Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC)
prevalence in different populations. However, the global landscape of the genetic changes …

Whole-genome sequencing of patient DNA can facilitate diagnosis of a disease, but its
potential for guiding treatment has been under-realized. We interrogated the complete …

Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used
combined transcriptional-metabolomic network analysis to identify metabolic pathways that …

The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise
to form a group of histopathologically heterogenous tumors. To evaluate the molecular …

Background This study aims to identify the causative strain of SARS-CoV-2 in a cluster of
vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain …