User profiles for "author:Gentleman R"

Robert Gentleman

Principal Research Scientist
Verified email at ds.dfci.harvard.edu
Cited by 85135

Orchestrating high-throughput genomic analysis with Bioconductor

W Huber, VJ Carey, R Gentleman, S Anders… - Nature …, 2015 - nature.com
Bioconductor is an open-source, open-development software project for the analysis and
comprehension of high-throughput data in genomics and molecular biology. The project …

[BOOK][B] Bioinformatics and computational biology solutions using R and Bioconductor

R Gentleman, V Carey, W Huber, R Irizarry, S Dudoit - 2005 - books.google.com
Bioconductor is a widely used open source and open development software project for the
analysis and comprehension of data arising from high-throughput experimentation in …

Open source software for the analysis of microarray data

S Dudoit, RC Gentleman, J Quackenbush - Biotechniques, 2003 - Taylor & Francis
DNA microarray assays represent the first widely used application that attempts to build
upon the information provided by genome projects in the study of biological questions. One …

[BOOK][B] R programming for bioinformatics

R Gentleman - 2008 - books.google.com
Focusing on the programming skills needed to use R for the solution of bioinformatics and
computational biology problems, this practical guide covers the fundamentals of the R …

Graphs in molecular biology

W Huber, VJ Carey, L Long, S Falcon, R Gentleman - BMC bioinformatics, 2007 - Springer
Graph theoretical concepts are useful for the description and analysis of interactions and
relationships in biological systems. We give a brief introduction into some of the concepts …

Circulating microRNAs as stable blood-based markers for cancer detection

PS Mitchell, RK Parkin, EM Kroh, BR Fritz… - Proceedings of the …, 2008 - pnas.org
Improved approaches for the detection of common epithelial malignancies are urgently
needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs …

Bioconductor: open software development for computational biology and bioinformatics

RC Gentleman, VJ Carey, DM Bates, B Bolstad… - Genome biology, 2004 - Springer
The Bioconductor project is an initiative for the collaborative creation of extensible software
for computational biology and bioinformatics. The goals of the project include: fostering …

R: a language for data analysis and graphics

R Ihaka, R Gentleman - Journal of computational and graphical …, 1996 - Taylor & Francis
In this article we discuss our experience designing and implementing a statistical computing
language. In developing this new language, we sought to combine what we felt were useful …

rtracklayer: an R package for interfacing with genome browsers

M Lawrence, R Gentleman, V Carey - Bioinformatics, 2009 - pmc.ncbi.nlm.nih.gov
The rtracklayer package supports the integration of existing genome browsers with
experimental data analyses performed in R. The user may (i) transfer annotation tracks to …

A model-based background adjustment for oligonucleotide expression arrays

Z Wu, RA Irizarry, R Gentleman… - Journal of the …, 2004 - Taylor & Francis
High-density oligonucleotide expression arrays are widely used in many areas of
biomedical research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix …