15 1

  6. fgoxide fgoxide Public

    Quality of life improvements in Rust.

    Rust 6 3

Repositories

Showing 10 of 73 repositories
  • fgumi Public

    High-performance UMI tools for NGS data analysis

    fulcrumgenomics/fgumi’s past year of commit activity
    Rust 40 MIT 1 8 22 Updated Apr 18, 2026
  • nf-core-modules Public Forked from nf-core/modules

    Repository to host tool-specific module files for the Nextflow DSL2 community!

    fulcrumgenomics/nf-core-modules’s past year of commit activity
    Nextflow 0 MIT 1,041 0 1 Updated Apr 18, 2026
  • fgbio Public

    Tools for working with genomic and high throughput sequencing data.

    fulcrumgenomics/fgbio’s past year of commit activity
    Scala 363 MIT 76 47 (19 issues need help) 21 Updated Apr 18, 2026
  • fqtk Public

    Fast FASTQ sample demultiplexing in Rust.

    fulcrumgenomics/fqtk’s past year of commit activity
    Rust 67 MIT 2 7 (1 issue needs help) 9 Updated Apr 17, 2026
  • fgpyo Public

    Quality of life improvements for Bioinformatics in Python.

    fulcrumgenomics/fgpyo’s past year of commit activity
    Python 32 4 25 (1 issue needs help) 3 Updated Apr 16, 2026
  • pooled-writer Public

    A pooled writer and compressor library in Rust.

    fulcrumgenomics/pooled-writer’s past year of commit activity
    Rust 4 MIT 0 0 0 Updated Apr 15, 2026
  • bioconda-recipes Public Forked from bioconda/bioconda-recipes

    Conda recipes for the bioconda channel.

    fulcrumgenomics/bioconda-recipes’s past year of commit activity
    Shell 0 MIT 3,882 0 0 Updated Apr 13, 2026
  • riker Public

    Spiritual successor to picard for sequencing qc

    fulcrumgenomics/riker’s past year of commit activity
    Rust 4 MIT 2 0 1 Updated Apr 10, 2026
  • twistcgp Public

    Nextflow pipeline for Twist Comprehensive Genomic Profiling (CGP) panel analysis

    fulcrumgenomics/twistcgp’s past year of commit activity
    Nextflow 3 1 16 2 Updated Apr 9, 2026
  • jlibdeflate Public

    Java JNI wrapper around libdeflate for faster DEFLATE/gzip/zip on the JVM

    fulcrumgenomics/jlibdeflate’s past year of commit activity
    Java 2 MIT 0 0 1 Updated Apr 8, 2026

Top languages

Loading…

Most used topics

Loading…

0