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A Superposition-Based Framework for Rapid Estimation of Arbitrary Antenna-Array Patterns
Authors:
Amir Dayan,
Nabeel Ali Khan,
Inchara Lakshminarayan,
Wahyudin Syam,
Noori BniLam,
William Whittow,
Aakash Bansal
Abstract:
Antenna array theory is a well-established field. However, a systematic approach for fast pattern estimation in arrays with arbitrary antenna locations and orientations has not yet been developed. In this paper, based on simulated (or measured) radiation patterns of a single element, we present a Superposition-Based Framework (SBF) for numerically computing array radiation patterns in which the po…
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Antenna array theory is a well-established field. However, a systematic approach for fast pattern estimation in arrays with arbitrary antenna locations and orientations has not yet been developed. In this paper, based on simulated (or measured) radiation patterns of a single element, we present a Superposition-Based Framework (SBF) for numerically computing array radiation patterns in which the positions and orientations of the antenna elements can be readily modified. To validate the framework, a compact dual-layer circularly polarized patch antenna at 5.02 GHz (ESA's Celeste frequency) is designed and used as an array element in an 8-element ring antenna. Using the proposed framework and the single-element far-field pattern, the array radiation pattern is computed in 13s (excluding single-element simulation time), which is at least 50 times faster than the corresponding full-wave simulation while maintaining comparable accuracy. Comparisons with CST simulations show a peak E-field error of less than 0.5% for the intended polarization. Full-wave simulations are memory- and energy-intensive, and hence, impractical for larger arrays. The proposed SBF requires low computational power, making it energy-efficient and sustainable.
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Submitted 10 August, 2026;
originally announced August 2026.
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Operation and performance of ProtoDUNE Dual Phase liquid argon time projection chamber
Authors:
DUNE Collaboration,
S. Abbaslu,
F. Abd Alrahman,
A. Abed Abud,
R. Acciarri,
L. P. Accorsi,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
K. Adhikari,
C. Adriano,
K. Agudelo-Jaramillo,
F. Akbar,
F. Alemanno,
N. S. Alex,
L. Aliaga Soplin,
A. Alqaisi,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
R. Amarinei
, et al. (1341 additional authors not shown)
Abstract:
ProtoDUNE-DP was the largest ever built Liquid Argon Time Projection Chamber (LArTPC) operating in Dual-Phase (DP) mode, with a liquid target and charge read-out placed in the gas. It had an active volume of $6\times6\times6$\,m$^3$ corresponding to an active mass of 300\,t (total LAr mass of 720\,t), constructed at the CERN Neutrino Platform and took data from 2019 to 2020 with cosmic muons. In P…
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ProtoDUNE-DP was the largest ever built Liquid Argon Time Projection Chamber (LArTPC) operating in Dual-Phase (DP) mode, with a liquid target and charge read-out placed in the gas. It had an active volume of $6\times6\times6$\,m$^3$ corresponding to an active mass of 300\,t (total LAr mass of 720\,t), constructed at the CERN Neutrino Platform and took data from 2019 to 2020 with cosmic muons. In ProtoDUNE-DP the electric drift field is oriented in the vertical direction, causing the electrons to drift vertically towards the anode at the top. The ionization charge is then extracted into the gaseous argon above the liquid surface, amplified by Townsend avalanches, and collected by the charge readout planes. The detector experienced significant technical problems affecting the long-term operation of the Charge Readout Planes, formed by the Large Electron Multipliers, but other critical segments demonstrated required performance including the delivery of -300 kV to the TPC cathode, verification of replaceable charge read-out electronics, and operation of the photon detection system. ProtoDUNE-DP experience resulted in improved designs of the Vertical Drift LArTPC.
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Submitted 21 July, 2026; v1 submitted 17 July, 2026;
originally announced July 2026.
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Leveraging Population Dynamics to Steer Efficient Search in Large-Scale Combinatorial Optimization
Authors:
Nikhat Khan,
Ridge Redding,
Nikhil Shukla
Abstract:
Combinatorial optimization problems pose substantial computational challenges because their feasible solution spaces grow exponentially with problem size. This paper presents a GPU-accelerated augmented Population Annealing Monte Carlo (PAMC) framework for large-scale graph-partitioning problems, with emphasis on Max-Cut and Max-K-Cut. The proposed framework extends conventional PAMC by coupling p…
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Combinatorial optimization problems pose substantial computational challenges because their feasible solution spaces grow exponentially with problem size. This paper presents a GPU-accelerated augmented Population Annealing Monte Carlo (PAMC) framework for large-scale graph-partitioning problems, with emphasis on Max-Cut and Max-K-Cut. The proposed framework extends conventional PAMC by coupling population-based resampling with two stagnation-driven mechanisms: adaptive temperature control and energy-preserving nonlocal cluster moves. By using population-level optimization history as feedback, these mechanisms regulate the balance between exploration and refinement by reheating stalled populations and enabling collective transitions across locally confined regions of the solution space. Experiments on G-set benchmark instances show that the augmented PAMC framework achieves competitive or lower time-to-solution than reported state-of-the-art baselines on several large Max-Cut instances, while matching or improving solution quality under comparable runtime budgets. The solver also discovers a new best-known solution for the G63 Max-Cut instance and scales to a fully connected 100,000-spin Ising instance. For Max-3-Cut, the same framework establishes new best-known solutions on 36 G-set instances, demonstrating its applicability beyond binary Ising formulations. These results indicate that feedback-controlled population dynamics provide an effective and scalable strategy for steering stochastic search in large-scale combinatorial optimization.
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Submitted 23 June, 2026;
originally announced June 2026.
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Enhancing Speckle Metrology with Diffusion Denoising in Photon-Starved Regimes
Authors:
Admir Bajraktarevic,
Alexander C. Trowbridge,
Saba N. Khan,
Anton van den Hengel,
Graham D. Bruce,
Kishan Dholakia
Abstract:
Laser speckle is a powerful tool for precision metrology that enables highly sensitive measurements of light sources and subtle environmental perturbations. Many applications require operation in photon-limited regimes, for example when using low-power illumination or in spectral regions where sensitive detectors are unavailable. In these conditions, the structured speckle pattern that encodes the…
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Laser speckle is a powerful tool for precision metrology that enables highly sensitive measurements of light sources and subtle environmental perturbations. Many applications require operation in photon-limited regimes, for example when using low-power illumination or in spectral regions where sensitive detectors are unavailable. In these conditions, the structured speckle pattern that encodes the signal becomes challenging to disentangle from measurement noise, severely degrading performance. Here, we introduce a denoising framework to separate measurement noise from the underlying speckle structure in low-signal data. Using a hybrid pre-training and experimental fine-tuning strategy, the model is adapted using a small experimental dataset and integrates directly with existing speckle metrology pipelines. Applied to femtometre-scale wavelength sensing using an integrating sphere, the approach reduces root-mean-square error in low-signal conditions by up to 72% and enables accurate reconstruction where conventional speckle metrology fails.
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Submitted 23 June, 2026;
originally announced June 2026.
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Charge readout electronics for the DUNE horizontal drift far detector: design and performance in ProtoDUNE-HD
Authors:
DUNE Collaboration,
S. Abbaslu,
F. Abd Alrahman,
A. Abed Abud,
R. Acciarri,
L. P. Accorsi,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
K. Adhikari,
C. Adriano,
K. Agudelo-Jaramillo,
F. Akbar,
F. Alemanno,
N. S. Alex,
L. Aliaga Soplin,
A. Alqaisi,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
R. Amarinei
, et al. (1346 additional authors not shown)
Abstract:
DUNE (Deep Underground Neutrino Experiment) is a long-baseline neutrino oscillation experiment currently under construction, whose far detectors will be the largest liquid argon time projection chambers ever built. This detector design calls for custom-built cryogenic front-end electronics to meet its performance requirements. This paper describes the charge readout electronics that will be used i…
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DUNE (Deep Underground Neutrino Experiment) is a long-baseline neutrino oscillation experiment currently under construction, whose far detectors will be the largest liquid argon time projection chambers ever built. This detector design calls for custom-built cryogenic front-end electronics to meet its performance requirements. This paper describes the charge readout electronics that will be used in the DUNE horizontal drift (HD) far detector and presents performance results using data from the ProtoDUNE-HD detector, a 770 ton liquid argon time projection chamber operated at the CERN Neutrino Platform in 2024 that served as the final prototype of the DUNE HD design.
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Submitted 12 August, 2026; v1 submitted 26 April, 2026;
originally announced April 2026.
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Manipulation of the orbital angular momentum of soft x-ray beams by consecutive diffractive optics
Authors:
Nazir Khan,
Rahul Jangid,
Taras Stanislavchuk,
Aaron Stein,
Oleg Chubar,
Andi Barbour,
Andrei Sirenko,
Valery Kiryukhin,
Claudio Mazzoli
Abstract:
Production and manipulation of orbital angular momentum (OAM) of coherent soft x-ray beams is demonstrated utilizing consecutive diffractive optics. OAM addition is observed upon passing the beam through consecutive fork gratings. The OAM of the beam was found to be decoupled from its spin angular momentum (SAM). Practical implementation of angular momentum control by consecutive devices in the x-…
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Production and manipulation of orbital angular momentum (OAM) of coherent soft x-ray beams is demonstrated utilizing consecutive diffractive optics. OAM addition is observed upon passing the beam through consecutive fork gratings. The OAM of the beam was found to be decoupled from its spin angular momentum (SAM). Practical implementation of angular momentum control by consecutive devices in the x-ray regime opens new experimental opportunities, such as direct measurement of OAM beams without resorting to phase sensitive techniques, including holography. OAM analyzers utilizing fork gratings can be used to characterize the beams produced by synchrotron and free electron lasers sources; they can also be used in scattering experiments.
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Submitted 21 November, 2025;
originally announced November 2025.
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Operation of a Modular 3D-Pixelated Liquid Argon Time-Projection Chamber in a Neutrino Beam
Authors:
DUNE Collaboration,
S. Abbaslu,
A. Abed Abud,
R. Acciarri,
L. P. Accorsi,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
C. Adriano,
F. Akbar,
F. Alemanno,
N. S. Alex,
K. Allison,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade,
C. Andreopoulos,
M. Andreotti
, et al. (1299 additional authors not shown)
Abstract:
The 2x2 Demonstrator, a prototype for the Deep Underground Neutrino Experiment (DUNE) liquid argon (LAr) Near Detector, was exposed to the Neutrinos from the Main Injector (NuMI) neutrino beam at Fermi National Accelerator Laboratory (Fermilab). This detector prototypes a new modular design for a liquid argon time-projection chamber (LArTPC), comprised of a two-by-two array of four modules, each f…
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The 2x2 Demonstrator, a prototype for the Deep Underground Neutrino Experiment (DUNE) liquid argon (LAr) Near Detector, was exposed to the Neutrinos from the Main Injector (NuMI) neutrino beam at Fermi National Accelerator Laboratory (Fermilab). This detector prototypes a new modular design for a liquid argon time-projection chamber (LArTPC), comprised of a two-by-two array of four modules, each further segmented into two optically-isolated LArTPCs. The 2x2 Demonstrator features a number of pioneering technologies, including a low-profile resistive field shell to establish drift fields, native 3D ionization pixelated imaging, and a high-coverage dielectric light readout system. The 2.4 tonne active mass detector is flanked upstream and downstream by supplemental solid-scintillator tracking planes, repurposed from the MINERvA experiment, which track ionizing particles exiting the argon volume. The antineutrino beam data collected by the detector over a 4.5 day period in 2024 include over 30,000 neutrino interactions in the LAr active volume-the first neutrino interactions reported by a DUNE detector prototype. During its physics-quality run, the 2x2 Demonstrator operated at a nominal drift field of 500 V/cm and maintained good LAr purity, with a stable electron lifetime of approximately 1.25 ms. This paper describes the detector and supporting systems, summarizes the installation and commissioning, and presents the initial validation of collected NuMI beam and off-beam self-triggers. In addition, it highlights observed interactions in the detector volume, including candidate muon anti-neutrino events.
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Submitted 17 June, 2026; v1 submitted 6 September, 2025;
originally announced September 2025.
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Bridging the Analog and the Probabilistic Computing Divide: Configuring Oscillator Ising Machines as P-bit Engines
Authors:
E. M. Hasantha Ekanayake,
Nikhat Khan,
Nikhil Shukla
Abstract:
Oscillator Ising Machines (OIMs) and probabilistic bit (p-bit)-based computing platforms have emerged as promising paradigms for tackling complex combinatorial optimization problems. Although traditionally viewed as distinct approaches, this work presents a theoretically grounded framework for configuring OIMs as p-bit engines. We demonstrate that this functionality can be enabled through a novel…
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Oscillator Ising Machines (OIMs) and probabilistic bit (p-bit)-based computing platforms have emerged as promising paradigms for tackling complex combinatorial optimization problems. Although traditionally viewed as distinct approaches, this work presents a theoretically grounded framework for configuring OIMs as p-bit engines. We demonstrate that this functionality can be enabled through a novel interplay between first- and second harmonic injection to the oscillators. Our work identifies new synergies between the two methods and broadens the scope of applications for OIMs. We further show that the proposed approach can be applied to other analog dynamical systems, such as the Dynamical Ising Machine.
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Submitted 22 January, 2026; v1 submitted 21 August, 2025;
originally announced August 2025.
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Readout electronics for low occupancy High-Pressure Gas TPCs
Authors:
N. Khan,
Y. Hua,
I. Xiotidis,
T. Alves,
E. Atkin,
G. Barker,
D. Barrow,
A. Booth,
J. Borg,
A. Bross,
M. F. Cicala,
L. Cremonesi,
A. Deisting,
K. Duffy,
R. Gran,
P. Green,
A. Habig,
M. Judah,
T. Junk,
A. Kaboth,
A. Klustová,
H. LeMoine,
A. D. Marino,
F. Martínez López,
T. Mohayai
, et al. (14 additional authors not shown)
Abstract:
HPgTPCs have benefits such as low energy threshold, magnetisability, and 4$π$ acceptance, making them ideal for neutrino experiments such as DUNE. We present the design of an FPGA-based solution optimised for ND-GAr, which is part of the Phase-II more capable near detector for DUNE. These electronics reduce the cost significantly compared to using collider readout electronics which are typically d…
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HPgTPCs have benefits such as low energy threshold, magnetisability, and 4$π$ acceptance, making them ideal for neutrino experiments such as DUNE. We present the design of an FPGA-based solution optimised for ND-GAr, which is part of the Phase-II more capable near detector for DUNE. These electronics reduce the cost significantly compared to using collider readout electronics which are typically designed for much higher occupancy and therefore, for example, need much larger numbers of FPGAs and power per channel. We demonstrate the performance of our electronics with the TOAD at Fermilab in the US at a range of pressures and gas mixtures up to 4.5barA, reading out ~10000 channels from a multi-wire proportional chamber. The operation took place between April and July of 2024. We measure the noise characteristics of the system to be sufficiently low and we identify sources of noise that can be further mitigated in the next iteration. We also note that the cooling scheme used in the test requires improvement before full-scale deployment. Despite these necessary improvements, we show that the system can fulfil the needs of a HPgTPC for a fraction of the price of collider readout electronics.
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Submitted 21 October, 2025; v1 submitted 23 July, 2025;
originally announced July 2025.
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Spatial and Temporal Evaluations of the Liquid Argon Purity in ProtoDUNE-SP
Authors:
DUNE Collaboration,
S. Abbaslu,
A. Abed Abud,
R. Acciarri,
L. P. Accorsi,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
C. Adriano,
F. Akbar,
F. Alemanno,
N. S. Alex,
K. Allison,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade,
C. Andreopoulos,
M. Andreotti
, et al. (1301 additional authors not shown)
Abstract:
Liquid argon time projection chambers (LArTPCs) rely on highly pure argon to ensure that ionization electrons produced by charged particles reach readout arrays. ProtoDUNE Single-Phase (ProtoDUNE-SP) was an approximately 700-ton liquid argon detector intended to prototype the Deep Underground Neutrino Experiment (DUNE) Far Detector Horizontal Drift module. It contains two drift volumes bisected by…
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Liquid argon time projection chambers (LArTPCs) rely on highly pure argon to ensure that ionization electrons produced by charged particles reach readout arrays. ProtoDUNE Single-Phase (ProtoDUNE-SP) was an approximately 700-ton liquid argon detector intended to prototype the Deep Underground Neutrino Experiment (DUNE) Far Detector Horizontal Drift module. It contains two drift volumes bisected by the cathode plane assembly, which is biased to create an almost uniform electric field in both volumes. The DUNE Far Detector modules must have robust cryogenic systems capable of filtering argon and supplying the TPC with clean liquid. This paper will explore comparisons of the argon purity measured by the purity monitors with those measured using muons in the TPC from October 2018 to November 2018. A new method is introduced to measure the liquid argon purity in the TPC using muons crossing both drift volumes of ProtoDUNE-SP. For extended periods on the timescale of weeks, the drift electron lifetime was measured to be above 30 ms using both systems. A particular focus will be placed on the measured purity of argon as a function of position in the detector.
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Submitted 27 August, 2025; v1 submitted 11 July, 2025;
originally announced July 2025.
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European Contributions to Fermilab Accelerator Upgrades and Facilities for the DUNE Experiment
Authors:
DUNE Collaboration,
A. Abed Abud,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
F. Alemanno,
N. S. Alex,
K. Allison,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade
, et al. (1322 additional authors not shown)
Abstract:
The Proton Improvement Plan (PIP-II) to the FNAL accelerator chain and the Long-Baseline Neutrino Facility (LBNF) will provide the world's most intense neutrino beam to the Deep Underground Neutrino Experiment (DUNE) enabling a wide-ranging physics program. This document outlines the significant contributions made by European national laboratories and institutes towards realizing the first phase o…
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The Proton Improvement Plan (PIP-II) to the FNAL accelerator chain and the Long-Baseline Neutrino Facility (LBNF) will provide the world's most intense neutrino beam to the Deep Underground Neutrino Experiment (DUNE) enabling a wide-ranging physics program. This document outlines the significant contributions made by European national laboratories and institutes towards realizing the first phase of the project with a 1.2 MW neutrino beam. Construction of this first phase is well underway. For DUNE Phase II, this will be closely followed by an upgrade of the beam power to > 2 MW, for which the European groups again have a key role and which will require the continued support of the European community for machine aspects of neutrino physics. Beyond the neutrino beam aspects, LBNF is also responsible for providing unique infrastructure to install and operate the DUNE neutrino detectors at FNAL and at the Sanford Underground Research Facility (SURF). The cryostats for the first two Liquid Argon Time Projection Chamber detector modules at SURF, a contribution of CERN to LBNF, are central to the success of the ongoing execution of DUNE Phase I. Likewise, successful and timely procurement of cryostats for two additional detector modules at SURF will be critical to the success of DUNE Phase II and the overall physics program. The DUNE Collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This paper is being submitted to the 'Accelerator technologies' and 'Projects and Large Experiments' streams. Additional inputs related to the DUNE science program, DUNE detector technologies and R&D, and DUNE software and computing, are also being submitted to other streams.
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Submitted 31 March, 2025;
originally announced March 2025.
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DUNE Software and Computing Research and Development
Authors:
DUNE Collaboration,
A. Abed Abud,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
F. Alemanno,
N. S. Alex,
K. Allison,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade
, et al. (1322 additional authors not shown)
Abstract:
The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The ambitious physics program of Phase I and Phase II of DUNE is dependent upon deployment and utilization of significant computing res…
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The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The ambitious physics program of Phase I and Phase II of DUNE is dependent upon deployment and utilization of significant computing resources, and successful research and development of software (both infrastructure and algorithmic) in order to achieve these scientific goals. This submission discusses the computing resources projections, infrastructure support, and software development needed for DUNE during the coming decades as an input to the European Strategy for Particle Physics Update for 2026. The DUNE collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This submission to the 'Computing' stream focuses on DUNE software and computing. Additional inputs related to the DUNE science program, DUNE detector technologies and R&D, and European contributions to Fermilab accelerator upgrades and facilities for the DUNE experiment, are also being submitted to other streams.
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Submitted 31 March, 2025;
originally announced March 2025.
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The DUNE Phase II Detectors
Authors:
DUNE Collaboration,
A. Abed Abud,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
F. Alemanno,
N. S. Alex,
K. Allison,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
A. Aman,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade
, et al. (1322 additional authors not shown)
Abstract:
The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy for the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and…
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The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy for the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the previous European Strategy for Particle Physics. The construction of DUNE Phase I is well underway. DUNE Phase II consists of a third and fourth far detector module, an upgraded near detector complex, and an enhanced > 2 MW beam. The fourth FD module is conceived as a 'Module of Opportunity', aimed at supporting the core DUNE science program while also expanding the physics opportunities with more advanced technologies. The DUNE collaboration is submitting four main contributions to the 2026 Update of the European Strategy for Particle Physics process. This submission to the 'Detector instrumentation' stream focuses on technologies and R&D for the DUNE Phase II detectors. Additional inputs related to the DUNE science program, DUNE software and computing, and European contributions to Fermilab accelerator upgrades and facilities for the DUNE experiment, are also being submitted to other streams.
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Submitted 29 March, 2025;
originally announced March 2025.
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The track-length extension fitting algorithm for energy measurement of interacting particles in liquid argon TPCs and its performance with ProtoDUNE-SP data
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
N. S. Alex,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
H. Amar,
P. Amedo,
J. Anderson,
C. Andreopoulos
, et al. (1348 additional authors not shown)
Abstract:
This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy los…
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This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy loss as a function of the energy, including models of electron recombination and detector response. The algorithm can be used to measure the energies of particles that interact before they stop, such as charged pions that are absorbed by argon nuclei. The algorithm's energy measurement resolutions and fractional biases are presented as functions of particle kinetic energy and number of track hits using samples of stopping secondary charged pions in data collected by the ProtoDUNE-SP detector, and also in a detailed simulation. Additional studies describe the impact of the dE/dx model on energy measurement performance. The method described in this paper to characterize the energy measurement performance can be repeated in any LArTPC experiment using stopping secondary charged pions.
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Submitted 26 December, 2024; v1 submitted 26 September, 2024;
originally announced September 2024.
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DUNE Phase II: Scientific Opportunities, Detector Concepts, Technological Solutions
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
H. Amar,
P. Amedo,
J. Anderson,
C. Andreopoulos,
M. Andreotti
, et al. (1347 additional authors not shown)
Abstract:
The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I…
▽ More
The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the European Strategy for Particle Physics. While the construction of the DUNE Phase I is well underway, this White Paper focuses on DUNE Phase II planning. DUNE Phase-II consists of a third and fourth far detector (FD) module, an upgraded near detector complex, and an enhanced 2.1 MW beam. The fourth FD module is conceived as a "Module of Opportunity", aimed at expanding the physics opportunities, in addition to supporting the core DUNE science program, with more advanced technologies. This document highlights the increased science opportunities offered by the DUNE Phase II near and far detectors, including long-baseline neutrino oscillation physics, neutrino astrophysics, and physics beyond the standard model. It describes the DUNE Phase II near and far detector technologies and detector design concepts that are currently under consideration. A summary of key R&D goals and prototyping phases needed to realize the Phase II detector technical designs is also provided. DUNE's Phase II detectors, along with the increased beam power, will complete the full scope of DUNE, enabling a multi-decadal program of groundbreaking science with neutrinos.
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Submitted 22 August, 2024;
originally announced August 2024.
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First Measurement of the Total Inelastic Cross-Section of Positively-Charged Kaons on Argon at Energies Between 5.0 and 7.5 GeV
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
H. Amar,
P. Amedo,
J. Anderson,
C. Andreopoulos,
M. Andreotti
, et al. (1341 additional authors not shown)
Abstract:
ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each…
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ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each beam momentum setting was measured to be 380$\pm$26 mbarns for the 6 GeV/$c$ setting and 379$\pm$35 mbarns for the 7 GeV/$c$ setting.
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Submitted 1 August, 2024;
originally announced August 2024.
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Supernova Pointing Capabilities of DUNE
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
B. Aimard,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade
, et al. (1340 additional authors not shown)
Abstract:
The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electr…
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The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electron-neutrino charged-current absorption on 40Ar and elastic scattering of neutrinos on electrons. Procedures to reconstruct individual interactions, including a newly developed technique called ``brems flipping'', as well as the burst direction from an ensemble of interactions are described. Performance of the burst direction reconstruction is evaluated for supernovae happening at a distance of 10 kpc for a specific supernova burst flux model. The pointing resolution is found to be 3.4 degrees at 68% coverage for a perfect interaction-channel classification and a fiducial mass of 40 kton, and 6.6 degrees for a 10 kton fiducial mass respectively. Assuming a 4% rate of charged-current interactions being misidentified as elastic scattering, DUNE's burst pointing resolution is found to be 4.3 degrees (8.7 degrees) at 68% coverage.
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Submitted 24 December, 2025; v1 submitted 14 July, 2024;
originally announced July 2024.
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Determining intrinsic sensitivity and the role of multiple scattering in speckle metrology
Authors:
Morgan Facchin,
Saba N. Khan,
Kishan Dholakia,
Graham D. Bruce
Abstract:
Speckle patterns are a powerful tool for high-precision metrology, as they allow remarkable performance in relatively simple setups. Nonetheless, researchers in this field follow rather distinct paths due to underappreciated general principles underlying speckle phenomena. Here, we advise on a universal metric of intrinsic speckle sensitivity, and on the advantages and disadvantages of multiple sc…
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Speckle patterns are a powerful tool for high-precision metrology, as they allow remarkable performance in relatively simple setups. Nonetheless, researchers in this field follow rather distinct paths due to underappreciated general principles underlying speckle phenomena. Here, we advise on a universal metric of intrinsic speckle sensitivity, and on the advantages and disadvantages of multiple scattering. This will catalyse progress in speckle metrology but will also translate to other domains of disordered optics which are undergoing rapid developments at present.
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Submitted 15 August, 2024; v1 submitted 28 March, 2024;
originally announced March 2024.
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Performance of a modular ton-scale pixel-readout liquid argon time projection chamber
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
B. Aimard,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
T. Alves,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade
, et al. (1340 additional authors not shown)
Abstract:
The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmi…
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The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements, and provide comparisons to detector simulations.
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Submitted 5 March, 2024;
originally announced March 2024.
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Doping Liquid Argon with Xenon in ProtoDUNE Single-Phase: Effects on Scintillation Light
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
B. Aimard,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
H. Amar Es-sghir,
P. Amedo,
J. Anderson,
D. A. Andrade,
C. Andreopoulos
, et al. (1297 additional authors not shown)
Abstract:
Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUN…
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Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 720 t of total liquid argon mass with 410 t of fiducial mass. A 5.4 ppm nitrogen contamination was present during the xenon doping campaign. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of non-uniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen.
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Submitted 2 August, 2024; v1 submitted 2 February, 2024;
originally announced February 2024.
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Observation of period-doubling Bloch oscillations
Authors:
Naveed Khan,
Peng Wang,
Qidong Fu,
Ce Shang,
Fangwei Ye
Abstract:
Bloch oscillations refer to the periodic oscillation of a wavepacket in a lattice under a constant force. Typically, the oscillation has a fundamental period that corresponds to the wavepacket traversing the first Brillouin zone once. Here we demonstrate, both theoretically and experimentally, the optical Bloch oscillations where the wavepacket must traverse the first Brillouin zone twice to compl…
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Bloch oscillations refer to the periodic oscillation of a wavepacket in a lattice under a constant force. Typically, the oscillation has a fundamental period that corresponds to the wavepacket traversing the first Brillouin zone once. Here we demonstrate, both theoretically and experimentally, the optical Bloch oscillations where the wavepacket must traverse the first Brillouin zone twice to complete a full cycle, resulting in a period of oscillation that is two times longer than that of usual Bloch oscillations. The unusual Bloch oscillations arise due to the band crossing of valley-Hall topological edge states at the Brillouin boundary for zigzag domain walls between two staggered honeycomb lattices with inverted on-site energy detuning, which are protected by the glide-reflection symmetry of the underlying structures. Our work sheds light on the direct detection of band crossings resulting from intrinsic symmetries that extend beyond the fundamental translational symmetry in topological systems.
