Showing 1–50 of 174 results for author: Ge, R

Fast Object Removal Attacks on Safety-Critical Video-based Perception Systems

Authors: Mohammad Imtiaz Hasan, M Sabbir Salek, Nathan Jones, Mashrur Chowdhury, Rong Ge

Abstract: By leveraging data from video-based perception systems, intelligent transportation systems (ITS) support safety-critical applications that improve road safety. However, adversaries may manipulate video frames to compromise downstream perception modules, causing failures in safety-critical functions and increasing risks to vulnerable road users. This paper presents a novel attack model and an end-t… ▽ More By leveraging data from video-based perception systems, intelligent transportation systems (ITS) support safety-critical applications that improve road safety. However, adversaries may manipulate video frames to compromise downstream perception modules, causing failures in safety-critical functions and increasing risks to vulnerable road users. This paper presents a novel attack model and an end-to-end framework for near-real-time targeted object removal attack on a video-based safety-critical system. The end-to-end attack pipeline consists of four stages: localizing targets in each frame, retrieving coherent patches from earlier frames, blending them using context-aware alpha compositing, and reconstructing attacked frames. Experiments at an intersection on the South Carolina Connected Vehicle Testbed (SC-CVT) show that reconstructed frames have high global similarity to the originals, with frame-level Peak Signal to Noise Ratio (PSNR) above 40 dB and Structural Similarity Index Measure (SSIM) above 0.996. Using the YOLO-based detector, the attack reduces object detections by up to 97.59% and achieves a frame-level attack success rate of 94.48%. Across the evaluated detectors and frame resolutions, the mean execution time ranges from 0.074 to 0.172 seconds per frame on GPU hardware, indicating near-real-time performance in testing. The forensic evaluation using several pretrained tamper-detection models shows limited ability to distinguish reconstructed from authentic frames. The findings suggest that video-based perception is vulnerable to stealthy object removal attacks that can degrade the performance of safety-critical applications by reducing object detectability. These findings can help develop mitigation strategies against adversarial object removal attacks that threaten safety-critical applications, such as vision-based pedestrian safety systems. △ Less

Submitted 3 August, 2026; originally announced August 2026.

MEDA: Measurement-Efficient Disorder-Aware Majorana Zero Mode Detection in Realistic Devices

Authors: Nathan Jones, Binayyak Roy, Valentine Mohaugen, Ian Lewis, Toby Cox, Sumanta Tewari, Rong Ge

Abstract: Fault-tolerant topological quantum computing relies on identifying Majorana zero modes (MZMs), but reliable detection in realistic devices remains challenging. Conventional topological indicators are inherently biased in finite, disordered systems, blurring the distinction between true MZMs and trivial states. Furthermore, attempts to map these indicators to real observables via machine learning r… ▽ More Fault-tolerant topological quantum computing relies on identifying Majorana zero modes (MZMs), but reliable detection in realistic devices remains challenging. Conventional topological indicators are inherently biased in finite, disordered systems, blurring the distinction between true MZMs and trivial states. Furthermore, attempts to map these indicators to real observables via machine learning require dense, expensive conductance measurements, creating a severe scaling bottleneck. To simultaneously address topological bias and measurement limitations, we present MEDA: a Measurement-Efficient, Disorder-Aware framework for MZM detection in realistic devices. MEDA maps sparse, practically obtainable observables directly to the robust periodic disorder invariant (PDI). Using a novel sparse parameter regime, MEDA reduces measurement volume by 10x while maintaining predictive quality, even in moderate to strong disorder regimes that limit conventional methods. Furthermore, MEDA naturally prioritizes input features consistent with the topological gap protocol, demonstrating strong physical interpretability. △ Less

Submitted 16 August, 2026; v1 submitted 28 July, 2026; originally announced July 2026.

Comments: Accepted to 2026 IEEE International Conference on Quantum Computing and Engineering

Understanding From Human Perspective: A Multi-agent System for Interactive Egocentric Medical Image Segmentation

Authors: Rongjun Ge, Dongyang Wang, Heng Zhu, Zhirui Li, Yang Chen, Yuting He

Abstract: Interactive egocentric medical image segmentation (IEMIS) plays an important role in smart-glasses-assisted medical image review, segmenting the medical targets a clinician refers to from their egocentric view. Once it succeeds, the object-level visual evidence it provides strengthens the review and underpins fine-grained analysis and clinical decision-making. However, the instruction and the vide… ▽ More Interactive egocentric medical image segmentation (IEMIS) plays an important role in smart-glasses-assisted medical image review, segmenting the medical targets a clinician refers to from their egocentric view. Once it succeeds, the object-level visual evidence it provides strengthens the review and underpins fine-grained analysis and clinical decision-making. However, the instruction and the video both come from the user's egocentric perspective, which poses two challenges. (1) Semantic ambiguity leaves the model unable to confirm the user-intended target. (2) Visual variability makes the segmentation jump from frame to frame. In this paper, we propose EgoMed-Agent, a multi-agent system that understands the target from the human perspective through two workflows. (1) The \textit{Target Confirmation Workflow} grounds the instruction against candidate targets with a reliability score, confirming the target when the grounding is reliable and asking the user to clarify when it is not, thereby confirming the segmentation target. (2) The \textit{Localization-Guided Propagation Workflow} couples mask propagation with per-frame target localization, using the localized target to correct the propagated mask whenever the two diverge, so the segmentation stays on the target across the egocentric video. Extensive experiments show that EgoMed-Agent reaches 71.34\% average Dice, far above the best text-prompted baseline (11.70\%). Our code is available at \href{https://github.com/wdyyyyyy/EgoMed-Agent}{our project page}. △ Less

Submitted 19 July, 2026; originally announced July 2026.

From Data Completeness to Data Sufficiency: A Task-Driven Imaging Framework for Intraoperative CBCT under Quality-Time-Dose Trade-offs

Authors: Yi Jia, Rongjun Ge, Yang Chen, Yan Xi, Wenjun Xia

Abstract: Mobile C-arm cone-beam computed tomography (CBCT) has been widely used for real-time intraoperative 3D imaging. However, current practice often mechanically applies the fan-beam CT criterion of "180° plus fan angle" in pursuit of "data completeness" in reconstruction. This review argues that, under the single circular trajectory of three-dimensional cone-beam geometry, complete data are mathematic… ▽ More Mobile C-arm cone-beam computed tomography (CBCT) has been widely used for real-time intraoperative 3D imaging. However, current practice often mechanically applies the fan-beam CT criterion of "180° plus fan angle" in pursuit of "data completeness" in reconstruction. This review argues that, under the single circular trajectory of three-dimensional cone-beam geometry, complete data are mathematically unattainable; moreover, blindly increasing sampling may exacerbate the trade-off among intraoperative image quality (Q), imaging time (T), and radiation dose (D). Against this background, this review reframes the evaluation of intraoperative CBCT around "data sufficiency" rather than "data completeness." This perspective moves beyond the excessive pursuit of absolute mathematical and analytic accuracy, and instead emphasizes task-specific minimum image-quality thresholds required for clinical decision-making. By synthesizing evidence from multiple clinical scenarios, this review suggests that approximation errors can be acceptable when clinical decision-making requirements are satisfied, thereby achieving a Q-T-D balance. △ Less

Submitted 8 July, 2026; originally announced July 2026.

Duet: Dual-Robot Understanding via Efficient Teaching

Authors: Yiqi Zhao, Ruohai Ge, Celina Shiyu Wang, Junjie Ye, Muchen Xu, Minhao Li, Sergey Zakharov, Basile Van Hoorick, Vitor Campagnolo Guizilini, Leonidas Guibas, Gaurav S. Sukhatme, Jyotirmoy V. Deshmukh, Yue Wang

Abstract: Dual-robot collaboration enables tasks that exceed the reach and payload of a single robot, such as collaboratively transporting objects across environments and executing coordinated handovers. Data acquisition is the primary bottleneck for training these systems. To this end, we introduce DUET, a dual-robot learning framework for mobile manipulation. For efficient data collection, we create a uni… ▽ More Dual-robot collaboration enables tasks that exceed the reach and payload of a single robot, such as collaboratively transporting objects across environments and executing coordinated handovers. Data acquisition is the primary bottleneck for training these systems. To this end, we introduce DUET, a dual-robot learning framework for mobile manipulation. For efficient data collection, we create a unified dual-embodiment synchronized VR-based teleoperation system for in-domain heterogeneous robot data collection. We further develop a complementary tracking pipeline that records human-human coordination and collaborative mobile manipulation priors. To allow efficient learning, we introduce an Action Chunking Transformer based architecture that first pretrains collaborative policies on efficient human-human demonstrations, before finetuning them on a minimal set of real-robot teleoperation trajectories. We develop a benchmark of four collaborative tasks to evaluate our framework using a Unitree G1 humanoid and a Dexmate Vega1 mobile manipulator. The results demonstrate that harnessing human priors not only yields superior task performance compared to baselines trained only on robot data, but also reduces the total human effort required for data collection. Our human data collection pipeline achieves 5.4x acceleration on average from teleoperation, but we perform equally or better than robot-only data trained policies across all tasks. Our project page is available at https://zhaoy37.github.io/Duet/. △ Less

Submitted 18 June, 2026; originally announced June 2026.

DeepSeek-V4: Towards Highly Efficient Million-Token Context Intelligence

Authors: DeepSeek-AI, Anyi Xu, Bangcai Lin, Bing Xue, Bingxuan Wang, Bingzheng Xu, Bochao Wu, Bowei Zhang, Chaofan Lin, Chen Dong, Chenchen Ling, Chengda Lu, Chenggang Zhao, Chengqi Deng, Chengyu Hou, Chenhao Xu, Chenze Shao, Chong Ruan, Conner Sun, Damai Dai, Daya Guo, Dejian Yang, Deli Chen, Donghao Li, Dongjie Ji , et al. (294 additional authors not shown)

Abstract: We present a preview version of DeepSeek-V4 series, including two strong Mixture-of-Experts (MoE) language models -- DeepSeek-V4-Pro with 1.6T parameters (49B activated) and DeepSeek-V4-Flash with 284B parameters (13B activated) -- both supporting a context length of one million tokens. DeepSeek-V4 series incorporate several key upgrades in architecture and optimization: (1) a hybrid attention arc… ▽ More We present a preview version of DeepSeek-V4 series, including two strong Mixture-of-Experts (MoE) language models -- DeepSeek-V4-Pro with 1.6T parameters (49B activated) and DeepSeek-V4-Flash with 284B parameters (13B activated) -- both supporting a context length of one million tokens. DeepSeek-V4 series incorporate several key upgrades in architecture and optimization: (1) a hybrid attention architecture that combines Compressed Sparse Attention (CSA) and Heavily Compressed Attention (HCA) to improve long-context efficiency; (2) Manifold-Constrained Hyper-Connections (mHC) that enhance conventional residual connections; (3) and the Muon optimizer for faster convergence and greater training stability. We pre-train both models on more than 32T diverse and high-quality tokens, followed by a comprehensive post-training pipeline that unlocks and further enhances their capabilities. DeepSeek-V4-Pro-Max, the maximum reasoning effort mode of DeepSeek-V4-Pro, redefines the state-of-the-art for open models, outperforming its predecessors in core tasks. Meanwhile, DeepSeek-V4 series are highly efficient in long-context scenarios. In the one-million-token context setting, DeepSeek-V4-Pro requires only 27% of single-token inference FLOPs and 10% of KV cache compared with DeepSeek-V3.2. This enables us to routinely support one-million-token contexts, thereby making long-horizon tasks and further test-time scaling more feasible. The model checkpoints are available at https://huggingface.co/collections/deepseek-ai/deepseek-v4. △ Less

Submitted 26 April, 2026; originally announced June 2026.

