Skip to main content
Log in

RLeU-Net: Segmentation of blood vessels in retinal fundus images for Diabetic Retinopathy Screening

  • Published:
Multimedia Tools and Applications Aims and scope Submit manuscript

Abstract

Diabetic Retinopathy (DR) is a primitive cause of blindness in diabetic patients. There are chances for DR in certain cases, due to the damage in the retinal vascular area. It may lead to blindness or loss of vision if DR is not detected. At the final stage, there is a threat of loss of vision. During the initial stage of this chronic disease, it has been observed that no symptoms are required to determine the loss of vision. Hence, there is a need for better and early diagnosis of the blood vessels to prevent vision loss in diabetic patients. The primary task of early diagnosis is to carry out a proper segmentation process. But, segmenting vasculture from retinal photographs is a vital laborious effort. Therefore, blood vessel segmentation of fundus images has grown in favor among researchers. There are many existing methods to process bio-medical retinal images, and most of them are computationally intensive and difficult to deploy in real-time. The objective of this work is to develop a novel and efficient deep learning framework to perform the segmentation with the U-Net as a primary module. The U-Net architecture has been modified so that the model would be lightweight and the model is cost efficient in terms of time and space complexity. The proposed method, DRLeU- Net, is evaluated using a publicly available color retinal fundus images dataset. The model was trained using the k-fold cross-validation technique. The proposed method shows a promising results of 0.988 AUC (Area Under the Curve) and 0.94 IOU (Intersection over Union when compared with the existing methods.The robust and efficient deep learning framework has been deployed to do the segmentation process efficiently and it has evauated with the expremental results by comparing with the existing methodologies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+
from $39.99 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
The alternative text for this image may have been generated using AI.
Fig. 2
The alternative text for this image may have been generated using AI.
Fig. 3
The alternative text for this image may have been generated using AI.
Fig. 4
The alternative text for this image may have been generated using AI.
Fig. 5
The alternative text for this image may have been generated using AI.
Fig. 6
The alternative text for this image may have been generated using AI.
Fig. 7
The alternative text for this image may have been generated using AI.
Fig. 8
The alternative text for this image may have been generated using AI.
Fig. 9
The alternative text for this image may have been generated using AI.
Fig. 10
The alternative text for this image may have been generated using AI.
Fig. 11
The alternative text for this image may have been generated using AI.
Fig. 12
The alternative text for this image may have been generated using AI.

Similar content being viewed by others

Data availability

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

References

  1. Cole JB, Florez JC (2020) Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol 16(7):377–390. https://doi.org/10.1038/s41581-020-0278-5

    Article  MATH  Google Scholar 

  2. Narkthewan A, Maneerat N (2019) Retina blood vessel detection for diabetic retinopathy diagnosis. In: Proceedings of the 2019 9th International Conference on Biomedical Engineering and Technology, pp 149–152. https://doi.org/10.1145/3326172.3326203

  3. Diag Mookiah MRK, Acharya UR, Chua CK, Lim CM, Ng EYK, Laude A (2013) Computer-aided diagnosis of diabetic retinopathy: A review. Comput Biol Med 43(12):2136–2155

    Google Scholar 

  4. Mateen M, Wen J, Hassan M, Nasrullah N, Sun S, Hayat S (2020) Automatic detection of diabetic retinopathy: a review on datasets, methods and evaluation metrics. IEEE Access 8:48784–48811

    Google Scholar 

  5. Shenavarmasouleh F, Arabnia HR (2021) Drdr: Automatic masking of exudates and microaneurysms caused by diabetic retinopathy using mask r-cnn and transfer learning. In: Advances in Computer Vision and Computational Biology: Proceedings from IPCV’20, HIMS’20, BIOCOMP’20, and BIOENG’20. Springer International Publishing, Cham, pp 307–318. https://doi.org/10.1007/978-3-030-71051-4_24

  6. Gharaibeh N, Al-Hazaimeh OM, Al-Naami B, Nahar KM (2018) An effective image processing method for detection of diabetic retinopathy diseases from retinal fundus images. Int J Signal Imaging Syst Eng 11(4):206–216

    MATH  Google Scholar 

  7. Wang D, Haytham A, Pottenburgh J, Saeedi O, Tao Y (2020) Hard attention net for automatic retinal vessel segmentation. IEEE J Biomed Health Inform 24(12):3384–3396

    MATH  Google Scholar 

  8. Imran A, Li J, Pei Y, Yang JJ, Wang Q (2019) Comparative analysis of vessel segmentation techniques in retinal images. IEEE Access 7:114862–114887

    MATH  Google Scholar 

  9. Qummar S, Khan FG, Shah S, Khan A, Shamshirband S, Rehman ZU, Khan IA, Jadoon W (2019) A deep learning ensemble approach for diabetic retinopathy detection. Ieee Access 7. https://doi.org/10.1109/ICIINFS.2018.8721315pp.150530-150539.

