Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …

Validating prognostic or predictive candidate genes in appropriately powered breast cancer
cohorts are of utmost interest. Our aim was to develop an online tool to draw survival plots, …

Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Increased androgen receptor (AR) activity drives therapeutic resistance in advanced prostate
cancer. The most common resistance mechanism is amplification of this locus presumably …

We developed a computational method to characterize aneuploidy in tumor samples based
on coordinated aberrations in expression of genes localized to each chromosomal region. …

Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …

Robustness, the ability to maintain performance in the face of perturbations and uncertainty,
is a long-recognized key property of living systems. Owing to intimate links to cellular …

Purpose Cisplatin is a chemotherapeutic agent not used routinely for breast cancer treatment.
As a DNA cross-linking agent, cisplatin may be effective treatment for hereditary BRCA1-…

What is systems biology if all definitions of biology implicitly or explicitly refer to the study of a
whole object, whether it is a virus, a cell, a bacterium, a protozoan or a metazoan? We treat …