Fine-Tuning Dynamics of In-Context Factual Recall in Transformers

Authors: Ruomin Huang, Eshaan Nichani, Jason D. Lee, Rong Ge

Abstract: In-context learning \ -- performing tasks based on examples given in the prompt \ -- is an important capability that has emerged in large language models and has received significant attention in both theory and practice. Existing theoretical work often focuses on settings where the learning uses information purely from the prompt. However, many practical instances of in-context learning require t… ▽ More In-context learning \ -- performing tasks based on examples given in the prompt \ -- is an important capability that has emerged in large language models and has received significant attention in both theory and practice. Existing theoretical work often focuses on settings where the learning uses information purely from the prompt. However, many practical instances of in-context learning require the model to retrieve factual knowledge stored in the model's parameters, with the context serving to identify which knowledge is relevant. In this work, we study how in-context learning leverages factual knowledge recall. We formalize this behavior by introducing the \emph{in-context factual recall (IC-recall)} task, where a transformer is provided a context of (subject, answer) pairs generated from a hidden relation, along with a query subject, and must both infer this hidden relation and retrieve the corresponding answer. Factual knowledge is modeled by the transformer having access to a simple pre-constructed MLP associative memory storing (subject, relation, answer) triplets. We analyze the supervised fine-tuning dynamics of a one-layer transformer on IC-recall data and prove that the model successfully performs IC-recall by converging to a particular pairwise attention pattern. This fine-tuning stage requires a very small number of samples \ -- only polylogarithmic in the number of stored knowledge triplets. Experiments verify our theoretical predictions and show that the pairwise attention pattern emerges even when the MLP layer is pretrained instead of constructed. △ Less

Submitted 26 May, 2026; originally announced May 2026.

Safactory: A Scalable Agentic Infrastructure for Training Trustworthy Autonomous Intelligence

Authors: Xinquan Chen, Zhenyun Yin, Shan He, Bin Huang, Shanzhe Lei, Pengcheng Shi, Kun Cai, Bei Chen, Bangwei Liu, Zeyu Kang, Chao Huang, Yang Zhang, Wenjie Li, Ruijun Ge, Yajie Wang, Tianshun Fang, Tianyang Xu, Yiwen Cong, Meng Jin, Gaolei Li, Xuansheng Wu, Linhan Liu, Zijing He, An Li, Yan Teng , et al. (16 additional authors not shown)

Abstract: As large models evolve from conversational assistants into autonomous agents, challenges increasingly arise from long-horizon decision making, tool use, and real environment interaction. Existing agenticinfrastructure remain fragmented across evaluation, data management, and agent evolution, making it difficult to discover risks systematically and improve models in a continuous closed loop. In thi… ▽ More As large models evolve from conversational assistants into autonomous agents, challenges increasingly arise from long-horizon decision making, tool use, and real environment interaction. Existing agenticinfrastructure remain fragmented across evaluation, data management, and agent evolution, making it difficult to discover risks systematically and improve models in a continuous closed loop. In this report, we present \textbf{Safactory}, a scalable agent factory for trustworthy autonomous intelligence. Safactory integrates three tightly coupled platforms: a \textbf{Parallel Simulation Platform} for trajectory generation, a \textbf{Trustworthy Data Platform} for trajectory storage and experience extraction, and an \textbf{Autonomous Evolution Platform} for asynchronous reinforcement learning and on-policy distillation. As far as we know, Safactory is the first framework to propose a unified evolutionary pipeline for next-generation trustworthy autonomous intelligence. △ Less

Submitted 7 May, 2026; v1 submitted 7 May, 2026; originally announced May 2026.

Comments: 50 pages, 21 figures

RelativeFlow: Taming Medical Image Denoising Learning with Noisy Reference

Authors: Yuxin Liu, Yiqing Dong, Wenxue Yu, Zhan Wu, Rongjun Ge, Yang Chen, Yuting He

Abstract: Medical image denoising (MID) lacks absolutely clean images for supervision, leading to a noisy reference problem that fundamentally limits denoising performance. Existing simulated-supervised discriminative learning (SimSDL) and simulated-supervised generative learning (SimSGL) treat noisy references as clean targets, causing suboptimal convergence or reference-biased learning, while self-supervi… ▽ More Medical image denoising (MID) lacks absolutely clean images for supervision, leading to a noisy reference problem that fundamentally limits denoising performance. Existing simulated-supervised discriminative learning (SimSDL) and simulated-supervised generative learning (SimSGL) treat noisy references as clean targets, causing suboptimal convergence or reference-biased learning, while self-supervised learning (SSL) imposes restrictive noise assumptions that are seldom satisfied in realistic MID scenarios. We propose \textbf{RelativeFlow}, a flow matching framework that learns from heterogeneous noisy references and drives inputs from arbitrary quality levels toward a unified high-quality target. RelativeFlow reformulates flow matching by decomposing the absolute noise-to-clean mapping into relative noisier-to-noisy mappings, and realizes this formulation through two key components: 1) consistent transport (CoT), a displacement map that constrains relative flows to be components of and progressively compose a unified absolute flow, and 2) simulation-based velocity field (SVF), which constructs a learnable velocity field using modality-specific degradation operators to support different medical imaging modalities. Extensive experiments on Computed Tomography (CT) and Magnetic Resonance (MR) denoising demonstrate that RelativeFlow significantly outperforms existing methods, taming MID with noisy references. △ Less

Submitted 16 April, 2026; originally announced April 2026.

Comments: Accepted by CVPR 2026

AlphaEval: Evaluating Agents in Production

Authors: Pengrui Lu, Bingyu Xu, Wenjun Zhang, Shengjia Hua, Xuanjian Gao, Ranxiang Ge, Lyumanshan Ye, Linxuan Wu, Yiran Li, Junfei Fish Yu, Yibo Zhang, Ruixin Li, Manxiang Li, Xiao Han, Xiaocong Zhou, Guangyao Chi, Zisheng Chen, Kaishen Chen, Kun Wang, Qihua Xu, Fengyue Meng, Yuchen Ni, Jiajun Li, Jinxiu Liu, Danfeng Zhang , et al. (2 additional authors not shown)

Abstract: The rapid deployment of AI agents in commercial settings has outpaced the development of evaluation methodologies that reflect production realities. Existing benchmarks measure agent capabilities through retrospectively curated tasks with well-specified requirements and deterministic metrics -- conditions that diverge fundamentally from production environments where requirements contain implicit c… ▽ More The rapid deployment of AI agents in commercial settings has outpaced the development of evaluation methodologies that reflect production realities. Existing benchmarks measure agent capabilities through retrospectively curated tasks with well-specified requirements and deterministic metrics -- conditions that diverge fundamentally from production environments where requirements contain implicit constraints, inputs are heterogeneous multi-modal documents with information fragmented across sources, tasks demand undeclared domain expertise, outputs are long-horizon professional deliverables, and success is judged by domain experts whose standards evolve over time. We present AlphaEval, a production-grounded benchmark of 94 tasks sourced from seven companies deploying AI agents in their core business, spanning six O*NET (Occupational Information Network) domains. Unlike model-centric benchmarks, AlphaEval evaluates complete agent products -- Claude Code, Codex, etc. -- as commercial systems, capturing performance variations invisible to model-level evaluation. Our evaluation framework covers multiple paradigms (LLM-as-a-Judge, reference-driven metrics, formal verification, rubric-based assessment, automated UI testing, etc.), with individual domains composing multiple paradigms. Beyond the benchmark itself, we contribute a requirement-to-benchmark construction framework -- a systematic methodology that transforms authentic production requirements into executable evaluation tasks in minimal time. This framework standardizes the entire pipeline from requirement to evaluation, providing a reproducible, modular process that any organization can adopt to construct production-grounded benchmarks for their own domains. △ Less

Submitted 13 April, 2026; originally announced April 2026.

Learning-Augmented Algorithms for $k$-median via Online Learning

Authors: Anish Hebbar, Rong Ge, Amit Kumar, Debmalya Panigrahi

Abstract: The field of learning-augmented algorithms seeks to use ML techniques on past instances of a problem to inform an algorithm designed for a future instance. In this paper, we introduce a novel model for learning-augmented algorithms inspired by online learning. In this model, we are given a sequence of instances of a problem and the goal of the learning-augmented algorithm is to use prior instances… ▽ More The field of learning-augmented algorithms seeks to use ML techniques on past instances of a problem to inform an algorithm designed for a future instance. In this paper, we introduce a novel model for learning-augmented algorithms inspired by online learning. In this model, we are given a sequence of instances of a problem and the goal of the learning-augmented algorithm is to use prior instances to propose a solution to a future instance of the problem. The performance of the algorithm is measured by its average performance across all the instances, where the performance on a single instance is the ratio between the cost of the algorithm's solution and that of an optimal solution for that instance. We apply this framework to the classic $k$-median clustering problem, and give an efficient learning algorithm that can approximately match the average performance of the best fixed $k$-median solution in hindsight across all the instances. We also experimentally evaluate our algorithm and show that its empirical performance is close to optimal, and also that it automatically adapts the solution to a dynamically changing sequence. △ Less

Submitted 18 March, 2026; originally announced March 2026.

Comments: NeurIPS 2025

Internalizing Agency from Reflective Experience

Authors: Rui Ge, Yichao Fu, Yuyang Qian, Junda Su, Yiming Zhao, Peng Zhao, Hao Zhang

Abstract: Large language models are increasingly deployed as autonomous agents that must plan, act, and recover from mistakes through long-horizon interaction with environments that provide rich feedback. However, prevailing outcome-driven post-training methods (e.g., RL with verifiable rewards) primarily optimize final success signals, leaving rich environment feedback underutilized. Consequently, they oft… ▽ More Large language models are increasingly deployed as autonomous agents that must plan, act, and recover from mistakes through long-horizon interaction with environments that provide rich feedback. However, prevailing outcome-driven post-training methods (e.g., RL with verifiable rewards) primarily optimize final success signals, leaving rich environment feedback underutilized. Consequently, they often lead to distribution sharpening: the policy becomes better at reproducing a narrow set of already-successful behaviors, while failing to improve the feedback-grounded agency needed to expand problem-solving capacity (e.g., Pass@k) in long-horizon settings. To address this, we propose LEAFE (Learning Feedback-Grounded Agency from Reflective Experience), a framework that internalizes recovery agency from reflective experience. Specifically, during exploration, the agent summarizes environment feedback into actionable experience, backtracks to earlier decision points, and explores alternative branches with revised actions. We then distill these experience-guided corrections into the model through supervised fine-tuning, enabling the policy to recover more effectively in future interactions. Across a diverse set of interactive coding and agentic tasks under fixed interaction budgets, LEAFE consistently improves Pass@1 over the base model and achieves higher Pass@k than outcome-driven baselines (GRPO) and experience-based methods such as Early Experience, with gains of up to 14% on Pass@128. △ Less

Submitted 17 March, 2026; originally announced March 2026.

Comments: 17 pages, 5 figures; Submitted to ICML 2026

MRI Contrast Enhancement Kinetics World Model

Authors: Jindi Kong, Yuting He, Cong Xia, Rongjun Ge, Shuo Li

Abstract: Clinical MRI contrast acquisition suffers from inefficient information yield, which presents as a mismatch between the risky and costly acquisition protocol and the fixed and sparse acquisition sequence. Applying world models to simulate the contrast enhancement kinetics in the human body enables continuous contrast-free dynamics. However, the low temporal resolution in MRI acquisition restricts t… ▽ More Clinical MRI contrast acquisition suffers from inefficient information yield, which presents as a mismatch between the risky and costly acquisition protocol and the fixed and sparse acquisition sequence. Applying world models to simulate the contrast enhancement kinetics in the human body enables continuous contrast-free dynamics. However, the low temporal resolution in MRI acquisition restricts the training of world models, leading to a sparsely sampled dataset. Directly training a generative model to capture the kinetics leads to two limitations: (a) Due to the absence of data on missing time, the model tends to overfit to irrelevant features, leading to content distortion. (b) Due to the lack of continuous temporal supervision, the model fails to learn the continuous kinetics law over time, causing temporal discontinuities. For the first time, we propose MRI Contrast Enhancement Kinetics World model (MRI CEKWorld) with SpatioTemporal Consistency Learning (STCL). For (a), guided by the spatial law that patient-level structures remain consistent during enhancement, we propose Latent Alignment Learning (LAL) that constructs a patient-specific template to constrain contents to align with this template. For (b), guided by the temporal law that the kinetics follow a consistent smooth trend, we propose Latent Difference Learning (LDL) which extends the unobserved intervals by interpolation and constrains smooth variations in the latent space among interpolated sequences. Extensive experiments on two datasets show our MRI CEKWorld achieves better realistic contents and kinetics. Codes will be available at https://github.com/DD0922/MRI-Contrast-Enhancement-Kinetics-World-Model. △ Less

Submitted 22 February, 2026; originally announced February 2026.

Comments: Accepted by CVPR 2026

DGSAN: Dual-Graph Spatiotemporal Attention Network for Pulmonary Nodule Malignancy Prediction

Authors: Xiao Yu, Zhaojie Fang, Guanyu Zhou, Yin Shen, Huoling Luo, Ye Li, Ahmed Elazab, Xiang Wan, Ruiquan Ge, Changmiao Wang

Abstract: Lung cancer continues to be the leading cause of cancer-related deaths globally. Early detection and diagnosis of pulmonary nodules are essential for improving patient survival rates. Although previous research has integrated multimodal and multi-temporal information, outperforming single modality and single time point, the fusion methods are limited to inefficient vector concatenation and simple… ▽ More Lung cancer continues to be the leading cause of cancer-related deaths globally. Early detection and diagnosis of pulmonary nodules are essential for improving patient survival rates. Although previous research has integrated multimodal and multi-temporal information, outperforming single modality and single time point, the fusion methods are limited to inefficient vector concatenation and simple mutual attention, highlighting the need for more effective multimodal information fusion. To address these challenges, we introduce a Dual-Graph Spatiotemporal Attention Network, which leverages temporal variations and multimodal data to enhance the accuracy of predictions. Our methodology involves developing a Global-Local Feature Encoder to better capture the local, global, and fused characteristics of pulmonary nodules. Additionally, a Dual-Graph Construction method organizes multimodal features into inter-modal and intra-modal graphs. Furthermore, a Hierarchical Cross-Modal Graph Fusion Module is introduced to refine feature integration. We also compiled a novel multimodal dataset named the NLST-cmst dataset as a comprehensive source of support for related research. Our extensive experiments, conducted on both the NLST-cmst and curated CSTL-derived datasets, demonstrate that our DGSAN significantly outperforms state-of-the-art methods in classifying pulmonary nodules with exceptional computational efficiency. △ Less

Submitted 23 December, 2025; originally announced December 2025.

Insight Miner: A Time Series Analysis Dataset for Cross-Domain Alignment with Natural Language

Authors: Yunkai Zhang, Yawen Zhang, Ming Zheng, Kezhen Chen, Chongyang Gao, Ruian Ge, Siyuan Teng, Amine Jelloul, Jinmeng Rao, Xiaoyuan Guo, Chiang-Wei Fang, Zeyu Zheng, Jie Yang

Abstract: Time-series data is critical across many scientific and industrial domains, including environmental analysis, agriculture, transportation, and finance. However, mining insights from this data typically requires deep domain expertise, a process that is both time-consuming and labor-intensive. In this paper, we propose \textbf{Insight Miner}, a large-scale multimodal model (LMM) designed to generate… ▽ More Time-series data is critical across many scientific and industrial domains, including environmental analysis, agriculture, transportation, and finance. However, mining insights from this data typically requires deep domain expertise, a process that is both time-consuming and labor-intensive. In this paper, we propose \textbf{Insight Miner}, a large-scale multimodal model (LMM) designed to generate high-quality, comprehensive time-series descriptions enriched with domain-specific knowledge. To facilitate this, we introduce \textbf{TS-Insights}\footnote{Available at \href{https://huggingface.co/datasets/zhykoties/time-series-language-alignment}{https://huggingface.co/datasets/zhykoties/time-series-language-alignment}.}, the first general-domain dataset for time series and language alignment. TS-Insights contains 100k time-series windows sampled from 20 forecasting datasets. We construct this dataset using a novel \textbf{agentic workflow}, where we use statistical tools to extract features from raw time series before synthesizing them into coherent trend descriptions with GPT-4. Following instruction tuning on TS-Insights, Insight Miner outperforms state-of-the-art multimodal models, such as LLaVA \citep{liu2023llava} and GPT-4, in generating time-series descriptions and insights. Our findings suggest a promising direction for leveraging LMMs in time series analysis, and serve as a foundational step toward enabling LLMs to interpret time series as a native input modality. △ Less

Submitted 11 December, 2025; originally announced December 2025.

DINO-BOLDNet: A DINOv3-Guided Multi-Slice Attention Network for T1-to-BOLD Generation

Authors: Jianwei Wang, Qing Wang, Menglan Ruan, Rongjun Ge, Chunfeng Yang, Yang Chen, Chunming Xie

Abstract: Generating BOLD images from T1w images offers a promising solution for recovering missing BOLD information and enabling downstream tasks when BOLD images are corrupted or unavailable. Motivated by this, we propose DINO-BOLDNet, a DINOv3-guided multi-slice attention framework that integrates a frozen self-supervised DINOv3 encoder with a lightweight trainable decoder. The model uses DINOv3 to extra… ▽ More Generating BOLD images from T1w images offers a promising solution for recovering missing BOLD information and enabling downstream tasks when BOLD images are corrupted or unavailable. Motivated by this, we propose DINO-BOLDNet, a DINOv3-guided multi-slice attention framework that integrates a frozen self-supervised DINOv3 encoder with a lightweight trainable decoder. The model uses DINOv3 to extract within-slice structural representations, and a separate slice-attention module to fuse contextual information across neighboring slices. A multi-scale generation decoder then restores fine-grained functional contrast, while a DINO-based perceptual loss encourages structural and textural consistency between predictions and ground-truth BOLD in the transformer feature space. Experiments on a clinical dataset of 248 subjects show that DINO-BOLDNet surpasses a conditional GAN baseline in both PSNR and MS-SSIM. To our knowledge, this is the first framework capable of generating mean BOLD images directly from T1w images, highlighting the potential of self-supervised transformer guidance for structural-to-functional mapping. △ Less

Submitted 9 December, 2025; originally announced December 2025.

DeepSeek-V3.2: Pushing the Frontier of Open Large Language Models

Authors: DeepSeek-AI, Aixin Liu, Aoxue Mei, Bangcai Lin, Bing Xue, Bingxuan Wang, Bingzheng Xu, Bochao Wu, Bowei Zhang, Chaofan Lin, Chen Dong, Chengda Lu, Chenggang Zhao, Chengqi Deng, Chenhao Xu, Chong Ruan, Damai Dai, Daya Guo, Dejian Yang, Deli Chen, Erhang Li, Fangqi Zhou, Fangyun Lin, Fucong Dai, Guangbo Hao , et al. (239 additional authors not shown)

Abstract: We introduce DeepSeek-V3.2, a model that harmonizes high computational efficiency with superior reasoning and agent performance. The key technical breakthroughs of DeepSeek-V3.2 are as follows: (1) DeepSeek Sparse Attention (DSA): We introduce DSA, an efficient attention mechanism that substantially reduces computational complexity while preserving model performance in long-context scenarios. (2)… ▽ More We introduce DeepSeek-V3.2, a model that harmonizes high computational efficiency with superior reasoning and agent performance. The key technical breakthroughs of DeepSeek-V3.2 are as follows: (1) DeepSeek Sparse Attention (DSA): We introduce DSA, an efficient attention mechanism that substantially reduces computational complexity while preserving model performance in long-context scenarios. (2) Scalable Reinforcement Learning Framework: By implementing a robust reinforcement learning protocol and scaling post-training compute, DeepSeek-V3.2 performs comparably to GPT-5. Notably, our high-compute variant, DeepSeek-V3.2-Speciale, surpasses GPT-5 and exhibits reasoning proficiency on par with Gemini-3.0-Pro, achieving gold-medal performance in both the 2025 International Mathematical Olympiad (IMO) and the International Olympiad in Informatics (IOI). (3) Large-Scale Agentic Task Synthesis Pipeline: To integrate reasoning into tool-use scenarios, we developed a novel synthesis pipeline that systematically generates training data at scale. This methodology facilitates scalable agentic post-training, yielding substantial improvements in generalization and instruction-following robustness within complex, interactive environments. △ Less

Submitted 2 December, 2025; originally announced December 2025.

SUPERChem: A Multimodal Reasoning Benchmark in Chemistry

Authors: Zehua Zhao, Zhixian Huang, Junren Li, Siyu Lin, Junting Zhou, Fengqi Cao, Kun Zhou, Rui Ge, Tingting Long, Yuexiang Zhu, Yan Liu, Jie Zheng, Junnian Wei, Rong Zhu, Peng Zou, Wenyu Li, Zekai Cheng, Tian Ding, Yaxuan Wang, Yizhao Yan, Tingru Wei, Haowei Ming, Weijie Mao, Chen Sun, Yiming Liu , et al. (6 additional authors not shown)

Abstract: Current benchmarks for evaluating the chemical reasoning capabilities of Large Language Models (LLMs) are limited by oversimplified tasks, lack of process-level evaluation, and misalignment with expert-level chemistry skills. To address these issues, we introduce SUPERChem, a benchmark of 500 expert-curated reasoning-intensive chemistry problems, covering diverse subfields and provided in both mul… ▽ More Current benchmarks for evaluating the chemical reasoning capabilities of Large Language Models (LLMs) are limited by oversimplified tasks, lack of process-level evaluation, and misalignment with expert-level chemistry skills. To address these issues, we introduce SUPERChem, a benchmark of 500 expert-curated reasoning-intensive chemistry problems, covering diverse subfields and provided in both multimodal and text-only formats. Original content and an iterative curation pipeline eliminate flawed items and mitigate data contamination. Each problem is paired with an expert-authored solution path, enabling Reasoning Path Fidelity (RPF) scoring to evaluate reasoning quality beyond final-answer accuracy. Evaluations against a human baseline of 40.3% accuracy show that even the best-performing model, GPT-5 (High), reaches only 38.5%, followed closely by Gemini 2.5 Pro (37.9%) and DeepSeek-V3.1-Think (37.3%). SUPERChem elicits multi-step, multimodal reasoning, reveals model-dependent effects of visual information, and distinguishes high-fidelity reasoners from heuristic ones. By providing a challenging benchmark and a reliable evaluation framework, SUPERChem aims to facilitate the advancement of LLMs toward expert-level chemical intelligence. The dataset of the benchmark is available at https://huggingface.co/datasets/ZehuaZhao/SUPERChem. △ Less

Submitted 30 November, 2025; originally announced December 2025.

Comments: 35 pages, 11 figures, 5 tables

LungNoduleAgent: A Collaborative Multi-Agent System for Precision Diagnosis of Lung Nodules

Authors: Cheng Yang, Hui Jin, Xinlei Yu, Zhipeng Wang, Yaoqun Liu, Fenglei Fan, Dajiang Lei, Gangyong Jia, Changmiao Wang, Ruiquan Ge

Abstract: Diagnosing lung cancer typically involves physicians identifying lung nodules in Computed tomography (CT) scans and generating diagnostic reports based on their morphological features and medical expertise. Although advancements have been made in using multimodal large language models for analyzing lung CT scans, challenges remain in accurately describing nodule morphology and incorporating medica… ▽ More Diagnosing lung cancer typically involves physicians identifying lung nodules in Computed tomography (CT) scans and generating diagnostic reports based on their morphological features and medical expertise. Although advancements have been made in using multimodal large language models for analyzing lung CT scans, challenges remain in accurately describing nodule morphology and incorporating medical expertise. These limitations affect the reliability and effectiveness of these models in clinical settings. Collaborative multi-agent systems offer a promising strategy for achieving a balance between generality and precision in medical applications, yet their potential in pathology has not been thoroughly explored. To bridge these gaps, we introduce LungNoduleAgent, an innovative collaborative multi-agent system specifically designed for analyzing lung CT scans. LungNoduleAgent streamlines the diagnostic process into sequential components, improving precision in describing nodules and grading malignancy through three primary modules. The first module, the Nodule Spotter, coordinates clinical detection models to accurately identify nodules. The second module, the Radiologist, integrates localized image description techniques to produce comprehensive CT reports. Finally, the Doctor Agent System performs malignancy reasoning by using images and CT reports, supported by a pathology knowledge base and a multi-agent system framework. Extensive testing on two private datasets and the public LIDC-IDRI dataset indicates that LungNoduleAgent surpasses mainstream vision-language models, agent systems, and advanced expert models. These results highlight the importance of region-level semantic alignment and multi-agent collaboration in diagnosing nodules. LungNoduleAgent stands out as a promising foundational tool for supporting clinical analyses of lung nodules. △ Less

Submitted 25 November, 2025; originally announced November 2025.

Comments: Accepted by AAAI 2026

LEARN: Learning End-to-End Aerial Resource-Constrained Multi-Robot Navigation

Authors: Darren Chiu, Zhehui Huang, Ruohai Ge, Gaurav S. Sukhatme

Abstract: Nano-UAV teams offer great agility yet face severe navigation challenges due to constrained onboard sensing, communication, and computation. Existing approaches rely on high-resolution vision or compute-intensive planners, rendering them infeasible for these platforms. We introduce LEARN, a lightweight, two-stage safety-guided reinforcement learning (RL) framework for multi-UAV navigation in clutt… ▽ More Nano-UAV teams offer great agility yet face severe navigation challenges due to constrained onboard sensing, communication, and computation. Existing approaches rely on high-resolution vision or compute-intensive planners, rendering them infeasible for these platforms. We introduce LEARN, a lightweight, two-stage safety-guided reinforcement learning (RL) framework for multi-UAV navigation in cluttered spaces. Our system combines low-resolution Time-of-Flight (ToF) sensors and a simple motion planner with a compact, attention-based RL policy. In simulation, LEARN outperforms two state-of-the-art planners by $10\%$ while using substantially fewer resources. We demonstrate LEARN's viability on six Crazyflie quadrotors, achieving fully onboard flight in diverse indoor and outdoor environments at speeds up to $2.0 m/s$ and traversing $0.2 m$ gaps. △ Less

Submitted 21 November, 2025; originally announced November 2025.

Comments: 20 pages, 15 figures

WDT-MD: Wavelet Diffusion Transformers for Microaneurysm Detection in Fundus Images

Authors: Yifei Sun, Yuzhi He, Junhao Jia, Jinhong Wang, Ruiquan Ge, Changmiao Wang, Hongxia Xu

Abstract: Microaneurysms (MAs), the earliest pathognomonic signs of Diabetic Retinopathy (DR), present as sub-60 $μm$ lesions in fundus images with highly variable photometric and morphological characteristics, rendering manual screening not only labor-intensive but inherently error-prone. While diffusion-based anomaly detection has emerged as a promising approach for automated MA screening, its clinical ap… ▽ More Microaneurysms (MAs), the earliest pathognomonic signs of Diabetic Retinopathy (DR), present as sub-60 $μm$ lesions in fundus images with highly variable photometric and morphological characteristics, rendering manual screening not only labor-intensive but inherently error-prone. While diffusion-based anomaly detection has emerged as a promising approach for automated MA screening, its clinical application is hindered by three fundamental limitations. First, these models often fall prey to "identity mapping", where they inadvertently replicate the input image. Second, they struggle to distinguish MAs from other anomalies, leading to high false positives. Third, their suboptimal reconstruction of normal features hampers overall performance. To address these challenges, we propose a Wavelet Diffusion Transformer framework for MA Detection (WDT-MD), which features three key innovations: a noise-encoded image conditioning mechanism to avoid "identity mapping" by perturbing image conditions during training; pseudo-normal pattern synthesis via inpainting to introduce pixel-level supervision, enabling discrimination between MAs and other anomalies; and a wavelet diffusion Transformer architecture that combines the global modeling capability of diffusion Transformers with multi-scale wavelet analysis to enhance reconstruction of normal retinal features. Comprehensive experiments on the IDRiD and e-ophtha MA datasets demonstrate that WDT-MD outperforms state-of-the-art methods in both pixel-level and image-level MA detection. This advancement holds significant promise for improving early DR screening. △ Less

Submitted 12 December, 2025; v1 submitted 12 November, 2025; originally announced November 2025.

Comments: 9 pages, 6 figures, 8 tables, accepted by AAAI 2026

The Tool Decathlon: Benchmarking Language Agents for Diverse, Realistic, and Long-Horizon Task Execution

Authors: Junlong Li, Wenshuo Zhao, Jian Zhao, Weihao Zeng, Haoze Wu, Xiaochen Wang, Rui Ge, Yuxuan Cao, Yuzhen Huang, Wei Liu, Junteng Liu, Zhaochen Su, Yiyang Guo, Fan Zhou, Lueyang Zhang, Juan Michelini, Xingyao Wang, Xiang Yue, Shuyan Zhou, Graham Neubig, Junxian He

Abstract: Real-world language agents must handle complex, multi-step workflows across diverse Apps. For instance, an agent may manage emails by coordinating with calendars and file systems, or monitor a production database to detect anomalies and generate reports following an operating manual. However, existing language agent benchmarks often focus on narrow domains or simplified tasks that lack the diversi… ▽ More Real-world language agents must handle complex, multi-step workflows across diverse Apps. For instance, an agent may manage emails by coordinating with calendars and file systems, or monitor a production database to detect anomalies and generate reports following an operating manual. However, existing language agent benchmarks often focus on narrow domains or simplified tasks that lack the diversity, realism, and long-horizon complexity required to evaluate agents' real-world performance. To address this gap, we introduce the Tool Decathlon (dubbed as Toolathlon), a benchmark for language agents offering diverse Apps and tools, realistic environment setup, and reliable execution-based evaluation. Toolathlon spans 32 software applications and 604 tools, ranging from everyday platforms such as Google Calendar and Notion to professional ones like WooCommerce, Kubernetes, and BigQuery. Most of the tools are based on a high-quality set of Model Context Protocol (MCP) servers that we may have revised or implemented ourselves. Unlike prior works, which primarily ensure functional realism but offer limited environment state diversity, we provide realistic initial environment states from real software, such as Canvas courses with dozens of students or real financial spreadsheets. This benchmark includes 108 manually sourced or crafted tasks in total, requiring interacting with multiple Apps over around 20 turns on average to complete. Each task is strictly verifiable through dedicated evaluation scripts. Comprehensive evaluation of SOTA models highlights their significant shortcomings: the best-performing model, Claude-4.5-Sonnet, achieves only a 38.6% success rate with 20.2 tool calling turns on average, while the top open-weights model DeepSeek-V3.2-Exp reaches 20.1%. We expect Toolathlon to drive the development of more capable language agents for real-world, long-horizon task execution. △ Less

Submitted 26 February, 2026; v1 submitted 29 October, 2025; originally announced October 2025.

Comments: ICLR 2026, Website: https://toolathlon.xyz/

Poisson Flow Consistency Training

Authors: Anthony Zhang, Mahmut Gokmen, Dennis Hein, Rongjun Ge, Wenjun Xia, Ge Wang, Jin Chen

Abstract: The Poisson Flow Consistency Model (PFCM) is a consistency-style model based on the robust Poisson Flow Generative Model++ (PFGM++) which has achieved success in unconditional image generation and CT image denoising. Yet the PFCM can only be trained in distillation which limits the potential of the PFCM in many data modalities. The objective of this research was to create a method to train the PFC… ▽ More The Poisson Flow Consistency Model (PFCM) is a consistency-style model based on the robust Poisson Flow Generative Model++ (PFGM++) which has achieved success in unconditional image generation and CT image denoising. Yet the PFCM can only be trained in distillation which limits the potential of the PFCM in many data modalities. The objective of this research was to create a method to train the PFCM in isolation called Poisson Flow Consistency Training (PFCT). The perturbation kernel was leveraged to remove the pretrained PFGM++, and the sinusoidal discretization schedule and Beta noise distribution were introduced in order to facilitate adaptability and improve sample quality. The model was applied to the task of low dose computed tomography image denoising and improved the low dose image in terms of LPIPS and SSIM. It also displayed similar denoising effectiveness as models like the Consistency Model. PFCT is established as a valid method of training the PFCM from its effectiveness in denoising CT images, showing potential with competitive results to other generative models. Further study is needed in the precise optimization of PFCT and in its applicability to other generative modeling tasks. The framework of PFCT creates more flexibility for the ways in which a PFCM can be created and can be applied to the field of generative modeling. △ Less

Submitted 22 October, 2025; originally announced October 2025.

Comments: 5 pages, 3 figures, 1 table

MSC Class: 68T07 (Primary); 68T45 (Secondary)

Memorizing Long-tail Data Can Help Generalization Through Composition

Authors: Mo Zhou, Haoyang Ma, Rong Ge

Abstract: Deep learning has led researchers to rethink the relationship between memorization and generalization. In many settings, memorization does not hurt generalization due to implicit regularization and may help by memorizing long-tailed examples. In this paper, we consider the synergy between memorization and simple composition -- the ability to make correct prediction on a combination of long-tailed… ▽ More Deep learning has led researchers to rethink the relationship between memorization and generalization. In many settings, memorization does not hurt generalization due to implicit regularization and may help by memorizing long-tailed examples. In this paper, we consider the synergy between memorization and simple composition -- the ability to make correct prediction on a combination of long-tailed features. Theoretically, we show that for a linear setting, memorization together with composition can help the model make correct predictions on rare test examples that require a combination of long-tailed features, even if such combinations were never observed in the training data. Experiments on neural network architecture on simple data show that the theoretical insight extends beyond the linear setting, and we further observe that the composition capability of the model depends on its architecture. △ Less

Submitted 17 October, 2025; originally announced October 2025.

Comments: 30 pages

Hierarchical Reasoning Models: Perspectives and Misconceptions

Authors: Renee Ge, Qianli Liao, Tomaso Poggio

Abstract: Transformers have demonstrated remarkable performance in natural language processing and related domains, as they largely focus on sequential, autoregressive next-token prediction tasks. Yet, they struggle in logical reasoning, not necessarily because of a fundamental limitation of these models, but possibly due to the lack of exploration of more creative uses, such as latent space and recurrent r… ▽ More Transformers have demonstrated remarkable performance in natural language processing and related domains, as they largely focus on sequential, autoregressive next-token prediction tasks. Yet, they struggle in logical reasoning, not necessarily because of a fundamental limitation of these models, but possibly due to the lack of exploration of more creative uses, such as latent space and recurrent reasoning. An emerging exploration in this direction is the Hierarchical Reasoning Model (Wang et. al., 2025), which introduces a novel type of recurrent reasoning in the latent space of transformers, achieving remarkable performance on a wide range of 2D reasoning tasks. Despite the promising results, this line of models is still at an early stage and calls for in-depth investigation. In this work, we review this class of models, examine key design choices, test alternative variants and clarify common misconceptions. △ Less

Submitted 7 October, 2025; v1 submitted 30 September, 2025; originally announced October 2025.