  10. Jebaseeli TJ, Durai CAD, Peter JD (2019) Segmentation of retinal blood vessels from ophthalmologic diabetic retinopathy images. Comput Electr Eng 73:245–258

    Google Scholar 

  11. Gao J, Chen G, Lin W (2020) An effective retinal blood vessel segmentation by using automatic random walks based on centerline extraction. BioMed Res Int 2020:7352129. https://doi.org/10.1155/2020/7352129

  12. Shukla AK, Pandey RK, Pachori RB (2020) A fractional filter based efficient algorithm for retinal blood vessel segmentation. Biomed Signal Process Control 59:101883

    MATH  Google Scholar 

  13. Syed SR, SaleemDurai MA (2023) A diagnosis model for detection and classification of diabetic retinopathy using deep learning. Netw Model Anal Health Inform Bioinform 12(1):37

    MATH  Google Scholar 

  14. Al-Sharfaa AH, Yousif AY, Al-Saadi EH (2021) Localization of optic disk and exudates detection in retinal fundus images. J Phys Conf Ser 1804(1):012128. https://doi.org/10.1088/1742-6596/1804/1/012128

  15. Jebaseeli TJ, Durai CAD, Peter JD (2019) Extraction of retinal blood vessels on fundus images by kirsch’s template and Fuzzy C-Means. J Med Phys 44(1):21

    Google Scholar 

  16. Mann KS, Kaur S (2017) Segmentation of retinal blood vessels using artificial neural networks for early detection of diabetic retinopathy. In: AIP Conference Proceedings, vol 1836, no. 1. AIP Publishing. https://doi.org/10.1063/1.4981966

  17. Boudegga H, Elloumi Y, Akil M, Bedoui MH, Kachouri R, Abdallah AB (2021) Fast and efficient retinal blood vessel segmentation method based on deep learning network. Comput Med Imaging Graph 90:101902

    Google Scholar 

  18. Maji D, Sekh AA (2020) Automatic grading of retinal blood vessel in deep retinal image diagnosis. J Med Syst 44(10):1–14

    MATH  Google Scholar 

  19. Pan L, Zhang Z, Zheng S, Huang L (2021) MSC-Net: Multitask learning network for retinal vessel segmentation and centerline extraction. Appl Sci 12(1):403

    MATH  Google Scholar 

  20. Ronneberger O, Fischer P, Brox T (2019) U-Net: Convolutional networks for biomedical image segmentation. In: Medical Image Computing and Computer-Assisted Intervention–MICCAI 2015: 18th International Conference, Munich, Germany, 5–9 October 2015, Proceedings, Part III 18. Springer International Publishing, pp 234–241. https://doi.org/10.1007/978-3-319-24574-4_28

  21. Raja C, Balaji L (2019) An automatic detection of blood vessel in retinal images using convolution neural network for diabetic retinopathy detection. Pattern Recognit Image Anal 29(3):533–545

    MATH  Google Scholar 

  22. Ramanathan TT, Hossen M, Sayeed M, Emerson Raja J (2022) A deep learning approach based on stochastic gradient descent and least absolute shrinkage and selection operator for identifying diabetic retinopathy. Indonesian J Electr Eng Comput Sci 25(1):589–600

    MATH  Google Scholar 

  23. Chakraborty S, Jana GC, Kumari D, Swetapadma A (2020) An improved method using supervised learning technique for diabetic retinopathy detection. Int J Inf Technol 12(2):473–477

    Google Scholar 

  24. Nanda P, Duraipandian N (2022) A Novel Optimizer in Deep Neural Network for Diabetic Retinopathy Classification. Comput Syst Sci Eng 43(3):1099–1110

    Google Scholar 

  25. Abdulsahib AA, Mahmoud MA, Aris H, Gunasekaran SS, Mohammed MA (2022) An Automated Image Segmentation and Useful Feature Extraction Algorithm for Retinal Blood Vessels in Fundus Images. Electronics 11(9):1295

    Google Scholar 

  26. Pires R, Avila S, Wainer J, Valle E, Abramoff MD, Rocha A (2019) A data-driven approach to referable diabetic retinopathy detection. Artif Intell Med 96:93–106

    Google Scholar 

  27. Hatamizadeh A, Hosseini H, Patel N, Choi J, Pole CC, Hoeferlin CM, Schwartz SD, Terzopoulos D (2022) RAVIR: A dataset and methodology for the semantic segmentation and quantitative analysis of retinal arteries and veins in infrared reflectance imaging. IEEE J Biomed Health Inform 26(7):3272–3283

    Google Scholar 

  28. Tiwari SS, Dholaria A, Pandey R, Nigam G, Agrawal R, Walambe R, Kotecha K (2021) Deep learning-based framework for retinal vasculature segmentation. In: Intelligent Learning for Computer Vision: Proceedings of Congress on Intelligent Systems 2020. Springer, Singapore, pp 275–290. https://doi.org/10.1007/978-981-33-4582-9_22

Download references

Funding

Not applicable.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to D. Sumathi.

Ethics declarations

Conflicts of intrest

The authors declare that they have no conflict of interest.

Human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

Informed consent

Informed consent does not apply as this was a retrospective review with no identifying patient information.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Code availability

Not applicable.

Competing interests

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Addanki, S., Sumathi, D. RLeU-Net: Segmentation of blood vessels in retinal fundus images for Diabetic Retinopathy Screening. Multimed Tools Appl 84, 6113–6134 (2025). https://doi.org/10.1007/s11042-024-19159-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1007/s11042-024-19159-y

Keywords