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Submitted 18 January, 2024;
originally announced January 2024.
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The DUNE Far Detector Vertical Drift Technology, Technical Design Report
Authors:
DUNE Collaboration,
A. Abed Abud,
B. Abi,
R. Acciarri,
M. A. Acero,
M. R. Adames,
G. Adamov,
M. Adamowski,
D. Adams,
M. Adinolfi,
C. Adriano,
A. Aduszkiewicz,
J. Aguilar,
B. Aimard,
F. Akbar,
K. Allison,
S. Alonso Monsalve,
M. Alrashed,
A. Alton,
R. Alvarez,
H. Amar,
P. Amedo,
J. Anderson,
D. A. Andrade,
C. Andreopoulos
, et al. (1304 additional authors not shown)
Abstract:
DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precisi…
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DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model.
The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise.
In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered.
This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals.
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Submitted 5 December, 2023;
originally announced December 2023.
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Fano resonance-assisted all-dielectric array for enhanced near-field optical trapping of nanoparticles
Authors:
Donato Conteduca,
Saba N. Khan,
Manuel A. Martínez Ruiz,
Graham D. Bruce,
Thomas F. Krauss,
Kishan Dholakia
Abstract:
Near-field optics can overcome the diffraction limit by creating strong optical gradients to enable the trapping of nanoparticles. However, it remains challenging to achieve efficient stable trapping without heating and thermal effects. Dielectric structures have been used to address this issue, but they usually offer weak trap stiffness. In this work, we exploit the Fano resonance effect in an al…
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Near-field optics can overcome the diffraction limit by creating strong optical gradients to enable the trapping of nanoparticles. However, it remains challenging to achieve efficient stable trapping without heating and thermal effects. Dielectric structures have been used to address this issue, but they usually offer weak trap stiffness. In this work, we exploit the Fano resonance effect in an all-dielectric quadrupole nanostructure to realize a twenty-fold enhancement of trap stiffness, compared to the off-resonance case. This enables a high effective trap stiffness of $1.19$ fN/nm for 100 nm diameter polystyrene nanoparticles with 3.5 mW/$μ$m$^{2}$ illumination. Furthermore, we demonstrate the capability of the structure to simultaneously trap two particles at distinct locations within the nanostructure array.
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Submitted 7 August, 2023;
originally announced August 2023.
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First operation of an ALICE OROC operated in high pressure Ar-CO$_{2}$ and Ar-CH$_{4}$
Authors:
A. Ritchie-Yates,
A. Deisting,
G. Barker,
S. Boyd,
D. Brailsford,
Z. Chen-Wishart,
L. Cremonesi,
P. Dunne,
J. Eeles,
P. Hamilton,
A. C. Kaboth,
N. Khan,
A. Klustová,
J. Monroe,
J. Nowak,
P. Singh,
A. V. Waldron,
J. Walding,
L. Warsame,
M. O. Wascko,
I. Xiotidis
Abstract:
New neutrino-nucleus interaction cross-section measurements are required to improve nuclear models sufficiently for future long-baseline neutrino experiments to meet their sensitivity goals. A time projection chamber (TPC) filled with a high-pressure gas is a promising detector to characterise the neutrino sources planned for such experiments. A gas-filled TPC is ideal for measuring low-energy par…
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New neutrino-nucleus interaction cross-section measurements are required to improve nuclear models sufficiently for future long-baseline neutrino experiments to meet their sensitivity goals. A time projection chamber (TPC) filled with a high-pressure gas is a promising detector to characterise the neutrino sources planned for such experiments. A gas-filled TPC is ideal for measuring low-energy particles as they travel much further in gas than solid or liquid neutrino detectors. Using a high-pressure gas increases the target density, resulting in more neutrino interactions. This paper will examine the suitability of multiwire proportional chambers (MWPCs) taken from the ALICE TPC to be used as the readout chambers of a high-pressure gas TPC. These chambers were previously operated at atmospheric pressure. We tested one such MWPC at up to almost 5 bar absolute (barA) with the UK high-pressure test stand at Royal Holloway, University of London. This paper reports the successful operation of an ALICE TPC outer readout chamber (OROC) at pressures up to 4.8 bar absolute with Ar-CH$_{4}$ mixtures with a CH$_{4}$ content between 2.8% and 5.0%, and so far up to 4 bar absolute with Ar-CO$_{2}$ (90-10). We measured the charge gain of this OROC using signals induced by an $^{55}$Fe source. The largest gain achieved at 4.8 bar was $64\pm2)\cdot10^{3}$ at stable conditions with an anode wire voltage of 2990 V in Ar-CH$_{4}$ (95.9-4.1). In Ar-CO$_{2}$ a gain of $(4.2\pm0.1)\cdot10^{3}$ was observed at an anode voltage of 2975 V at 4 barA gas pressure. Based on all our gain measurements, we extrapolate that, at the 10 barA pressure necessary to fit 1 tonne of gas into the ALICE TPC volume, a gain of 5000 in Ar-CO$_{2}$ (90-10) (10000 in Ar-CH$_{4}$ with $\sim\!$ 4% CH$_{4}$ content) may be achieved with an OROC anode voltage of 4.2 V ($\sim\!$ 3.1 kV).
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Submitted 15 May, 2023;
originally announced May 2023.
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Theoretical tools for neutrino scattering: interplay between lattice QCD, EFTs, nuclear physics, phenomenology, and neutrino event generators
Authors:
L. Alvarez Ruso,
A. M. Ankowski,
S. Bacca,
A. B. Balantekin,
J. Carlson,
S. Gardiner,
R. Gonzalez-Jimenez,
R. Gupta,
T. J. Hobbs,
M. Hoferichter,
J. Isaacson,
N. Jachowicz,
W. I. Jay,
T. Katori,
F. Kling,
A. S. Kronfeld,
S. W. Li,
H. -W. Lin,
K. -F. Liu,
A. Lovato,
K. Mahn,
J. Menendez,
A. S. Meyer,
J. Morfin,
S. Pastore
, et al. (36 additional authors not shown)
Abstract:
Maximizing the discovery potential of increasingly precise neutrino experiments will require an improved theoretical understanding of neutrino-nucleus cross sections over a wide range of energies. Low-energy interactions are needed to reconstruct the energies of astrophysical neutrinos from supernovae bursts and search for new physics using increasingly precise measurement of coherent elastic neut…
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Maximizing the discovery potential of increasingly precise neutrino experiments will require an improved theoretical understanding of neutrino-nucleus cross sections over a wide range of energies. Low-energy interactions are needed to reconstruct the energies of astrophysical neutrinos from supernovae bursts and search for new physics using increasingly precise measurement of coherent elastic neutrino scattering. Higher-energy interactions involve a variety of reaction mechanisms including quasi-elastic scattering, resonance production, and deep inelastic scattering that must all be included to reliably predict cross sections for energies relevant to DUNE and other accelerator neutrino experiments. This white paper discusses the theoretical status, challenges, required resources, and path forward for achieving precise predictions of neutrino-nucleus scattering and emphasizes the need for a coordinated theoretical effort involved lattice QCD, nuclear effective theories, phenomenological models of the transition region, and event generators.