Comments: Found errors in some results of v1. Removed them and changed conclusions

GraphMMP: A Graph Neural Network Model with Mutual Information and Global Fusion for Multimodal Medical Prognosis

Authors: Xuhao Shan, Ruiquan Ge, Jikui Liu, Linglong Wu, Chi Zhang, Siqi Liu, Wenjian Qin, Wenwen Min, Ahmed Elazab, Changmiao Wang

Abstract: In the field of multimodal medical data analysis, leveraging diverse types of data and understanding their hidden relationships continues to be a research focus. The main challenges lie in effectively modeling the complex interactions between heterogeneous data modalities with distinct characteristics while capturing both local and global dependencies across modalities. To address these challenges… ▽ More In the field of multimodal medical data analysis, leveraging diverse types of data and understanding their hidden relationships continues to be a research focus. The main challenges lie in effectively modeling the complex interactions between heterogeneous data modalities with distinct characteristics while capturing both local and global dependencies across modalities. To address these challenges, this paper presents a two-stage multimodal prognosis model, GraphMMP, which is based on graph neural networks. The proposed model constructs feature graphs using mutual information and features a global fusion module built on Mamba, which significantly boosts prognosis performance. Empirical results show that GraphMMP surpasses existing methods on datasets related to liver prognosis and the METABRIC study, demonstrating its effectiveness in multimodal medical prognosis tasks. △ Less

Submitted 24 August, 2025; originally announced August 2025.

Think as Cardiac Sonographers: Marrying SAM with Left Ventricular Indicators Measurements According to Clinical Guidelines

Authors: Tuo Liu, Qinghan Yang, Yu Zhang, Rongjun Ge, Yang Chen, Guangquan Zhou

Abstract: Left ventricular (LV) indicator measurements following clinical echocardiog-raphy guidelines are important for diagnosing cardiovascular disease. Alt-hough existing algorithms have explored automated LV quantification, they can struggle to capture generic visual representations due to the normally small training datasets. Therefore, it is necessary to introduce vision founda-tional models (VFM) wi… ▽ More Left ventricular (LV) indicator measurements following clinical echocardiog-raphy guidelines are important for diagnosing cardiovascular disease. Alt-hough existing algorithms have explored automated LV quantification, they can struggle to capture generic visual representations due to the normally small training datasets. Therefore, it is necessary to introduce vision founda-tional models (VFM) with abundant knowledge. However, VFMs represented by the segment anything model (SAM) are usually suitable for segmentation but incapable of identifying key anatomical points, which are critical in LV indicator measurements. In this paper, we propose a novel framework named AutoSAME, combining the powerful visual understanding of SAM with seg-mentation and landmark localization tasks simultaneously. Consequently, the framework mimics the operation of cardiac sonographers, achieving LV indi-cator measurements consistent with clinical guidelines. We further present fil-tered cross-branch attention (FCBA) in AutoSAME, which leverages relatively comprehensive features in the segmentation to enhance the heatmap regression (HR) of key points from the frequency domain perspective, optimizing the vis-ual representation learned by the latter. Moreover, we propose spatial-guided prompt alignment (SGPA) to automatically generate prompt embeddings guid-ed by spatial properties of LV, thereby improving the accuracy of dense pre-dictions by prior spatial knowledge. The extensive experiments on an echocar-diography dataset demonstrate the efficiency of each design and the superiori-ty of our AutoSAME in LV segmentation, landmark localization, and indicator measurements. The code will be available at https://github.com/QC-LIU-1997/AutoSAME. △ Less

Submitted 11 August, 2025; originally announced August 2025.

Small Lesions-aware Bidirectional Multimodal Multiscale Fusion Network for Lung Disease Classification

Authors: Jianxun Yu, Ruiquan Ge, Zhipeng Wang, Cheng Yang, Chenyu Lin, Xianjun Fu, Jikui Liu, Ahmed Elazab, Changmiao Wang

Abstract: The diagnosis of medical diseases faces challenges such as the misdiagnosis of small lesions. Deep learning, particularly multimodal approaches, has shown great potential in the field of medical disease diagnosis. However, the differences in dimensionality between medical imaging and electronic health record data present challenges for effective alignment and fusion. To address these issues, we pr… ▽ More The diagnosis of medical diseases faces challenges such as the misdiagnosis of small lesions. Deep learning, particularly multimodal approaches, has shown great potential in the field of medical disease diagnosis. However, the differences in dimensionality between medical imaging and electronic health record data present challenges for effective alignment and fusion. To address these issues, we propose the Multimodal Multiscale Cross-Attention Fusion Network (MMCAF-Net). This model employs a feature pyramid structure combined with an efficient 3D multi-scale convolutional attention module to extract lesion-specific features from 3D medical images. To further enhance multimodal data integration, MMCAF-Net incorporates a multi-scale cross-attention module, which resolves dimensional inconsistencies, enabling more effective feature fusion. We evaluated MMCAF-Net on the Lung-PET-CT-Dx dataset, and the results showed a significant improvement in diagnostic accuracy, surpassing current state-of-the-art methods. The code is available at https://github.com/yjx1234/MMCAF-Net △ Less

Submitted 6 August, 2025; originally announced August 2025.

GL-LCM: Global-Local Latent Consistency Models for Fast High-Resolution Bone Suppression in Chest X-Ray Images

Authors: Yifei Sun, Zhanghao Chen, Hao Zheng, Yuqing Lu, Lixin Duan, Fenglei Fan, Ahmed Elazab, Xiang Wan, Changmiao Wang, Ruiquan Ge

Abstract: Chest X-Ray (CXR) imaging for pulmonary diagnosis raises significant challenges, primarily because bone structures can obscure critical details necessary for accurate diagnosis. Recent advances in deep learning, particularly with diffusion models, offer significant promise for effectively minimizing the visibility of bone structures in CXR images, thereby improving clarity and diagnostic accuracy.… ▽ More Chest X-Ray (CXR) imaging for pulmonary diagnosis raises significant challenges, primarily because bone structures can obscure critical details necessary for accurate diagnosis. Recent advances in deep learning, particularly with diffusion models, offer significant promise for effectively minimizing the visibility of bone structures in CXR images, thereby improving clarity and diagnostic accuracy. Nevertheless, existing diffusion-based methods for bone suppression in CXR imaging struggle to balance the complete suppression of bones with preserving local texture details. Additionally, their high computational demand and extended processing time hinder their practical use in clinical settings. To address these limitations, we introduce a Global-Local Latent Consistency Model (GL-LCM) architecture. This model combines lung segmentation, dual-path sampling, and global-local fusion, enabling fast high-resolution bone suppression in CXR images. To tackle potential boundary artifacts and detail blurring in local-path sampling, we further propose Local-Enhanced Guidance, which addresses these issues without additional training. Comprehensive experiments on a self-collected dataset SZCH-X-Rays, and the public dataset JSRT, reveal that our GL-LCM delivers superior bone suppression and remarkable computational efficiency, significantly outperforming several competitive methods. Our code is available at https://github.com/diaoquesang/GL-LCM. △ Less

Submitted 5 August, 2025; originally announced August 2025.

Comments: 11 pages, 3 figures, accepted by MICCAI 2025

Extreme Cardiac MRI Analysis under Respiratory Motion: Results of the CMRxMotion Challenge

Authors: Kang Wang, Chen Qin, Zhang Shi, Haoran Wang, Xiwen Zhang, Chen Chen, Cheng Ouyang, Chengliang Dai, Yuanhan Mo, Chenchen Dai, Xutong Kuang, Ruizhe Li, Xin Chen, Xiuzheng Yue, Song Tian, Alejandro Mora-Rubio, Kumaradevan Punithakumar, Shizhan Gong, Qi Dou, Sina Amirrajab, Yasmina Al Khalil, Cian M. Scannell, Lexiaozi Fan, Huili Yang, Xiaowu Sun , et al. (24 additional authors not shown)

Abstract: Deep learning models have achieved state-of-the-art performance in automated Cardiac Magnetic Resonance (CMR) analysis. However, the efficacy of these models is highly dependent on the availability of high-quality, artifact-free images. In clinical practice, CMR acquisitions are frequently degraded by respiratory motion, yet the robustness of deep learning models against such artifacts remains an… ▽ More Deep learning models have achieved state-of-the-art performance in automated Cardiac Magnetic Resonance (CMR) analysis. However, the efficacy of these models is highly dependent on the availability of high-quality, artifact-free images. In clinical practice, CMR acquisitions are frequently degraded by respiratory motion, yet the robustness of deep learning models against such artifacts remains an underexplored problem. To promote research in this domain, we organized the MICCAI CMRxMotion challenge. We curated and publicly released a dataset of 320 CMR cine series from 40 healthy volunteers who performed specific breathing protocols to induce a controlled spectrum of motion artifacts. The challenge comprised two tasks: 1) automated image quality assessment to classify images based on motion severity, and 2) robust myocardial segmentation in the presence of motion artifacts. A total of 22 algorithms were submitted and evaluated on the two designated tasks. This paper presents a comprehensive overview of the challenge design and dataset, reports the evaluation results for the top-performing methods, and further investigates the impact of motion artifacts on five clinically relevant biomarkers. All resources and code are publicly available at: https://github.com/CMRxMotion △ Less

Submitted 25 July, 2025; originally announced July 2025.

SafeWork-R1: Coevolving Safety and Intelligence under the AI-45$^{\circ}$ Law

Authors: Shanghai AI Lab, :, Yicheng Bao, Guanxu Chen, Mingkang Chen, Yunhao Chen, Chiyu Chen, Lingjie Chen, Sirui Chen, Xinquan Chen, Jie Cheng, Yu Cheng, Dengke Deng, Yizhuo Ding, Dan Ding, Xiaoshan Ding, Yi Ding, Zhichen Dong, Lingxiao Du, Yuyu Fan, Xinshun Feng, Yanwei Fu, Yuxuan Gao, Ruijun Ge, Tianle Gu , et al. (93 additional authors not shown)

Abstract: We introduce SafeWork-R1, a cutting-edge multimodal reasoning model that demonstrates the coevolution of capabilities and safety. It is developed by our proposed SafeLadder framework, which incorporates large-scale, progressive, safety-oriented reinforcement learning post-training, supported by a suite of multi-principled verifiers. Unlike previous alignment methods such as RLHF that simply learn… ▽ More We introduce SafeWork-R1, a cutting-edge multimodal reasoning model that demonstrates the coevolution of capabilities and safety. It is developed by our proposed SafeLadder framework, which incorporates large-scale, progressive, safety-oriented reinforcement learning post-training, supported by a suite of multi-principled verifiers. Unlike previous alignment methods such as RLHF that simply learn human preferences, SafeLadder enables SafeWork-R1 to develop intrinsic safety reasoning and self-reflection abilities, giving rise to safety `aha' moments. Notably, SafeWork-R1 achieves an average improvement of $46.54\%$ over its base model Qwen2.5-VL-72B on safety-related benchmarks without compromising general capabilities, and delivers state-of-the-art safety performance compared to leading proprietary models such as GPT-4.1 and Claude Opus 4. To further bolster its reliability, we implement two distinct inference-time intervention methods and a deliberative search mechanism, enforcing step-level verification. Finally, we further develop SafeWork-R1-InternVL3-78B, SafeWork-R1-DeepSeek-70B, and SafeWork-R1-Qwen2.5VL-7B. All resulting models demonstrate that safety and capability can co-evolve synergistically, highlighting the generalizability of our framework in building robust, reliable, and trustworthy general-purpose AI. △ Less

Submitted 7 August, 2025; v1 submitted 24 July, 2025; originally announced July 2025.

Comments: 47 pages, 18 figures, authors are listed in alphabetical order by their last names; v3 modifies minor issues

GALE: Leveraging Heterogeneous Systems for Efficient Unstructured Mesh Data Analysis

Authors: Guoxi Liu, Thomas Randall, Rong Ge, Federico Iuricich

Abstract: Unstructured meshes present challenges in scientific data analysis due to irregular distribution and complex connectivity. Computing and storing connectivity information is a major bottleneck for visualization algorithms, affecting both time and memory performance. Recent task-parallel data structures address this by precomputing connectivity information at runtime while the analysis algorithm exe… ▽ More Unstructured meshes present challenges in scientific data analysis due to irregular distribution and complex connectivity. Computing and storing connectivity information is a major bottleneck for visualization algorithms, affecting both time and memory performance. Recent task-parallel data structures address this by precomputing connectivity information at runtime while the analysis algorithm executes, effectively hiding computation costs and improving performance. However, existing approaches are CPU-bound, forcing the data structure and analysis algorithm to compete for the same computational resources, limiting potential speedups. To overcome this limitation, we introduce a novel task-parallel approach optimized for heterogeneous CPU-GPU systems. Specifically, we offload the computation of mesh connectivity information to GPU threads, enabling CPU threads to focus on executing the visualization algorithm. Following this paradigm, we propose GALE (GPU-Aided Localized data structurE), the first open-source CUDA-based data structure designed for heterogeneous task parallelism. Experiments on two 20-core CPUs and an NVIDIA V100 GPU show that GALE achieves up to 2.7x speedup over state-of-the-art localized data structures while maintaining memory efficiency. △ Less

Submitted 30 July, 2025; v1 submitted 21 July, 2025; originally announced July 2025.

