Showing 1–1 of 1 results for author: Geso, M
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Simulation study of dose enhancement in a cell due to nearby carbon and oxygen in particle radiotherapy
Authors:
Jae Ik Shin,
Ilsung Cho,
Sungho Cho,
Eun Ho Kim,
Yongkeun Song,
Won-Gyun Jung,
SeungHoon Yoo,
Dongho Shin,
Se Byeong Lee,
Myonggeun Yoon,
Sebastian Incerti,
Moshi Geso,
Anatoly B. Rosenfeld
Abstract:
The aim of this study is to investigate the dose-deposition enhancement by alpha-particle irradiation in a cellular model using carbon and oxygen chemical compositions.A simulation study was performed to study dose enhancement due to carbon and oxygen for a human cell where Geant4 code used for the alpha-particle irradiation to the cellular phantom. The characteristic of dose enhancement in the nu…
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The aim of this study is to investigate the dose-deposition enhancement by alpha-particle irradiation in a cellular model using carbon and oxygen chemical compositions.A simulation study was performed to study dose enhancement due to carbon and oxygen for a human cell where Geant4 code used for the alpha-particle irradiation to the cellular phantom. The characteristic of dose enhancement in the nucleus and cytoplasm by the alpha-particle radiation was investigated based on concentrations of the carbon and oxygen compositions and was compared with those by gold and gadolinium.The results show that both the carbon and oxygen-induced dose enhancement was found to be more effective than those of gold and gadolinium. We found that the dose-enhancement effect was more dominant in the nucleus than in the cytoplasm if carbon or oxygen is uniformly distributed in a whole cell. In the condition that the added chemical composition was inserted only into the cytoplasm, the effect of the dose enhancement in nucleus becomes weak.We showed that high-stopping-power materials offer a more effective dose-enhancement efficacy and suggest that the carbon nanotubes and oxygenation are promising candidates for dose utilization as dose enhancement tools in particle therapy.
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Submitted 12 March, 2015;
originally announced March 2015.