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Submitted 20 April, 2022; v1 submitted 16 March, 2022;
originally announced March 2022.
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Coherence-induced Polarization Effects in Vector Vortex Beams
Authors:
Stuti Joshi,
Saba N Khan,
Manisha,
P Senthilkumaran,
Bhaskar Kanseri
Abstract:
We demonstrate theoretically and experimentally coherence-induced polarization changes in generic and higher-order vector vortex beams with polarization singularity. The prominent depolarization on decreasing transverse correlation-width in focused partially coherent vector vortex beam provides a means to shape the intensity profile and the degree of polarization (DOP) while preserving the polariz…
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We demonstrate theoretically and experimentally coherence-induced polarization changes in generic and higher-order vector vortex beams with polarization singularity. The prominent depolarization on decreasing transverse correlation-width in focused partially coherent vector vortex beam provides a means to shape the intensity profile and the degree of polarization (DOP) while preserving the polarization distribution. The intensity variation and DOP-dip are found to be dependent on the polarization singularity index of the beam. Our results may provide an additional degree of freedom in the myriad of applications presently projected with various types of vector vortex beams.
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Submitted 21 July, 2020;
originally announced July 2020.
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Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures
Authors:
Colin Pawlowski,
Tyler Wagner,
Arjun Puranik,
Karthik Murugadoss,
Liam Loscalzo,
AJ Venkatakrishnan,
Rajiv K. Pruthi,
Damon E. Houghton,
John C. OHoro,
William G. Morice II,
John Halamka,
Andrew D. Badley,
Elliot S. Barnathan,
Hideo Makimura,
Najat Khan,
Venky Soundararajan
Abstract:
Temporal inference from laboratory testing results and their triangulation with clinical outcomes as described in the associated unstructured text from the providers notes in the Electronic Health Record (EHR) is integral to advancing precision medicine. Here, we studied 181 COVIDpos and 7,775 COVIDneg patients subjected to 1.3 million laboratory tests across 194 assays during a two-month observat…
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Temporal inference from laboratory testing results and their triangulation with clinical outcomes as described in the associated unstructured text from the providers notes in the Electronic Health Record (EHR) is integral to advancing precision medicine. Here, we studied 181 COVIDpos and 7,775 COVIDneg patients subjected to 1.3 million laboratory tests across 194 assays during a two-month observation period centered around their SARS-CoV-2 PCR testing dates. We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. However, these measures show opposite longitudinal trends as the infection evolves, with declining fibrinogen and increasing platelet counts to levels that are lower and higher compared to the COVIDneg cohort, respectively. Our EHR augmented curation efforts suggest a minority of patients develop thromboembolic events after the PCR testing date, including rare cases with disseminated intravascular coagulopathy (DIC), with most patients lacking the platelet reductions typically observed in consumptive coagulopathies. These temporal trends present, for the first time, fine-grained resolution of COVID-19 associated coagulopathy (CAC), via a digital framework that synthesizes longitudinal lab measurements with structured medication data and neural network-powered extraction of outcomes from the unstructured EHR. This study demonstrates how a precision medicine platform can help contextualize each patients specific coagulation profile over time, towards the goal of informing better personalization of thromboprophylaxis regimen.
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Submitted 21 May, 2020;
originally announced May 2020.
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Dynamics and multiqubit entanglement in distant resonators
Authors:
Muhammad Waseem,
Muhammad Nehal Khan,
Shahid Qamar
Abstract:
We consider the dynamics of the photon states in distant resonators coupled to a common bus resonator at different positions. The frequencies of distant resonators from a common bus resonator are equally detuned. These frequency detunings are kept larger than the coupling strengths of each resonator to the common bus resonator to satisfy the dispersive interaction regime. In the dispersive regime,…
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We consider the dynamics of the photon states in distant resonators coupled to a common bus resonator at different positions. The frequencies of distant resonators from a common bus resonator are equally detuned. These frequency detunings are kept larger than the coupling strengths of each resonator to the common bus resonator to satisfy the dispersive interaction regime. In the dispersive regime, we show that the time dynamics of the system evolve to an arbitrary W-type state in a single step at various interaction times. Our results show that a one-step generation of arbitrary W-type states can be achieved with high fidelity in a system of superconducting resonators.
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Submitted 24 April, 2020;
originally announced April 2020.
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Initial operation of the recoil mass spectrometer EMMA at the ISAC-II facility of TRIUMF
Authors:
B. Davids,
M. Williams,
N. E. Esker,
M. Alcorta,
D. Connolly,
B. R. Fulton,
K. Hudson,
N. Khan,
O. S. Kirsebom,
J. Lighthall,
P. Machule
Abstract:
The Electromagnetic Mass Analyser (EMMA) is a new vacuum-mode recoil mass spectrometer currently undergoing the final stages of commissioning at the ISAC-II facility of TRIUMF. EMMA employs a symmetric configuration of electrostatic and magnetic deflectors to separate the products of nuclear reactions from the beam, focus them in both energy and angle, and disperse them in a focal plane according…
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The Electromagnetic Mass Analyser (EMMA) is a new vacuum-mode recoil mass spectrometer currently undergoing the final stages of commissioning at the ISAC-II facility of TRIUMF. EMMA employs a symmetric configuration of electrostatic and magnetic deflectors to separate the products of nuclear reactions from the beam, focus them in both energy and angle, and disperse them in a focal plane according to their mass/charge (m/q) ratios. The spectrometer was designed to accommodate the gamma-ray detector array TIGRESS around the target position in order to provide spectroscopic information from electromagnetic transitions. EMMA is intended to be used in the measurement of fusion evaporation, radiative capture, and transfer reactions for the study of nuclear structure and astrophysics. Its complement of focal plane detectors facilitates the identification of recoiling nuclei and subsequent recoil decay spectroscopy. Here we describe the facility and report on commissioning efforts.
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Submitted 16 April, 2019;
originally announced April 2019.