Comments: Accepted at IEEE VIS 2025

CRISP-SAM2: SAM2 with Cross-Modal Interaction and Semantic Prompting for Multi-Organ Segmentation

Authors: Xinlei Yu, Changmiao Wang, Hui Jin, Ahmed Elazab, Gangyong Jia, Xiang Wan, Changqing Zou, Ruiquan Ge

Abstract: Multi-organ medical segmentation is a crucial component of medical image processing, essential for doctors to make accurate diagnoses and develop effective treatment plans. Despite significant progress in this field, current multi-organ segmentation models often suffer from inaccurate details, dependence on geometric prompts and loss of spatial information. Addressing these challenges, we introduc… ▽ More Multi-organ medical segmentation is a crucial component of medical image processing, essential for doctors to make accurate diagnoses and develop effective treatment plans. Despite significant progress in this field, current multi-organ segmentation models often suffer from inaccurate details, dependence on geometric prompts and loss of spatial information. Addressing these challenges, we introduce a novel model named CRISP-SAM2 with CRoss-modal Interaction and Semantic Prompting based on SAM2. This model represents a promising approach to multi-organ medical segmentation guided by textual descriptions of organs. Our method begins by converting visual and textual inputs into cross-modal contextualized semantics using a progressive cross-attention interaction mechanism. These semantics are then injected into the image encoder to enhance the detailed understanding of visual information. To eliminate reliance on geometric prompts, we use a semantic prompting strategy, replacing the original prompt encoder to sharpen the perception of challenging targets. In addition, a similarity-sorting self-updating strategy for memory and a mask-refining process is applied to further adapt to medical imaging and enhance localized details. Comparative experiments conducted on seven public datasets indicate that CRISP-SAM2 outperforms existing models. Extensive analysis also demonstrates the effectiveness of our method, thereby confirming its superior performance, especially in addressing the limitations mentioned earlier. Our code is available at: https://github.com/YU-deep/CRISP_SAM2.git. △ Less

Submitted 13 July, 2025; v1 submitted 29 June, 2025; originally announced June 2025.

Comments: Accepted By ACMMM25

3D-Telepathy: Reconstructing 3D Objects from EEG Signals

Authors: Yuxiang Ge, Jionghao Cheng, Ruiquan Ge, Zhaojie Fang, Gangyong Jia, Xiang Wan, Nannan Li, Ahmed Elazab, Changmiao Wang

Abstract: Reconstructing 3D visual stimuli from Electroencephalography (EEG) data holds significant potential for applications in Brain-Computer Interfaces (BCIs) and aiding individuals with communication disorders. Traditionally, efforts have focused on converting brain activity into 2D images, neglecting the translation of EEG data into 3D objects. This limitation is noteworthy, as the human brain inheren… ▽ More Reconstructing 3D visual stimuli from Electroencephalography (EEG) data holds significant potential for applications in Brain-Computer Interfaces (BCIs) and aiding individuals with communication disorders. Traditionally, efforts have focused on converting brain activity into 2D images, neglecting the translation of EEG data into 3D objects. This limitation is noteworthy, as the human brain inherently processes three-dimensional spatial information regardless of whether observing 2D images or the real world. The neural activities captured by EEG contain rich spatial information that is inevitably lost when reconstructing only 2D images, thus limiting its practical applications in BCI. The transition from EEG data to 3D object reconstruction faces considerable obstacles. These include the presence of extensive noise within EEG signals and a scarcity of datasets that include both EEG and 3D information, which complicates the extraction process of 3D visual data. Addressing this challenging task, we propose an innovative EEG encoder architecture that integrates a dual self-attention mechanism. We use a hybrid training strategy to train the EEG Encoder, which includes cross-attention, contrastive learning, and self-supervised learning techniques. Additionally, by employing stable diffusion as a prior distribution and utilizing Variational Score Distillation to train a neural radiation field, we successfully generate 3D objects with similar content and structure from EEG data. △ Less

Submitted 26 June, 2025; originally announced June 2025.

Scaling Speculative Decoding with Lookahead Reasoning

Authors: Yichao Fu, Rui Ge, Zelei Shao, Zhijie Deng, Hao Zhang

Abstract: Reasoning models excel by generating long chain-of-thoughts, but decoding the resulting thousands of tokens is slow. Token-level speculative decoding (SD) helps, but its benefit is capped, because the chance that an entire $γ$-token guess is correct falls exponentially as $γ$ grows. This means allocating more compute for longer token drafts faces an algorithmic ceiling -- making the speedup modest… ▽ More Reasoning models excel by generating long chain-of-thoughts, but decoding the resulting thousands of tokens is slow. Token-level speculative decoding (SD) helps, but its benefit is capped, because the chance that an entire $γ$-token guess is correct falls exponentially as $γ$ grows. This means allocating more compute for longer token drafts faces an algorithmic ceiling -- making the speedup modest and hardware-agnostic. We raise this ceiling with Lookahead Reasoning, which exploits a second, step-level layer of parallelism. Our key insight is that reasoning models generate step-by-step, and each step needs only to be semantically correct, not exact token matching. In Lookahead Reasoning, a lightweight draft model proposes several future steps; the target model expands each proposal in one batched pass, and a verifier keeps semantically correct steps while letting the target regenerate any that fail. Token-level SD still operates within each reasoning step, so the two layers of parallelism multiply. We show Lookahead Reasoning lifts the peak speedup of SD both theoretically and empirically. Across GSM8K, AIME, and other benchmarks, Lookahead Reasoning improves the speedup of SD from 1.4x to 2.1x while preserving answer quality, and its speedup scales better with additional GPU throughput. Our code is available at https://github.com/hao-ai-lab/LookaheadReasoning △ Less

Submitted 24 June, 2025; originally announced June 2025.

Dataset Properties Shape the Success of Neuroimaging-Based Patient Stratification: A Benchmarking Analysis Across Clustering Algorithms

Authors: Yuetong Yu, Ruiyang Ge, Ilker Hacihaliloglu, Alexander Rauscher, Roger Tam, Sophia Frangou

Abstract: Background: Data driven stratification of patients into biologically informed subtypes holds promise for precision neuropsychiatry, yet neuroimaging-based clustering methods often fail to generalize across cohorts. While algorithmic innovations have focused on model complexity, the role of underlying dataset characteristics remains underexplored. We hypothesized that cluster separation, size imbal… ▽ More Background: Data driven stratification of patients into biologically informed subtypes holds promise for precision neuropsychiatry, yet neuroimaging-based clustering methods often fail to generalize across cohorts. While algorithmic innovations have focused on model complexity, the role of underlying dataset characteristics remains underexplored. We hypothesized that cluster separation, size imbalance, noise, and the direction and magnitude of disease-related effects in the input data critically determine both within-algorithm accuracy and reproducibility. Methods: We evaluated 4 widely used stratification algorithms, HYDRA, SuStaIn, SmileGAN, and SurrealGAN, on a suite of synthetic brain-morphometry cohorts derived from the Human Connectome Project Young Adult dataset. Three global transformation patterns were applied to 600 pseudo-patients against 508 controls, followed by 4 within-dataset variations varying cluster count (k=2-6), overlap, and effect magnitude. Algorithm performance was quantified by accuracy in recovering the known ground-truth clusters. Results: Across 122 synthetic scenarios, data complexity consistently outweighed algorithm choice in predicting stratification success. Well-separated clusters yielded high accuracy for all methods, whereas overlapping, unequal-sized, or subtle effects reduced accuracy by up to 50%. SuStaIn could not scale beyond 17 features, HYDRA's accuracy varied unpredictably with data heterogeneity. SmileGAN and SurrealGAN maintained robust pattern detection but did not assign discrete cluster labels to individuals. Conclusions: The study results demonstrate the impact of statistical properties of input data across algorithms and highlight the need for using realistic dataset distributions when new algorithms are being developed and suggest greater focus on data-centric strategies that actively shape and standardize the input distributions. △ Less

Submitted 10 June, 2025; v1 submitted 15 March, 2025; originally announced March 2025.

MAS-GPT: Training LLMs to Build LLM-based Multi-Agent Systems

Authors: Rui Ye, Shuo Tang, Rui Ge, Yaxin Du, Zhenfei Yin, Siheng Chen, Jing Shao

Abstract: LLM-based multi-agent systems (MAS) have shown significant potential in tackling diverse tasks. However, to design effective MAS, existing approaches heavily rely on manual configurations or multiple calls of advanced LLMs, resulting in inadaptability and high inference costs. In this paper, we simplify the process of building an MAS by reframing it as a generative language task, where the input i… ▽ More LLM-based multi-agent systems (MAS) have shown significant potential in tackling diverse tasks. However, to design effective MAS, existing approaches heavily rely on manual configurations or multiple calls of advanced LLMs, resulting in inadaptability and high inference costs. In this paper, we simplify the process of building an MAS by reframing it as a generative language task, where the input is a user query and the output is a corresponding MAS. To address this novel task, we unify the representation of MAS as executable code and propose a consistency-oriented data construction pipeline to create a high-quality dataset comprising coherent and consistent query-MAS pairs. Using this dataset, we train MAS-GPT, an open-source medium-sized LLM that is capable of generating query-adaptive MAS within a single LLM inference. The generated MAS can be seamlessly applied to process user queries and deliver high-quality responses. Extensive experiments on 9 benchmarks and 5 LLMs show that the proposed MAS-GPT consistently outperforms 10+ baseline MAS methods on diverse settings, indicating MAS-GPT's high effectiveness, efficiency and strong generalization ability. Code will be available at https://github.com/rui-ye/MAS-GPT. △ Less

Submitted 5 March, 2025; originally announced March 2025.

Comments: 26 pages, 7 figures

Homeomorphism Prior for False Positive and Negative Problem in Medical Image Dense Contrastive Representation Learning

Authors: Yuting He, Boyu Wang, Rongjun Ge, Yang Chen, Guanyu Yang, Shuo Li

Abstract: Dense contrastive representation learning (DCRL) has greatly improved the learning efficiency for image-dense prediction tasks, showing its great potential to reduce the large costs of medical image collection and dense annotation. However, the properties of medical images make unreliable correspondence discovery, bringing an open problem of large-scale false positive and negative (FP&N) pairs in… ▽ More Dense contrastive representation learning (DCRL) has greatly improved the learning efficiency for image-dense prediction tasks, showing its great potential to reduce the large costs of medical image collection and dense annotation. However, the properties of medical images make unreliable correspondence discovery, bringing an open problem of large-scale false positive and negative (FP&N) pairs in DCRL. In this paper, we propose GEoMetric vIsual deNse sImilarity (GEMINI) learning which embeds the homeomorphism prior to DCRL and enables a reliable correspondence discovery for effective dense contrast. We propose a deformable homeomorphism learning (DHL) which models the homeomorphism of medical images and learns to estimate a deformable mapping to predict the pixels' correspondence under topological preservation. It effectively reduces the searching space of pairing and drives an implicit and soft learning of negative pairs via a gradient. We also propose a geometric semantic similarity (GSS) which extracts semantic information in features to measure the alignment degree for the correspondence learning. It will promote the learning efficiency and performance of deformation, constructing positive pairs reliably. We implement two practical variants on two typical representation learning tasks in our experiments. Our promising results on seven datasets which outperform the existing methods show our great superiority. We will release our code on a companion link: https://github.com/YutingHe-list/GEMINI. △ Less

Submitted 7 February, 2025; originally announced February 2025.

