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Protein corona composition of PEGylated nanoparticles correlates strongly with amino acid composition of protein surface
Authors:
Giovanni Settanni,
Jiajia Zhou,
Tongchuan Suo,
Susanne Schöttler,
Katharina Landfester,
Friederike Schmid,
Volker Mailänder
Abstract:
Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol)(PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding polar ones. A solvent-accessible-surface-area model of protein adsorption on PEGylated nanoparticles accurately fits a large set of data on the co…
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Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol)(PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding polar ones. A solvent-accessible-surface-area model of protein adsorption on PEGylated nanoparticles accurately fits a large set of data on the composition of the protein corona recently obtained by label-free proteomic mass spectrometry.
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Submitted 28 December, 2016;
originally announced December 2016.
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Macro deformation twins in single-crystal aluminum
Authors:
F. Zhao,
L. Wang,
D. Fan,
B. X. Bie,
X. M. Zhou,
T. Suo,
Y. L. Li,
M. W. Chen,
C. Liu,
M. L. Qi,
M. H. Zhu,
S. N. Luo
Abstract:
Deformation twinning in pure aluminum has been considered to be a unique property of nanostructured aluminum. A lingering mystery is whether deformation twinning occurs in coarse-grained or single-crystal aluminum, at scales beyond nanotwins. Here, we present the first experimental demonstration of macro deformation twins in single-crystal aluminum formed under ultrahigh strain-rate ($\sim$10$^6$…
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Deformation twinning in pure aluminum has been considered to be a unique property of nanostructured aluminum. A lingering mystery is whether deformation twinning occurs in coarse-grained or single-crystal aluminum, at scales beyond nanotwins. Here, we present the first experimental demonstration of macro deformation twins in single-crystal aluminum formed under ultrahigh strain-rate ($\sim$10$^6$ s$^{-1}$), large shear strain (200$\%$) via dynamic equal channel angular pressing. Deformation twinning is rooted in the rate dependences of dislocation motion and twinning, which are coupled, complementary processes during severe plastic deformation under ultrahigh strain rates.
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Submitted 15 October, 2015;
originally announced October 2015.
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The Phase Behaviors of A Polymer Solution Confined between Two Concentric Cylinders
Authors:
Tongchuan Suo,
Dadong Yan
Abstract:
A theoretical study on the phase behaviors of a polymer solution confined between two coaxial cylindrical walls is presented. For the case of a neutral inner cylinder, the spinodal point derived through the Gaussian fluctuation theory is confinement-independent because of the existence of a free dimension in the system. The kinetic analysis indicates that the fluctuation modes always have a comp…
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A theoretical study on the phase behaviors of a polymer solution confined between two coaxial cylindrical walls is presented. For the case of a neutral inner cylinder, the spinodal point derived through the Gaussian fluctuation theory is confinement-independent because of the existence of a free dimension in the system. The kinetic analysis indicates that the fluctuation modes always have a component of a plane wave along the axial direction, which can lead to the formation of a periodic-like concentration pattern. On the other hand, the equilibrium structure of the system is obtained by using the self-consistent mean-field theory (SCMFT) and the interplay between the "wetting" phenomenon and the phase separation is observed by modifying the property of the inner cylinderical wall.
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Submitted 22 September, 2009;
originally announced September 2009.