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Topological background discrimination in the PandaX-III neutrinoless double beta decay experiment
Authors:
J Galan,
X Chen,
H Du,
C Fu,
K Giboni,
F Giuliani,
K Han,
B Jiang,
X Ji,
H Lin,
Y Lin,
J Liu,
K Ni,
X Ren,
S Wang,
S Wu,
C Xie,
Y Yang,
D Zhang,
T Zhang,
L Zhao,
S Aune,
Y Bedfer,
E Berthoumieux,
D Calvet
, et al. (42 additional authors not shown)
Abstract:
The PandaX-III experiment plans to search for neutrinoless double beta decay (0$νββ$) of $^{136}$Xe in the China JinPing underground Laboratory (CJPL). The experiment will use a high pressure gaseous Time Projection Chamber (TPC) to register both the energy and the electron track topology of an event. This article is devoted to the software side of the experiment. As software tool we use REST, a f…
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The PandaX-III experiment plans to search for neutrinoless double beta decay (0$νββ$) of $^{136}$Xe in the China JinPing underground Laboratory (CJPL). The experiment will use a high pressure gaseous Time Projection Chamber (TPC) to register both the energy and the electron track topology of an event. This article is devoted to the software side of the experiment. As software tool we use REST, a framework developed for the reconstruction and simulation of TPC-based detector systems. We study the potential for background reduction by introducing appropiate parameters based on the properties of 0$νββ$ events. We exploit for the first time not only the energy density of the electron track-ends, but also the electron scattering angles produced by an electron near the end of its trajectory. To implement this, we have added new algorithms for detector signal and track processing inside REST. Their assessment shows that background can be reduced by about 7 orders of magnitude while keeping 0$νββ$ efficiency above 20% for the PandaX-III baseline readout scheme, a 2-dimensional 3mm-pitch stripped readout. More generally, we use the potential of REST to handle 2D/3D data to assess the impact on signal-to-background significance at different detector granularities, and to validate the PandaX-III baseline choice. Finally, we demonstrate the potential to discriminate surface background events generated at the readout plane in the absence of $t_o$, by making use of event parameters related with the diffusion of electrons.
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Submitted 22 July, 2019; v1 submitted 10 March, 2019;
originally announced March 2019.
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Low energy range dielectronic recombination of Fluorine-like Fe17+ at the CSRm
Authors:
Nadir Khan,
Zhong-Kui Huang,
Wei-Qiang Wen,
Sultan Mahmood,
Li-Jun Dou,
Shu-Xing Wang,
Xin Xu,
Han-Bing Wang,
Chong-Yang Chen,
Xiao-Ya Chuai,
Xiao-Long Zhu,
Dong-Mei Zhao,
Li-Jun Mao,
Jie Li,
Da-yu Yin,
Jian-Cheng Yang,
You-Jin Yuan,
Lin-Fan Zhu,
Xin-Wen Ma
Abstract:
The accuracy of dielectronic recombination (DR) data for astrophysics related ions plays a key role in astrophysical plasma modeling. The measurement of the absolute DR rate coefficient of Fe17+ ions was performed at the main cooler storage ring at Institute of Modern Physics, Lanzhou, China. The experimental electron-ion collision energy range covers first Rydberg series up to n = 24 for the DR r…
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The accuracy of dielectronic recombination (DR) data for astrophysics related ions plays a key role in astrophysical plasma modeling. The measurement of the absolute DR rate coefficient of Fe17+ ions was performed at the main cooler storage ring at Institute of Modern Physics, Lanzhou, China. The experimental electron-ion collision energy range covers first Rydberg series up to n = 24 for the DR resonances associated with the 2P1/2--2P3/2 dn = 0 core excitations. A theoretical calculation was performed by using FAC code and compared with the measured DR rate coefficient. Overall reasonable agreement was found between the experimental results and calculations. Moreover, plasma rate coefficient was deduced from the experimental DR rate coefficient and compared with the available results from the literature. At the low energy range significant discrepancies were found therein and the measured resonances challenged state-of-the-art theory at the low collision energies.
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Submitted 8 April, 2018;
originally announced April 2018.
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PandaX-III: Searching for Neutrinoless Double Beta Decay with High Pressure $^{136}$Xe Gas Time Projection Chambers
Authors:
Xun Chen,
Changbo Fu,
Javier Galan,
Karl Giboni,
Franco Giuliani,
Linghui Gu,
Ke Han,
Xiangdong Ji,
Heng Lin,
Jianglai Liu,
Kaixiang Ni,
Hiroki Kusano,
Xiangxiang Ren,
Shaobo Wang,
Yong Yang,
Dan Zhang,
Tao Zhang,
Li Zhao,
Xiangming Sun,
Shouyang Hu,
Siyu Jian,
Xinglong Li,
Xiaomei Li,
Hao Liang,
Huanqiao Zhang
, et al. (45 additional authors not shown)
Abstract:
Searching for the Neutrinoless Double Beta Decay (NLDBD) is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments. PandaX-III (Particle And Astrophysical Xenon Experiment III) will search for the NLDBD of $^{136}$Xe at the China Jin Ping underground Laboratory (CJPL). In the first phase of the experiment…
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Searching for the Neutrinoless Double Beta Decay (NLDBD) is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments. PandaX-III (Particle And Astrophysical Xenon Experiment III) will search for the NLDBD of $^{136}$Xe at the China Jin Ping underground Laboratory (CJPL). In the first phase of the experiment, a high pressure gas Time Projection Chamber (TPC) will contain 200 kg, 90% $^{136}$Xe enriched gas operated at 10 bar. Fine pitch micro-pattern gas detector (Microbulk Micromegas) will be used at both ends of the TPC for the charge readout with a cathode in the middle. Charge signals can be used to reconstruct tracks of NLDBD events and provide good energy and spatial resolution. The detector will be immersed in a large water tank to ensure $\sim$5 m of water shielding in all directions. The second phase, a ton-scale experiment, will consist of five TPCs in the same water tank, with improved energy resolution and better control over backgrounds.
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Submitted 27 October, 2016; v1 submitted 27 October, 2016;
originally announced October 2016.
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Dufour and Soret effects on MHD flow of Williamson fluid over an infinite rotating disk with anisotropic slip
Authors:
Najeeb Alam Khan,
Faqiha Sultan
Abstract:
This study deals with the investigation of MHD flow of Williamson fluid over an infinite rotating disk with the effects of Soret, Dufour, and anisotropic slip. The anisotropic slip and the Soret and Dufour effects are the primary features of this study, which greatly influence the flow, heat and mass transport properties. In simultaneous appearance of heat and mass transfer in a moving fluid, the…
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This study deals with the investigation of MHD flow of Williamson fluid over an infinite rotating disk with the effects of Soret, Dufour, and anisotropic slip. The anisotropic slip and the Soret and Dufour effects are the primary features of this study, which greatly influence the flow, heat and mass transport properties. In simultaneous appearance of heat and mass transfer in a moving fluid, the mass flux generated by temperature gradients is known as the thermal-diffusion or Soret effect and the energy flux created by a composition gradient is called the diffusion-thermo or Dufour effect, however, difference in slip lengths in streamwise and spanwise directions is named as anisotropic slip. The system of nonlinear partial differential equations (PDEs), which governs the flow, heat and mass transfer characteristics, is transformed into ordinary differential equations (ODEs) with the help of von Kármán similarity transformation. A numerical solution of the complicated ODEs is carried out by a MATLAB routine bvp4c. The obtained results of velocity, temperature, concentration, and some physical quantities are displayed through graphs and tables, and their physical discussion is presented.
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Submitted 25 October, 2016;
originally announced October 2016.