Comments: Accepted by T-PAMI 2025

Gaze-Assisted Human-Centric Domain Adaptation for Cardiac Ultrasound Image Segmentation

Authors: Ruiyi Li, Yuting He, Rongjun Ge, Chong Wang, Daoqiang Zhang, Yang Chen, Shuo Li

Abstract: Domain adaptation (DA) for cardiac ultrasound image segmentation is clinically significant and valuable. However, previous domain adaptation methods are prone to be affected by the incomplete pseudo-label and low-quality target to source images. Human-centric domain adaptation has great advantages of human cognitive guidance to help model adapt to target domain and reduce reliance on labels. Docto… ▽ More Domain adaptation (DA) for cardiac ultrasound image segmentation is clinically significant and valuable. However, previous domain adaptation methods are prone to be affected by the incomplete pseudo-label and low-quality target to source images. Human-centric domain adaptation has great advantages of human cognitive guidance to help model adapt to target domain and reduce reliance on labels. Doctor gaze trajectories contains a large amount of cross-domain human guidance. To leverage gaze information and human cognition for guiding domain adaptation, we propose gaze-assisted human-centric domain adaptation (GAHCDA), which reliably guides the domain adaptation of cardiac ultrasound images. GAHCDA includes following modules: (1) Gaze Augment Alignment (GAA): GAA enables the model to obtain human cognition general features to recognize segmentation target in different domain of cardiac ultrasound images like humans. (2) Gaze Balance Loss (GBL): GBL fused gaze heatmap with outputs which makes the segmentation result structurally closer to the target domain. The experimental results illustrate that our proposed framework is able to segment cardiac ultrasound images more effectively in the target domain than GAN-based methods and other self-train based methods, showing great potential in clinical application. △ Less

Submitted 6 February, 2025; originally announced February 2025.

TMI-CLNet: Triple-Modal Interaction Network for Chronic Liver Disease Prognosis From Imaging, Clinical, and Radiomic Data Fusion

Authors: Linglong Wu, Xuhao Shan, Ruiquan Ge, Ruoyu Liang, Chi Zhang, Yonghong Li, Ahmed Elazab, Huoling Luo, Yunbi Liu, Changmiao Wang

Abstract: Chronic liver disease represents a significant health challenge worldwide and accurate prognostic evaluations are essential for personalized treatment plans. Recent evidence suggests that integrating multimodal data, such as computed tomography imaging, radiomic features, and clinical information, can provide more comprehensive prognostic information. However, modalities have an inherent heterogen… ▽ More Chronic liver disease represents a significant health challenge worldwide and accurate prognostic evaluations are essential for personalized treatment plans. Recent evidence suggests that integrating multimodal data, such as computed tomography imaging, radiomic features, and clinical information, can provide more comprehensive prognostic information. However, modalities have an inherent heterogeneity, and incorporating additional modalities may exacerbate the challenges of heterogeneous data fusion. Moreover, existing multimodal fusion methods often struggle to adapt to richer medical modalities, making it difficult to capture inter-modal relationships. To overcome these limitations, We present the Triple-Modal Interaction Chronic Liver Network (TMI-CLNet). Specifically, we develop an Intra-Modality Aggregation module and a Triple-Modal Cross-Attention Fusion module, which are designed to eliminate intra-modality redundancy and extract cross-modal information, respectively. Furthermore, we design a Triple-Modal Feature Fusion loss function to align feature representations across modalities. Extensive experiments on the liver prognosis dataset demonstrate that our approach significantly outperforms existing state-of-the-art unimodal models and other multi-modal techniques. Our code is available at https://github.com/Mysterwll/liver.git. △ Less

Submitted 2 February, 2025; originally announced February 2025.

Comments: 6 pages, 3 figures, accepted by IEEE ISBI 2025

DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning

Authors: DeepSeek-AI, Daya Guo, Dejian Yang, Haowei Zhang, Junxiao Song, Peiyi Wang, Qihao Zhu, Runxin Xu, Ruoyu Zhang, Shirong Ma, Xiao Bi, Xiaokang Zhang, Xingkai Yu, Yu Wu, Z. F. Wu, Zhibin Gou, Zhihong Shao, Zhuoshu Li, Ziyi Gao, Aixin Liu, Bing Xue, Bingxuan Wang, Bochao Wu, Bei Feng, Chengda Lu , et al. (175 additional authors not shown)

Abstract: General reasoning represents a long-standing and formidable challenge in artificial intelligence. Recent breakthroughs, exemplified by large language models (LLMs) and chain-of-thought prompting, have achieved considerable success on foundational reasoning tasks. However, this success is heavily contingent upon extensive human-annotated demonstrations, and models' capabilities are still insufficie… ▽ More General reasoning represents a long-standing and formidable challenge in artificial intelligence. Recent breakthroughs, exemplified by large language models (LLMs) and chain-of-thought prompting, have achieved considerable success on foundational reasoning tasks. However, this success is heavily contingent upon extensive human-annotated demonstrations, and models' capabilities are still insufficient for more complex problems. Here we show that the reasoning abilities of LLMs can be incentivized through pure reinforcement learning (RL), obviating the need for human-labeled reasoning trajectories. The proposed RL framework facilitates the emergent development of advanced reasoning patterns, such as self-reflection, verification, and dynamic strategy adaptation. Consequently, the trained model achieves superior performance on verifiable tasks such as mathematics, coding competitions, and STEM fields, surpassing its counterparts trained via conventional supervised learning on human demonstrations. Moreover, the emergent reasoning patterns exhibited by these large-scale models can be systematically harnessed to guide and enhance the reasoning capabilities of smaller models. △ Less

Submitted 3 January, 2026; v1 submitted 22 January, 2025; originally announced January 2025.

Journal ref: Nature volume 645, pages 633-638 (2025)

ITCFN: Incomplete Triple-Modal Co-Attention Fusion Network for Mild Cognitive Impairment Conversion Prediction

Authors: Xiangyang Hu, Xiangyu Shen, Yifei Sun, Xuhao Shan, Wenwen Min, Liyilei Su, Xiaomao Fan, Ahmed Elazab, Ruiquan Ge, Changmiao Wang, Xiaopeng Fan

Abstract: Alzheimer's disease (AD) is a common neurodegenerative disease among the elderly. Early prediction and timely intervention of its prodromal stage, mild cognitive impairment (MCI), can decrease the risk of advancing to AD. Combining information from various modalities can significantly improve predictive accuracy. However, challenges such as missing data and heterogeneity across modalities complica… ▽ More Alzheimer's disease (AD) is a common neurodegenerative disease among the elderly. Early prediction and timely intervention of its prodromal stage, mild cognitive impairment (MCI), can decrease the risk of advancing to AD. Combining information from various modalities can significantly improve predictive accuracy. However, challenges such as missing data and heterogeneity across modalities complicate multimodal learning methods as adding more modalities can worsen these issues. Current multimodal fusion techniques often fail to adapt to the complexity of medical data, hindering the ability to identify relationships between modalities. To address these challenges, we propose an innovative multimodal approach for predicting MCI conversion, focusing specifically on the issues of missing positron emission tomography (PET) data and integrating diverse medical information. The proposed incomplete triple-modal MCI conversion prediction network is tailored for this purpose. Through the missing modal generation module, we synthesize the missing PET data from the magnetic resonance imaging and extract features using specifically designed encoders. We also develop a channel aggregation module and a triple-modal co-attention fusion module to reduce feature redundancy and achieve effective multimodal data fusion. Furthermore, we design a loss function to handle missing modality issues and align cross-modal features. These components collectively harness multimodal data to boost network performance. Experimental results on the ADNI1 and ADNI2 datasets show that our method significantly surpasses existing unimodal and other multimodal models. Our code is available at https://github.com/justinhxy/ITFC. △ Less

Submitted 20 January, 2025; originally announced January 2025.

Comments: 5 pages, 1 figure, accepted by IEEE ISBI 2025

DeepSeek-V3 Technical Report

Authors: DeepSeek-AI, Aixin Liu, Bei Feng, Bing Xue, Bingxuan Wang, Bochao Wu, Chengda Lu, Chenggang Zhao, Chengqi Deng, Chenyu Zhang, Chong Ruan, Damai Dai, Daya Guo, Dejian Yang, Deli Chen, Dongjie Ji, Erhang Li, Fangyun Lin, Fucong Dai, Fuli Luo, Guangbo Hao, Guanting Chen, Guowei Li, H. Zhang, Han Bao , et al. (175 additional authors not shown)

Abstract: We present DeepSeek-V3, a strong Mixture-of-Experts (MoE) language model with 671B total parameters with 37B activated for each token. To achieve efficient inference and cost-effective training, DeepSeek-V3 adopts Multi-head Latent Attention (MLA) and DeepSeekMoE architectures, which were thoroughly validated in DeepSeek-V2. Furthermore, DeepSeek-V3 pioneers an auxiliary-loss-free strategy for loa… ▽ More We present DeepSeek-V3, a strong Mixture-of-Experts (MoE) language model with 671B total parameters with 37B activated for each token. To achieve efficient inference and cost-effective training, DeepSeek-V3 adopts Multi-head Latent Attention (MLA) and DeepSeekMoE architectures, which were thoroughly validated in DeepSeek-V2. Furthermore, DeepSeek-V3 pioneers an auxiliary-loss-free strategy for load balancing and sets a multi-token prediction training objective for stronger performance. We pre-train DeepSeek-V3 on 14.8 trillion diverse and high-quality tokens, followed by Supervised Fine-Tuning and Reinforcement Learning stages to fully harness its capabilities. Comprehensive evaluations reveal that DeepSeek-V3 outperforms other open-source models and achieves performance comparable to leading closed-source models. Despite its excellent performance, DeepSeek-V3 requires only 2.788M H800 GPU hours for its full training. In addition, its training process is remarkably stable. Throughout the entire training process, we did not experience any irrecoverable loss spikes or perform any rollbacks. The model checkpoints are available at https://github.com/deepseek-ai/DeepSeek-V3. △ Less

Submitted 18 February, 2025; v1 submitted 26 December, 2024; originally announced December 2024.

BS-LDM: Effective Bone Suppression in High-Resolution Chest X-Ray Images with Conditional Latent Diffusion Models

Authors: Yifei Sun, Zhanghao Chen, Hao Zheng, Wenming Deng, Jin Liu, Wenwen Min, Ahmed Elazab, Xiang Wan, Changmiao Wang, Ruiquan Ge

Abstract: Lung diseases represent a significant global health challenge, with Chest X-Ray (CXR) being a key diagnostic tool due to its accessibility and affordability. Nonetheless, the detection of pulmonary lesions is often hindered by overlapping bone structures in CXR images, leading to potential misdiagnoses. To address this issue, we develop an end-to-end framework called BS-LDM, designed to effectivel… ▽ More Lung diseases represent a significant global health challenge, with Chest X-Ray (CXR) being a key diagnostic tool due to its accessibility and affordability. Nonetheless, the detection of pulmonary lesions is often hindered by overlapping bone structures in CXR images, leading to potential misdiagnoses. To address this issue, we develop an end-to-end framework called BS-LDM, designed to effectively suppress bone in high-resolution CXR images. This framework is based on conditional latent diffusion models and incorporates a multi-level hybrid loss-constrained vector-quantized generative adversarial network which is crafted for perceptual compression, ensuring the preservation of details. To further enhance the framework's performance, we utilize offset noise in the forward process, and a temporal adaptive thresholding strategy in the reverse process. These additions help minimize discrepancies in generating low-frequency information of soft tissue images. Additionally, we have compiled a high-quality bone suppression dataset named SZCH-X-Rays. This dataset includes 818 pairs of high-resolution CXR and soft tissue images collected from our partner hospital. Moreover, we processed 241 data pairs from the JSRT dataset into negative images, which are more commonly used in clinical practice. Our comprehensive experiments and downstream evaluations reveal that BS-LDM excels in bone suppression, underscoring its clinical value. Our code is available at https://github.com/diaoquesang/BS-LDM. △ Less

Submitted 6 July, 2025; v1 submitted 20 December, 2024; originally announced December 2024.

