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The authors reveal that the ferroelectric to antiferroelectric phase transition in Pb(Zr_0.97Ti_0.03)O₃-1wt%Nb₂O₅ at low temperatures is an irreversible process exhibiting relaxation behavior and diffusional kinetics.

Quantum error mitigation refers to techniques that reduce, rather than correct, errors in quantum computing. Here the authors demonstrate zero-noise extrapolation applied to quantum error correction circuits on superconducting processors, effectively reducing logical errors and advancing early fault-tolerant quantum computing.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

The authors introduce an evidential deep learning framework for machine learning interatomic potentials that efficiently provides robust uncertainty quantification, demonstrating its effectiveness across diverse atomic systems.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Adsorbate-mediated strong metal–support interaction is important but mechanistically hard to tune. Facet-resolved Ni/TiO₂ reveals adsorbates trigger and stabilise TiO_2-x overlayers, allowing CO vs CH₄ selectivity control via interfacial electronic effects.

The electrosynthesis of amino acids is hindered by inefficient oxime intermediate conversion. Here, a relayed electron transfer mechanism is proposed using an ionic-liquid@Bi catalyst. Electrons are accepted by the ionic liquid to generate related radicals, which then transfer electrons to oxime, enabling efficient amino acid production.

Liver metastasis remains a leading cause of colorectal cancer mortality. This study identifies different neutrophil subtypes involved in metastasis, highlighting therapeutic potential of neutrophil subset targeting to inhibit tumor progression.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

The reactive nitrogen (Nr)-driven atmospheric multiphase buffering can induce unintended Concomitant Pollution. Given the importance of NH₃ in this process, rising global NH₃ emissions has positioned Concomitant Pollution as an urgent challenge.

FcγRIIb captures its ligand and targets it to lysosomal degradation following endocytosis. Here authors design bispecific-antibody-like molecules they call FcγRIIb-targeting chimeras or FcRTACs, to capture antigens with one arm and degrade them via an FcγRIIb-binding second arm to promote the clearance of pathological protein aggregates.

DNA is a transformative storage medium, but flexible encoding and secure encryption remain challenging. Here, the authors present a DNA condensate-based system capable of writing, erasing, rewriting, replicating, and repairing information, while supporting versatile encryption.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

Insertion of a long DNA sequence into the host genome is challenging in mammalian cells. Here, the authors develop a recombinase (Redα/β)-enhanced DNA integration approach, which enables efficient and precise kilobase-scale DNA insertion in both primary cells and mouse embryos.

Volumetric Localization Microscopy (VLM) integrates light-field imaging with deep learning for high-fidelity 3D single-molecule imaging. Trained on system-aware PSFs, VLM offers simple, efficient, low-toxicity 3D imaging for biomedical research.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Amorphous films with tunable thermal conductivity are needed for semiconductor/aerospace fields. Amorphous Al(Ti)N nanoparticles have negligible effect on thermal conductivity of Si₃N₄ 2 W m⁻¹K⁻¹, while incorporating crystal TiN phases increases to 15 W m⁻¹K⁻¹.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Whole-genome sequencing coupled with whole-exome sequencing validation in Han Chinese patients reveals a diverse genetic basis for venous thromboembolism, and identifies GP6, TET2, and JAK2 as novel risk factors in East Asian populations.

Moiré structures often exhibit long-range order. Here, the authors use scanning tunneling microscopy to identify an incommensurate moiré structure with a short-range-ordered charge density modulation.

In the drier loess soil, Gammaproteobacteria possess symbiotic nitrogen-fixing genes that promote microbial structural and functional succession over the ten-thousand-year scale and support a nitrogen fixation-comammox-nitrate reduction cycle, according to analysis of samples in Luochuan, China.

Exemplified by Bi_0.4Sb_1.6Te₃, the authors reveal the reason for low thermal conductivity induced by compositional inhomogeneity lies in randomly aligned edge dislocations induced by random composition distribution.

In this work, authors present a nanoinducer (bacNID), which enables targeted bacterial protein degradation via ClpXP, leading to the effective treatment of bacterial infection (Staphylococcus aureus and Salmonella typhimurium) without inducing resistance.

A majority methylammonium and iodine edge termination is observed by electron ptychography in the perovskite methylammonium lead iodide, and the stability of its edges and internal defects depends on the concentration and type of vacancies present.

A memristor is the missing fourth circuit element that remembers its bias history. The storage in established devices today occurs by binary switching between ON and OFF states due to filamentary or interfacial mechanisms. Here, Aoki et al.show an analogue-type, homogeneous switching memristor system based on gallium oxide.

Synaptic connectivity is fundamental to brain function. Liao et al. characterized the complex formed between secreted C1ql1 and the adhesion GPCR BAI3, unveiling a C1ql1-mediated assembly mechanism for synaptic connectivity in cerebral neurons.

An analogue memory built from a two-dimensional material with antimony contacts enables very high, energy-efficient in-memory searches and k-nearest-neighbour classification, offering a scalable, low-power hardware platform for real-time edge artificial intelligence applications.

The aphelinid parasitoid Encarsia formosa detects visual cues of competition from Eretmocerus hayati and hormonally adjusts its reproductive strategy, increasing egg production but reducing offspring survival as an adaptive response to competitive environments.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Applying universal AI models across multiple modalities remains challenging. Here, the authors present a model that enables multi-modality whole-body segmentation for computer-aided diagnosis, revealing metabolic correlations across brain, body, and brain–body systems.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

A key mutation conferring maduramicin resistance in Eimeria tenella is identified, and a field-ready molecular assay for rapid detection of ionophore resistance presented.

Eosinophils are involved in eosinophilic airway inflammation such as type 2 asthmatic responses. Here the authors investigate how lysosomes and cathepsin L affect the function and activation of eosinophils and that inhibition of cathepsin L reduces the pathology of allergic asthma in mice models.

Coherence is widely seen as essential for quantum source quality. Here, authors demonstrate on-chip photon states with increased brightness and purity using incoherent light. It reveals the mechanism of pump coherence and lowers the barrier for the generation of high-quality quantum states.

Surface reconstruction during reactions often generates unique active sites that boost catalytic performance. Here, the authors show that supported Ni₃InC₀.₅ nanoparticles undergo CO₂-induced surface oxidation, forming defective In₂O₃₋ₓ layers and inverse In₂O₃₋ₓ/Ni interfaces during CO₂ hydrogenation.

Dinuclear gold complexes have fundamentally expanded catalytic possibilities beyond that of the mononuclear systems. Here the authors report a bidentate mixed-ligand system that can catalyze efficient three-component carbonylative amidation of unactivated alkyl bromides with amines and CO under mild conditions.

Han et.al. report the isolation and characterization of two neutralizing antibodies, C34 and C37, from a convalescent CHIKV patient. These antibodies demonstrate in vitro and in vivo efficacy against Chikungunya virus by targeting an epitope on the E2 protein and blocking the Mxra8 receptor.

How TGF-β regulates liver metastasis remains further investigation. The authors here find that TβRI blockade in hepatocytes decreases liver metastatic progression via revitalizing stem-like CD8⁺ Tex subsets, and an LNP encapsulated with the TβRI inhibitor Galunisertib synergizes with αPD-1 to ameliorate liver metastasis