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Study of the effect of semi-infinite crystalline electrodes on transmission of gold atomic wires using DFT
Authors:
Abdul Sattar,
Raja Junaid Amjad,
Sumaira Yasmeen,
Hafsa Javed,
Hamid Latif,
Hasan Mahmood,
Azmat Iqbal,
Arslan Usman,
Majid Niaz Akhtar,
Salman Naeem Khan,
M. R. Dousti
Abstract:
First principle calculations of the conductance of gold wires containing 3-8 atoms each with 2.39 Å bond length were performed using density functional theory. Three different configuration of wire/electrodes were used. For zigzag wire with semi-infinite crystalline electrodes, even-odd oscillation is observed which is consistent with the previously reported results. A lower conductance was observ…
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First principle calculations of the conductance of gold wires containing 3-8 atoms each with 2.39 Å bond length were performed using density functional theory. Three different configuration of wire/electrodes were used. For zigzag wire with semi-infinite crystalline electrodes, even-odd oscillation is observed which is consistent with the previously reported results. A lower conductance was observed for the chain in semi-infinite crystalline electrodes compared to the chains suspended in wire-like electrode. The calculated transmission spectrum for the straight and zig-zag wires suspended between semi-infinite crystalline electrodes showed suppression of transmission channels due to electron scattering occurring at the electrode-wire interface.
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Submitted 29 July, 2015;
originally announced July 2015.
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The Q_weak Experimental Apparatus
Authors:
Qweak Collaboration,
T. Allison,
M. Anderson,
D. Androic,
D. S. Armstrong,
A. Asaturyan,
T. D. Averett,
R. Averill,
J. Balewski,
J. Beaufait,
R. S. Beminiwattha,
J. Benesch,
F. Benmokhtar,
J. Bessuille,
J. Birchall,
E. Bonnell,
J. Bowman,
P. Brindza,
D. B. Brown,
R. D. Carlini,
G. D. Cates,
B. Cavness,
G. Clark,
J. C. Cornejo,
S. Covrig Dusa
, et al. (104 additional authors not shown)
Abstract:
The Jefferson Lab Q_weak experiment determined the weak charge of the proton by measuring the parity-violating elastic scattering asymmetry of longitudinally polarized electrons from an unpolarized liquid hydrogen target at small momentum transfer. A custom apparatus was designed for this experiment to meet the technical challenges presented by the smallest and most precise ${\vec{e}}$p asymmetry…
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The Jefferson Lab Q_weak experiment determined the weak charge of the proton by measuring the parity-violating elastic scattering asymmetry of longitudinally polarized electrons from an unpolarized liquid hydrogen target at small momentum transfer. A custom apparatus was designed for this experiment to meet the technical challenges presented by the smallest and most precise ${\vec{e}}$p asymmetry ever measured. Technical milestones were achieved at Jefferson Lab in target power, beam current, beam helicity reversal rate, polarimetry, detected rates, and control of helicity-correlated beam properties. The experiment employed 180 microA of 89% longitudinally polarized electrons whose helicity was reversed 960 times per second. The electrons were accelerated to 1.16 GeV and directed to a beamline with extensive instrumentation to measure helicity-correlated beam properties that can induce false asymmetries. Moller and Compton polarimetry were used to measure the electron beam polarization to better than 1%. The electron beam was incident on a 34.4 cm liquid hydrogen target. After passing through a triple collimator system, scattered electrons between 5.8 degrees and 11.6 degrees were bent in the toroidal magnetic field of a resistive copper-coil magnet. The electrons inside this acceptance were focused onto eight fused silica Cerenkov detectors arrayed symmetrically around the beam axis. A total scattered electron rate of about 7 GHz was incident on the detector array. The detectors were read out in integrating mode by custom-built low-noise pre-amplifiers and 18-bit sampling ADC modules. The momentum transfer Q^2 = 0.025 GeV^2 was determined using dedicated low-current (~100 pA) measurements with a set of drift chambers before (and a set of drift chambers and trigger scintillation counters after) the toroidal magnet.
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Submitted 6 January, 2015; v1 submitted 24 September, 2014;
originally announced September 2014.
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Three-Way Electrochemical Sensing of Ultra-Low MicroRNA Levels
Authors:
Mahmoud Labib,
Nasrin Khan,
Jenny Cheng,
John Paul Pezacki,
Maxim V. Berezovski
Abstract:
MicroRNAs (miRNAs) are an emerging class of biomarkers that are frequently deregulated in cancer cells and have shown a great promise for cancer classification and prognosis. In this work, we developed a three-way electrochemical sensor for detection and quantitation of ultra-low amounts of miRNAs in a wide dynamic range of measured concentrations. The sensor facilitates three detection modes base…
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MicroRNAs (miRNAs) are an emerging class of biomarkers that are frequently deregulated in cancer cells and have shown a great promise for cancer classification and prognosis. In this work, we developed a three-way electrochemical sensor for detection and quantitation of ultra-low amounts of miRNAs in a wide dynamic range of measured concentrations. The sensor facilitates three detection modes based on hybridization (H-SENS), p19 protein binding (P-SENS) and protein displacement (D-SENS). The combined HPD sensor (HPD-SENS) identifies as low as 5 aM or 90 molecules of miRNA per 30\muL of sample without PCR amplification, and can be operated within the dynamic range from 10 aM to 1 \muM. The HPD senor is made on a commercially-available gold nanoparticles-modified electrode and suitable for analysing multiple miRNAs on a single electrode. This three-way sensor exhibits high selectivity and specificity and was successfully used for sequential analysis of miR-32 and miR-122 on one electrode. Furthermore, the P-SENS was employed for profiling of three endogenous microRNAs (miR-21, miR-32 and miR-122) in human blood serum.
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Submitted 23 August, 2012; v1 submitted 18 August, 2012;
originally announced August 2012.
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The T2K Experiment
Authors:
T2K Collaboration,
K. Abe,
N. Abgrall,
H. Aihara,
Y. Ajima,
J. B. Albert,
D. Allan,
P. -A. Amaudruz,
C. Andreopoulos,
B. Andrieu,
M. D. Anerella,
C. Angelsen,
S. Aoki,
O. Araoka,
J. Argyriades,
A. Ariga,
T. Ariga,
S. Assylbekov,
J. P. A. M. de André,
D. Autiero,
A. Badertscher,
O. Ballester,
M. Barbi,
G. J. Barker,
P. Baron
, et al. (499 additional authors not shown)
Abstract:
The T2K experiment is a long-baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ_{13} by observing ν_e appearance in a ν_μ beam. It also aims to make a precision measurement of the known oscillation parameters, Δm^{2}_{23} and sin^{2} 2θ_{23}, via ν_μ disappearance studies. Other goals of the experiment include various neutrino cross…
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The T2K experiment is a long-baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ_{13} by observing ν_e appearance in a ν_μ beam. It also aims to make a precision measurement of the known oscillation parameters, Δm^{2}_{23} and sin^{2} 2θ_{23}, via ν_μ disappearance studies. Other goals of the experiment include various neutrino cross section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem.
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Submitted 8 June, 2011; v1 submitted 6 June, 2011;
originally announced June 2011.