Comments: 12 pages, 8 figures, accepted by IEEE Journal of Biomedical and Health Informatics (JBHI) on July 4, 2025

ICH-SCNet: Intracerebral Hemorrhage Segmentation and Prognosis Classification Network Using CLIP-guided SAM mechanism

Authors: Xinlei Yu, Ahmed Elazab, Ruiquan Ge, Hui Jin, Xinchen Jiang, Gangyong Jia, Qing Wu, Qinglei Shi, Changmiao Wang

Abstract: Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke and is characterized by a high incidence of disability. Accurate segmentation of the ICH region and prognosis prediction are critically important for developing and refining treatment plans for post-ICH patients. However, existing approaches address these two tasks independently and predominantly focus on imaging data alone, thereb… ▽ More Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke and is characterized by a high incidence of disability. Accurate segmentation of the ICH region and prognosis prediction are critically important for developing and refining treatment plans for post-ICH patients. However, existing approaches address these two tasks independently and predominantly focus on imaging data alone, thereby neglecting the intrinsic correlation between the tasks and modalities. This paper introduces a multi-task network, ICH-SCNet, designed for both ICH segmentation and prognosis classification. Specifically, we integrate a SAM-CLIP cross-modal interaction mechanism that combines medical text and segmentation auxiliary information with neuroimaging data to enhance cross-modal feature recognition. Additionally, we develop an effective feature fusion module and a multi-task loss function to improve performance further. Extensive experiments on an ICH dataset reveal that our approach surpasses other state-of-the-art methods. It excels in the overall performance of classification tasks and outperforms competing models in all segmentation task metrics. △ Less

Submitted 7 November, 2024; originally announced November 2024.

Comments: 6 pages, 2 figures, 3 tables, published to BIBM 2024

Imaging foundation model for universal enhancement of non-ideal measurement CT

Authors: Rongjun Ge, Yuxin Liu, Zhan Wu, Shangwen Yang, Yuan Gao, Chenyu You, Ge Wang, Shuo Li, Yuting He, Yang Chen

Abstract: Non-ideal measurement computed tomography (NICT) employs suboptimal imaging protocols to expand CT applications. However, the resulting trade-offs degrade image quality, limiting clinical acceptability. Although deep learning methods have been used to enhance NICT images, their reliance on large training datasets and limited generalizability across diverse settings hinder practical use. We propose… ▽ More Non-ideal measurement computed tomography (NICT) employs suboptimal imaging protocols to expand CT applications. However, the resulting trade-offs degrade image quality, limiting clinical acceptability. Although deep learning methods have been used to enhance NICT images, their reliance on large training datasets and limited generalizability across diverse settings hinder practical use. We propose the multi-scale integrated Transformer AMPlifier (TAMP), the first imaging foundation model for universal NICT enhancement. Pre-trained on 10.8 million physics-driven simulated NICT images, TAMP generalizes effectively across various NICT settings, defect degrees, and body regions. Moreover, a parameter-efficient fine-tuning strategy enables TAMP to adapt to specific clinical scenarios using only few slices. Extensive experiments, including radiologists and real-world validations, demonstrate that TAMP consistently improves image quality and clinical acceptability, underscoring its significant potential to advance CT imaging and broaden NICT applications in clinical practice. △ Less

Submitted 22 March, 2026; v1 submitted 2 October, 2024; originally announced October 2024.

Comments: This paper has been accepted by Nature Communications

Leveraging Unstructured Text Data for Federated Instruction Tuning of Large Language Models

Authors: Rui Ye, Rui Ge, Yuchi Fengting, Jingyi Chai, Yanfeng Wang, Siheng Chen

Abstract: Federated instruction tuning enables multiple clients to collaboratively fine-tune a shared large language model (LLM) that can follow humans' instructions without directly sharing raw data. However, existing literature impractically requires that all the clients readily hold instruction-tuning data (i.e., structured instruction-response pairs), which necessitates massive human annotations since c… ▽ More Federated instruction tuning enables multiple clients to collaboratively fine-tune a shared large language model (LLM) that can follow humans' instructions without directly sharing raw data. However, existing literature impractically requires that all the clients readily hold instruction-tuning data (i.e., structured instruction-response pairs), which necessitates massive human annotations since clients' data is usually unstructured text instead. Addressing this, we propose a novel and flexible framework FedIT-U2S, which can automatically transform unstructured corpus into structured data for federated instruction tuning. FedIT-U2S consists two key steps: (1) few-shot instruction-tuning data generation, where each unstructured data piece together with several examples is combined to prompt an LLM in generating an instruction-response pair. To further enhance the flexibility, a retrieval-based example selection technique is proposed, where the examples are automatically selected based on the relatedness between the client's data piece and example pool, bypassing the need of determining examples in advance. (2) A typical federated instruction tuning process based on the generated data. Overall, FedIT-U2S can be applied to diverse scenarios as long as the client holds valuable text corpus, broadening the application scope of federated instruction tuning. We conduct a series of experiments on three domains (medicine, knowledge, and math), showing that our proposed FedIT-U2S can consistently and significantly brings improvement over the base LLM. △ Less

Submitted 11 September, 2024; originally announced September 2024.

Comments: 11 pages, work in progress

LPUWF-LDM: Enhanced Latent Diffusion Model for Precise Late-phase UWF-FA Generation on Limited Dataset

Authors: Zhaojie Fang, Xiao Yu, Guanyu Zhou, Ke Zhuang, Yifei Chen, Ruiquan Ge, Changmiao Wang, Gangyong Jia, Qing Wu, Juan Ye, Maimaiti Nuliqiman, Peifang Xu, Ahmed Elazab

Abstract: Ultra-Wide-Field Fluorescein Angiography (UWF-FA) enables precise identification of ocular diseases using sodium fluorescein, which can be potentially harmful. Existing research has developed methods to generate UWF-FA from Ultra-Wide-Field Scanning Laser Ophthalmoscopy (UWF-SLO) to reduce the adverse reactions associated with injections. However, these methods have been less effective in producin… ▽ More Ultra-Wide-Field Fluorescein Angiography (UWF-FA) enables precise identification of ocular diseases using sodium fluorescein, which can be potentially harmful. Existing research has developed methods to generate UWF-FA from Ultra-Wide-Field Scanning Laser Ophthalmoscopy (UWF-SLO) to reduce the adverse reactions associated with injections. However, these methods have been less effective in producing high-quality late-phase UWF-FA, particularly in lesion areas and fine details. Two primary challenges hinder the generation of high-quality late-phase UWF-FA: the scarcity of paired UWF-SLO and early/late-phase UWF-FA datasets, and the need for realistic generation at lesion sites and potential blood leakage regions. This study introduces an improved latent diffusion model framework to generate high-quality late-phase UWF-FA from limited paired UWF images. To address the challenges as mentioned earlier, our approach employs a module utilizing Cross-temporal Regional Difference Loss, which encourages the model to focus on the differences between early and late phases. Additionally, we introduce a low-frequency enhanced noise strategy in the diffusion forward process to improve the realism of medical images. To further enhance the mapping capability of the variational autoencoder module, especially with limited datasets, we implement a Gated Convolutional Encoder to extract additional information from conditional images. Our Latent Diffusion Model for Ultra-Wide-Field Late-Phase Fluorescein Angiography (LPUWF-LDM) effectively reconstructs fine details in late-phase UWF-FA and achieves state-of-the-art results compared to other existing methods when working with limited datasets. Our source code is available at: https://github.com/Tinysqua/****. △ Less

Submitted 1 September, 2024; originally announced September 2024.

Comments: 13 pages, 7 figures

TC-KANRecon: High-Quality and Accelerated MRI Reconstruction via Adaptive KAN Mechanisms and Intelligent Feature Scaling

Authors: Ruiquan Ge, Xiao Yu, Yifei Chen, Guanyu Zhou, Fan Jia, Shenghao Zhu, Junhao Jia, Chenyan Zhang, Yifei Sun, Dong Zeng, Changmiao Wang, Qiegen Liu, Shanzhou Niu

Abstract: Magnetic Resonance Imaging (MRI) has become essential in clinical diagnosis due to its high resolution and multiple contrast mechanisms. However, the relatively long acquisition time limits its broader application. To address this issue, this study presents an innovative conditional guided diffusion model, named as TC-KANRecon, which incorporates the Multi-Free U-KAN (MF-UKAN) module and a dynamic… ▽ More Magnetic Resonance Imaging (MRI) has become essential in clinical diagnosis due to its high resolution and multiple contrast mechanisms. However, the relatively long acquisition time limits its broader application. To address this issue, this study presents an innovative conditional guided diffusion model, named as TC-KANRecon, which incorporates the Multi-Free U-KAN (MF-UKAN) module and a dynamic clipping strategy. TC-KANRecon model aims to accelerate the MRI reconstruction process through deep learning methods while maintaining the quality of the reconstructed images. The MF-UKAN module can effectively balance the tradeoff between image denoising and structure preservation. Specifically, it presents the multi-head attention mechanisms and scalar modulation factors, which significantly enhances the model's robustness and structure preservation capabilities in complex noise environments. Moreover, the dynamic clipping strategy in TC-KANRecon adjusts the cropping interval according to the sampling steps, thereby mitigating image detail loss typicalching the visual features of the images. Furthermore, the MC-Model incorporates full-sampling k-space information, realizing efficient fusion of conditional information, enhancing the model's ability to process complex data, and improving the realism and detail richness of reconstructed images. Experimental results demonstrate that the proposed method outperforms other MRI reconstruction methods in both qualitative and quantitative evaluations. Notably, TC-KANRecon method exhibits excellent reconstruction results when processing high-noise, low-sampling-rate MRI data. Our source code is available at https://github.com/lcbkmm/TC-KANRecon. △ Less

Submitted 6 January, 2025; v1 submitted 11 August, 2024; originally announced August 2024.

Comments: 11 pages, 3 figures

ReCaLL: Membership Inference via Relative Conditional Log-Likelihoods

Authors: Roy Xie, Junlin Wang, Ruomin Huang, Minxing Zhang, Rong Ge, Jian Pei, Neil Zhenqiang Gong, Bhuwan Dhingra

Abstract: The rapid scaling of large language models (LLMs) has raised concerns about the transparency and fair use of the data used in their pretraining. Detecting such content is challenging due to the scale of the data and limited exposure of each instance during training. We propose ReCaLL (Relative Conditional Log-Likelihood), a novel membership inference attack (MIA) to detect LLMs' pretraining data b… ▽ More The rapid scaling of large language models (LLMs) has raised concerns about the transparency and fair use of the data used in their pretraining. Detecting such content is challenging due to the scale of the data and limited exposure of each instance during training. We propose ReCaLL (Relative Conditional Log-Likelihood), a novel membership inference attack (MIA) to detect LLMs' pretraining data by leveraging their conditional language modeling capabilities. ReCaLL examines the relative change in conditional log-likelihoods when prefixing target data points with non-member context. Our empirical findings show that conditioning member data on non-member prefixes induces a larger decrease in log-likelihood compared to non-member data. We conduct comprehensive experiments and show that ReCaLL achieves state-of-the-art performance on the WikiMIA dataset, even with random and synthetic prefixes, and can be further improved using an ensemble approach. Moreover, we conduct an in-depth analysis of LLMs' behavior with different membership contexts, providing insights into how LLMs leverage membership information for effective inference at both the sequence and token level. △ Less

Submitted 23 May, 2025; v1 submitted 22 June, 2024; originally announced June 2024.

Comments: Accepted to EMNLP 2024 Main Conference